id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,79.19,1,0,,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,80.75,1,0,,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
P13671,C6,Complement component C6,Tier 1,0.795,11,79.62,1,0,,,,1,31,"41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710",1,Immunodeficiency due to a late component of complements deficiency,0.75437296887129
P04156,PRNP,Major prion protein,Tier 1,0.785,70,64.19,1,0,,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,83.5,1,0,,,,1,64,"41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087",1,"hearing loss, autosomal recessive",0.5910507391848663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,90.25,1,0,,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,57.66,1,0,,,,1,1,30161145,1,obesity due to pro-opiomelanocortin deficiency,0.6958797353500403
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
P15144,ANPEP,Aminopeptidase N,Tier 1,0.74,15,93.06,1,0,,,,1,1,33554306,1,cholelithiasis,0.5030146927270738
P0C0L4,C4A,Complement C4-A,Tier 1,0.74,12,83.44,1,0,,,,1,4,"37566081,36619572,34739903,31019918",1,,
Q03405,PLAUR,Urokinase plasminogen activator surface receptor,Tier 1,0.738,13,81.44,1,0,,,,1,2,37533140,1,Abdominal Aortic Aneurysm,0.4819526979346149
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
Q96IY4,CPB2,Carboxypeptidase B2,Tier 1,0.709,10,94.12,0,0,,,,1,4,"37329944,36805075,35861072,30297859",1,type 2 diabetes mellitus,0.19338213943947646
P13987,CD59,CD59 glycoprotein,Tier 1,0.705,17,79.31,1,0,,,,1,1,19915929,1,primary CD59 deficiency,0.7738276843579196
P25311,AZGP1,Zinc-alpha-2-glycoprotein,Tier 1,0.701,9,92.88,0,0,,,,1,1,41325160,1,neoplasm,0.10887540652591159
Q12884,FAP,Prolyl endopeptidase FAP,Tier 1,0.7,4,95.62,1,0,,,,1,7,"40046817,39710916,39026723,37192373,36838669,36494579,35879297",1,psoriasis,0.40173767366839236
P00746,CFD,Complement factor D,Tier 1,0.695,40,91.0,0,0,,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
P00738,HP,Haptoglobin,Tier 1,0.695,15,84.81,1,0,,,,1,76,"41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903",1,Hypercholesterolemia,0.5684135700226365
O95858,TSPAN15,Tetraspanin-15,Tier 1,0.692,3,87.56,1,0,,,,1,1,37047289,1,venous thromboembolism,0.5182425801223098
P00451,F8,Coagulation factor VIII,Tier 1,0.691,25,60.75,1,0,,,,1,13,"40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313",1,hemophilia A,0.9108044347811838
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.685,30,93.0,1,0,,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
P22303,ACHE,Acetylcholinesterase,Tier 1,0.685,78,92.94,0,0,,,,1,135,"41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840",1,Alzheimer disease,0.628678841772617
P03950,ANG,Angiogenin,Tier 1,0.685,56,89.81,0,0,,,,1,99,"41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572",1,amyotrophic lateral sclerosis,0.7865457274017922
P01008,SERPINC1,Antithrombin-III,Tier 1,0.685,27,84.69,0,0,,,,1,11,"32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984",1,hereditary antithrombin deficiency,0.8494671886642873
Q15485,FCN2,Ficolin-2,Tier 1,0.682,13,85.12,0,0,,,,1,2,27490795,1,hypopituitarism,0.2753784074131916
Q07954,LRP1,Prolow-density lipoprotein receptor-related protein 1,Tier 1,0.682,7,79.19,0,0,,,,1,3,"41599761,38996211,25855589",1,developmental dysplasia of the hip,0.6197148309275711
