id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
O60315,ZEB2,Zinc finger E-box-binding homeobox 2,Tier 1.5,0.789,1,A2_pm_peripheral,1,48.16,0,0,,,1,3,"27719642,24146916,18698484",1,Mowat-Wilson syndrome,0.8313744323041312
P11274,BCR,Breakpoint cluster region protein,Tier 1.5,0.785,1,A2_pm_peripheral,5,64.81,0,0,,,1,20,"41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794",1,chronic myelogenous leukemia,0.8183048540102864
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.776,1,A2_pm_peripheral,6,79.56,1,0,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
P55263,ADK,Adenosine kinase,Tier 1.5,0.769,1,A2_pm_peripheral,4,93.31,0,0,,,1,2,26051465,1,adenosine kinase deficiency,0.7617058236708037
P35241,RDX,Radixin,Tier 1.5,0.749,1,A2_pm_peripheral,2,86.56,0,0,,,1,2,"33253235,30700648",1,"hearing loss, autosomal recessive",0.6973070672344621
P32121,ARRB2,Beta-arrestin-2,Tier 1.5,0.719,1,A2_pm_peripheral,1,83.81,1,0,,,1,4,"24736311,40652239,29054528",1,cancer,0.5962458729823639
P09769,FGR,Tyrosine-protein kinase Fgr,Tier 1.5,0.716,1,A2_pm_peripheral,3,82.19,0,0,,,1,1,39564692,1,chronic myelogenous leukemia,0.5869168331059803
P42680,TEC,Tyrosine-protein kinase Tec,Tier 1.5,0.705,1,A2_pm_peripheral,1,85.0,0,0,,,1,13,"39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764",1,alopecia areata,0.5491699656070116
P17252,PRKCA,Protein kinase C alpha type,Tier 1.5,0.704,1,A2_pm_peripheral,6,86.38,0,0,,,1,1,41505229,1,acute myeloid leukemia,0.547429504944985
Q96PY5,FMNL2,Formin-like protein 2,Tier 1.5,0.695,1,A2_pm_peripheral,1,76.44,0,0,,,1,1,41149482,1,open-angle glaucoma,0.5157968177633478
P09543,CNP,"2',3'-cyclic-nucleotide 3'-phosphodiesterase",Tier 1.5,0.689,1,A2_pm_peripheral,1,87.25,0,0,,,1,9,"40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295",1,"myopia 2, autosomal dominant",0.49606855995054094
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.689,1,A2_pm_peripheral,8,89.75,1,0,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
P21980,TGM2,Protein-glutamine gamma-glutamyltransferase 2,Tier 1.5,0.688,1,A2_pm_peripheral,17,92.88,1,0,,,1,1,35980938,1,neurodegenerative disease,0.49455272812698803
P63098,PPP3R1,Calcineurin subunit B type 1,Tier 1.5,0.673,1,A2_pm_peripheral,21,91.12,1,0,,,1,2,39263947,1,Abnormality of the skeletal system,0.44389060142742937
P56470,LGALS4,Galectin-4,Tier 1.5,0.63,1,A2_pm_peripheral,13,89.62,0,0,,,1,2,38811951,1,neurodegenerative disease,0.2996682866922638
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
P49862,KLK7,Kallikrein-7,Tier 1.5,0.613,1,A2_pm_peripheral,12,91.56,0,0,,,1,1,30114962,1,neurodegenerative disease,0.2420324965785189
O14640,DVL1,Segment polarity protein dishevelled homolog DVL-1,Tier 1.5,0.611,1,A2_pm_peripheral,3,59.84,0,0,,,1,1,37231925,0,autosomal dominant Robinow syndrome,0.7359277384599506
Q2Q1W2,TRIM71,E3 ubiquitin-protein ligase TRIM71,Tier 1.5,0.578,1,A2_pm_peripheral,2,79.12,0,0,,,1,2,31732746,0,"hydrocephalus, congenital communicating, 1",0.6276048232841862
P34949,MPI,Mannose-6-phosphate isomerase,Tier 1.5,0.549,0,A2_pm_peripheral,0,96.44,0,0,,,1,2,"40164941,23933583",1,MPI-congenital disorder of glycosylation,0.8451488759060135
