id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P43007,SLC1A4,Neutral amino acid transporter A,Tier 1.5,0.75,1,80.56,1,0,,,,1,6,"36219068,31989939,27571928,26811678,19046328,16139842",1,spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome,0.8025684205131692
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.748,14,85.25,1,0,,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
O60884,DNAJA2,DnaJ homolog subfamily A member 2,Tier 1.5,0.73,1,83.38,1,0,,,,1,2,"41935727,33879515",1,dengue disease,0.37068859424875583
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.718,4,75.69,1,0,,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.71,0,87.69,0,0,,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.7,3,82.94,1,0,,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P19021,PAM,Peptidyl-glycine alpha-amidating monooxygenase,Tier 1.5,0.695,0,71.69,0,0,,,,1,25,"41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210",1,type 2 diabetes mellitus,0.5754371880839976
P21359,NF1,Neurofibromin,Tier 1.5,0.695,26,87.19,1,0,,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P10586,PTPRF,Receptor-type tyrosine-protein phosphatase F,Tier 1.5,0.69,13,82.0,0,0,,,,1,4,"42101929,39087949,36594741",1,smoking initiation,0.4641111755355386
O00501,CLDN5,Claudin-5,Tier 1.5,0.685,0,83.75,0,0,,,,1,1,18951306,1,genetic disorder,0.40861362787778505
P14384,CPM,Carboxypeptidase M,Tier 1.5,0.68,1,90.31,0,0,,,,1,3,"38876068,38060303,36768220",1,hydronephrosis,0.3163273148871551
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.673,7,82.69,0,0,,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.671,5,81.12,0,0,,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
P16870,CPE,Carboxypeptidase E,Tier 1.5,0.66,0,90.38,0,0,,,,1,16,"39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227",1,BDV syndrome,0.7029731914682913
P98155,VLDLR,Very low-density lipoprotein receptor,Tier 1.5,0.66,27,75.69,1,0,,,,1,1,19188685,1,Dysequilibrium syndrome,0.790164037509625
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.66,4,77.25,0,0,,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
Q13433,SLC39A6,Zinc transporter ZIP6,Tier 1.5,0.66,0,60.44,0,0,,,,1,1,40132409,1,breast cancer,0.11188167100061543
Q9Y625,GPC6,Glypican-6,Tier 1.5,0.655,0,82.0,0,0,,,,1,1,40093223,1,autosomal recessive omodysplasia,0.7503216726357611
P02766,TTR,Transthyretin,Tier 1.5,0.655,0,88.0,0,0,,,,1,11,"39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452",1,"amyloidosis, hereditary systemic 1",0.846421986844374
Q9H0R3,TMEM222,Transmembrane protein 222,Tier 1.5,0.654,0,84.81,0,0,,,,1,3,"41643149,36174865,25998051",1,neurodevelopmental disorder with motor and speech delay and behavioral abnormalities,0.6449281600938256
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.652,14,72.69,1,0,,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
P32942,ICAM3,Intercellular adhesion molecule 3,Tier 1.5,0.648,1,87.12,0,0,,,,1,3,"40650261,34730968,17660953",1,lymphatic system disease,0.28331776251399693
P07237,P4HB,Protein disulfide-isomerase,Tier 1.5,0.644,14,88.5,1,0,,,,1,2,"31625090,28952381",1,Cole-Carpenter syndrome,0.7447295842045853
Q14242,SELPLG,P-selectin glycoprotein ligand 1,Tier 1.5,0.64,1,50.38,0,0,,,,1,1,25979951,1,glaucoma,0.40058604767334977
P01732,CD8A,T-cell surface glycoprotein CD8 alpha chain,Tier 1.5,0.635,8,78.19,0,0,,,,1,2,"38487531,36979667",1,progressive supranuclear palsy,0.2036023725502463
P51884,LUM,Lumican,Tier 1.5,0.625,0,90.38,0,0,,,,1,7,"41744190,36785906,28453726,26230699,24180352,23890607",1,lumbar disc herniation,0.3492311458288365
O75976,CPD,Carboxypeptidase D,Tier 1.5,0.625,3,82.5,1,0,,,,1,1,36457699,1,neurodegenerative disease,0.34777406871587735
P49862,KLK7,Kallikrein-7,Tier 1.5,0.624,12,91.56,0,0,,,,1,1,30114962,1,neurodegenerative disease,0.2420324965785189
P21926,CD9,CD9 antigen,Tier 1.5,0.623,5,88.56,0,0,,,,1,17,"41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386",1,diphtheria,0.5261379875719714
P16671,CD36,Platelet glycoprotein 4,Tier 1.5,0.62,1,93.94,0,0,,,,1,6,"41713143,41140242,39762152,33596054,33291667,31904170",1,platelet-type bleeding disorder 10,0.7360571429413174
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.619,6,79.56,1,0,,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
P10451,SPP1,Osteopontin,Tier 1.5,0.615,3,53.41,0,0,,,,1,62,"41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031",1,osteoporosis,0.5729473764531288
P01876,IGHA1,Immunoglobulin heavy constant alpha 1,Tier 1.5,0.612,14,81.88,1,0,,,,1,2,37325361,1,IGA glomerulonephritis,0.12053726815801102
O43866,CD5L,CD5 antigen-like,Tier 1.5,0.61,4,85.88,1,0,,,,1,3,"40215752,37100807",1,functional neutrophil defect,0.3529395470693119
O75487,GPC4,Glypican-4,Tier 1.5,0.61,0,83.19,0,0,,,,1,1,40766128,1,Keipert syndrome,0.737596102373947
P23368,ME2,"NAD-dependent malic enzyme, mitochondrial",Tier 1.5,0.61,18,94.38,1,0,,,,1,2,"39602246,29779113",1,diabetes mellitus,0.277416610655893
Q12891,HYAL2,Hyaluronidase-2,Tier 1.5,0.61,0,91.0,0,0,,,,1,1,37353120,1,Muggenthaler-Chowdhury-Chioza syndrome,0.6952425210951342
P15529,CD46,Membrane cofactor protein,Tier 1.5,0.608,7,82.12,1,0,,,,1,9,"35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032",1,atypical hemolytic-uremic syndrome with MCP/CD46 anomaly,0.7798469882597787
P55157,MTTP,Microsomal triglyceride transfer protein large subunit,Tier 1.5,0.608,2,86.56,1,0,,,,1,1,23770039,1,abetalipoproteinemia,0.8281089516017405
O75508,CLDN11,Claudin-11,Tier 1.5,0.608,0,85.75,0,0,,,,1,1,35207732,1,"leukodystrophy, hypomyelinating, 22",0.6787731842933689
P10646,TFPI,Tissue factor pathway inhibitor,Tier 1.5,0.605,9,73.62,1,0,,,,1,28,"32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161",1,hemophilia A,0.5591056672248635
P10909,CLU,Clusterin,Tier 1.5,0.605,2,77.31,0,0,,,,1,5,"42041411,37179603,36980195,35383192,26061649",1,Alzheimer disease,0.5545645077431476