P00918,CA2,Carbonic anhydrase 2,Tier 1,0.68,100,97.38,0,0,,,,1,109,"41955789,41543229,41513346,40854266,40783389,40744710,40660917,40411663,40380946,40321028,39978259,39928524,39716707,39536855,39515698,38946763,38693181,38462338,38409486,37997814,37726778,37148800,37103734,36792529,36410157,36140102,36107718,35490167,35344667,35211356,35194086,35022247,35006986,34619285,34607961,34440571,34399193,34362425,34166652,33832411,33479839,33410656,33230701,33080851,32991252,35516485,32700526,32493583,32331372,32304233",1,Osteopetrosis with renal tubular acidosis,0.7929568656592082
P13501,CCL5,C-C motif chemokine 5,Tier 1,0.68,23,88.44,1,0,,,,1,6,"41371773,39422353,32784904,30578658,29111236,27392463",1,neoplasm,0.12028522937584413
P09958,FURIN,Furin,Tier 1,0.68,48,84.75,0,0,,,,1,4,"36291832,24808863",1,coronary artery disease,0.5783535503692275
P61073,CXCR4,C-X-C chemokine receptor type 4,Tier 1,0.68,33,82.25,1,0,,,,1,17,"40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187",1,WHIM syndrome,0.8009225456235435
P12259,F5,Coagulation factor V,Tier 1,0.68,17,61.91,1,0,,,,1,4,"32696338,15496523,24629635,17878169",1,thrombophilia due to activated protein C resistance,0.7962069693286362
P09382,LGALS1,Galectin-1,Tier 1,0.675,41,96.5,0,0,,,,1,6,"37141264,33006019,31778957",1,glaucoma,0.2854257184852107
P49913,CAMP,Cathelicidin antimicrobial peptide,Tier 1,0.675,20,80.0,1,0,,,,1,30,"41316897,40997974,40501769,39429683,39045230,38471488,37947789,35479481,34957366,33832411,31940088,31099939,26843427,26358810,25659966,25437358,25390494,25048161,25044725,24814025,24325980,23748105,23744070,21673794,18165929,12569622,10913311,10780486,37400771",1,prostate carcinoma,0.11970033909944687
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,Tier 1,0.67,14,81.19,0,0,,,,1,8,"41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856",1,hyper-IgM syndrome type 3,0.8038021669520221
P08581,MET,Hepatocyte growth factor receptor,Tier 1,0.669,100,79.25,0,0,,,,1,149,"42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766",1,papillary renal cell carcinoma,0.84195976263742
P56817,BACE1,Beta-secretase 1,Tier 1,0.668,100,87.5,0,0,,,,1,9,"39241336,36149663,35402070,31513457,30959405,29327496,26473367,23832586,16888322",1,metabolic disease,0.42482013576989197
P08311,CTSG,Cathepsin G,Tier 1,0.667,16,91.38,0,0,,,,1,6,"41316897,40501769,9062133,23598134,19325843",1,tuberculosis,0.37188972877648113
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.665,20,79.56,1,0,,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
Q9Y251,HPSE,Heparanase,Tier 1,0.66,58,94.69,0,0,,,,1,7,"41363219,31252265,30086306,28150826,25295847,23968994,22719856",1,Vitiligo,0.3120033501413742
Q13093,PLA2G7,Platelet-activating factor acetylhydrolase,Tier 1,0.66,33,87.81,0,0,,,,1,1,35187107,1,Platelet-activating factor acetylhydrolase deficiency,0.6405981442654826
P15151,PVR,Poliovirus receptor,Tier 1,0.66,13,84.88,1,0,,,,1,3,"37958909,36598052,16419035",1,Alzheimer disease,0.3596586826147091
P03952,KLKB1,Plasma kallikrein,Tier 1,0.656,22,87.88,1,0,,,,1,6,"40008515,36859809,33674695,28959386,28632925,23692437",1,inherited prekallikrein deficiency,0.7077440022291496
P02461,COL3A1,Collagen alpha-1(III) chain,Tier 1,0.656,11,53.25,0,0,,,,1,1,28453726,1,"Ehlers-Danlos syndrome, vascular type",0.8608667500207768
P15907,ST6GAL1,"Beta-galactoside alpha-2,6-sialyltransferase 1",Tier 1,0.655,4,88.12,0,0,,,,1,1,41889102,1,COVID-19,0.5471103766359176