Q8NF50,DOCK8,Dedicator of cytokinesis protein 8,Tier 1.5,0.537,0,A2_pm_peripheral,0,74.56,0,0,,,1,2,"31754797,31029337",1,combined immunodeficiency due to DOCK8 deficiency,0.8059148942715584
P20794,MAK,Serine/threonine-protein kinase MAK,Tier 1.5,0.527,0,A2_pm_peripheral,0,62.12,0,0,,,1,3,"38953438,24204723,18558676",1,retinitis pigmentosa,0.7734151865428234
Q9Y2K6,USP20,Ubiquitin carboxyl-terminal hydrolase 20,Tier 1.5,0.509,1,A2_pm_peripheral,1,72.31,0,0,,,1,1,30863411,0,connective tissue neoplasm,0.3981371748391643
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
P32298,GRK4,G protein-coupled receptor kinase 4,Tier 1.5,0.49,1,A2_pm_peripheral,1,88.69,0,0,,,1,2,31555351,0,Nausea and vomiting,0.33267400228074584
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556
Q5VT25,CDC42BPA,Serine/threonine-protein kinase MRCK alpha,Tier 1.5,0.45,0,A2_pm_peripheral,0,75.06,0,0,,,1,2,20564698,1,neurodegenerative disease,0.5178529990008665
P19957,PI3,Elafin,Tier 1.5,0.446,1,A2_pm_peripheral,3,72.25,0,0,,,1,3,"37351609,36517803,30087279",0,Abruptio Placentae,0.18626794135552627
Q9NRA1,PDGFC,Platelet-derived growth factor C,Tier 1.5,0.423,0,A2_pm_peripheral,0,75.56,0,0,,,1,2,11912250,1,Abnormality of the skeletal system,0.42503153735116955
Q9H4F8,SMOC1,SPARC-related modular calcium-binding protein 1,Tier 1.5,0.388,0,A2_pm_peripheral,0,73.31,0,0,,,1,1,36333824,0,microphthalmia with limb anomalies,0.8103774498041117
Q9UHK6,AMACR,Alpha-methylacyl-CoA racemase,Tier 1.5,0.374,0,A2_pm_peripheral,0,95.81,0,0,,,1,10,"40271962,35780537,35539643,26547498,24994506",0,Alpha-methylacyl-CoA racemase deficiency,0.762086344446303
O75781,PALM,Paralemmin-1,Tier 1.5,0.356,0,A2_pm_peripheral,0,69.0,0,0,,,1,12,"41849311,40440017,39602515,37268031,37162861,36358301,32726320,28237901,26296781,25811093,17467026,16849623",1,Anxiety,0.20355734593659502
O14543,SOCS3,Suppressor of cytokine signaling 3,Tier 1.5,0.287,0,A2_pm_peripheral,0,71.88,0,0,,,1,2,39571081,0,neurodegenerative disease,0.47223972419523075
Q9P2M7,CGN,Cingulin,Tier 1.5,0.251,0,A2_pm_peripheral,0,69.56,0,0,,,1,3,"35297595,33476120,21342520",0,Abnormality of the skeletal system,0.3547927821140923
Q8WW22,DNAJA4,DnaJ homolog subfamily A member 4,Tier 1.5,0.241,0,A2_pm_peripheral,0,84.44,0,0,,,1,2,"41935727,33879515",0,coronary atherosclerosis,0.3210951574534216
Q9Y5Z7,HCFC2,Host cell factor 2,Tier 1.5,0.235,0,A2_pm_peripheral,0,72.88,0,0,,,1,24,"41651417,41187655,40586934,40410820,40371468,38829419,38471488,36836536,36517803,36480517,34132569,32981365,32884147,32157871,32101978,31985806,31077760,25534780,23770039,20967861,20445260,19195013,15629041,12177446",0,neurodegenerative disease,0.29928415571034084
Q6XZB0,LIPI,Lipase member I,Tier 1.5,0.215,0,A2_pm_peripheral,0,89.44,0,0,,,1,2,"32981012,27715478",0,metabolic disease,0.23399905961107478
Q8N143,BCL6B,B-cell CLL/lymphoma 6 member B protein,Tier 1.5,0.199,0,A2_pm_peripheral,0,54.31,0,0,,,1,1,41169059,0,tympanic membrane perforation,0.18130132303178323
Q16206,ENOX2,Ecto-NOX disulfide-thiol exchanger 2,Tier 1.5,0.167,0,A2_pm_peripheral,0,77.06,0,0,,,1,2,37504074,0,chronic myelogenous leukemia,0.0726224414455439
O77932,DXO,Decapping and exoribonuclease protein,Tier 1.5,0.161,0,A2_pm_peripheral,0,92.69,0,0,,,1,2,27432610,0,breast cancer,0.05174117965585824