id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.847,1,A_assoc,3,82.94,1,0,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.836,1,A_assoc,9,50.62,1,0,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P35625,TIMP3,Metalloproteinase inhibitor 3,Tier 1.5,0.831,1,A_assoc,1,87.0,0,0,,,1,3,"42105605,36768220",1,Sorsby fundus dystrophy,0.7684253675298044
P02748,C9,Complement component C9,Tier 1.5,0.829,1,A_assoc,9,78.75,1,0,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
P36955,SERPINF1,Pigment epithelium-derived factor,Tier 1.5,0.811,1,A_assoc,3,90.12,0,0,,,1,17,"41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805",1,osteogenesis imperfecta,0.701995723393119
O00187,MASP2,Mannan-binding lectin serine protease 2,Tier 1.5,0.81,1,A_assoc,10,89.44,0,0,,,1,1,40371468,1,immunodeficiency due to MASP-2 deficiency,0.6996393077218865
Q16270,IGFBP7,Insulin-like growth factor-binding protein 7,Tier 1.5,0.785,1,A_assoc,1,84.44,0,0,,,1,4,"41192243,27679852,41280530",1,familial retinal arterial macroaneurysm,0.6182241349863704
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.775,1,A_assoc,4,75.69,1,0,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
P10451,SPP1,Osteopontin,Tier 1.5,0.772,1,A_assoc,3,53.41,0,0,,,1,62,"41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031",1,osteoporosis,0.5729473764531288
P10646,TFPI,Tissue factor pathway inhibitor,Tier 1.5,0.768,1,A_assoc,9,73.62,1,0,,,1,28,"32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161",1,hemophilia A,0.5591056672248635
P10909,CLU,Clusterin,Tier 1.5,0.766,1,A_assoc,2,77.31,0,0,,,1,5,"42041411,37179603,36980195,35383192,26061649",1,Alzheimer disease,0.5545645077431476
P13497,BMP1,Bone morphogenetic protein 1,Tier 1.5,0.766,1,A_assoc,8,81.44,0,0,,,1,1,39939919,1,osteogenesis imperfecta,0.5547577676549571
P02771,AFP,Alpha-fetoprotein,Tier 1.5,0.765,1,A_assoc,5,88.94,1,0,,,1,195,"41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361",1,Congenital deficiency in alpha-fetoprotein,0.5500580170557311
P55145,MANF,Mesencephalic astrocyte-derived neurotrophic factor,Tier 1.5,0.761,1,A_assoc,3,81.69,0,0,,,1,1,12698297,1,"diabetes, deafness, developmental delay, and short stature syndrome",0.5377386885662411
P24593,IGFBP5,Insulin-like growth factor-binding protein 5,Tier 1.5,0.711,1,A_assoc,3,76.06,1,0,,,1,4,"39317671,31930684",1,hypothyroidism,0.3702458751451027
Q00604,NDP,Norrin,Tier 1.5,0.707,1,A_assoc,11,83.56,1,0,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
O43866,CD5L,CD5 antigen-like,Tier 1.5,0.706,1,A_assoc,4,85.88,1,0,,,1,3,"40215752,37100807",1,functional neutrophil defect,0.3529395470693119
P10145,CXCL8,Interleukin-8,Tier 1.5,0.706,1,A_assoc,21,88.06,1,0,,,1,15,"39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312",1,coronary artery disease,0.35357870191996843
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.706,1,A_assoc,4,77.25,0,0,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
P12273,PIP,Prolactin-inducible protein,Tier 1.5,0.701,1,A_assoc,1,89.69,0,0,,,1,7,"41440247,36179084,35726753,35336001,28107930,26297462,21559755",1,neurodegenerative disease,0.3382059336442212
P80162,CXCL6,C-X-C motif chemokine 6,Tier 1.5,0.699,1,A_assoc,2,81.0,1,0,,,1,3,"40008515,36649818,32628701",1,neurodegenerative disease,0.3309117033683961
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.693,1,A_assoc,5,81.12,0,0,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
Q13253,NOG,Noggin,Tier 1.5,0.685,1,A_assoc,2,86.06,0,0,,,1,2,38397086,0,proximal symphalangism 1A,0.7844136456463046
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.685,1,A_assoc,3,68.62,1,0,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.684,1,A_assoc,8,73.25,0,0,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.682,1,A_assoc,5,87.06,0,0,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
O15520,FGF10,Fibroblast growth factor 10,Tier 1.5,0.67,1,A_assoc,2,80.0,0,0,,,1,1,35415885,0,Lacrimoauriculodentodigital syndrome,0.7344198619465704
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,Tier 1.5,0.666,1,A_assoc,1,86.5,0,0,,,1,1,15562003,0,juvenile Paget disease,0.7184894548525037
P19835,CEL,Bile salt-activated lipase,Tier 1.5,0.658,1,A_assoc,7,82.56,0,0,,,1,2,"39653009,34940276",0,MODY,0.6940743944678538
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.652,1,A_assoc,1,79.62,0,0,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
O75594,PGLYRP1,Peptidoglycan recognition protein 1,Tier 1.5,0.649,1,A_assoc,1,91.0,0,0,,,1,2,"35821507,33534888",1,dementia,0.16478389504231422
P02776,PF4,Platelet factor 4,Tier 1.5,0.635,1,A_assoc,10,75.06,0,0,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
O76093,FGF18,Fibroblast growth factor 18,Tier 1.5,0.631,1,A_assoc,1,87.56,0,0,,,1,1,35415885,0,cancer,0.6028027301556572
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.631,1,A_assoc,1,81.5,0,0,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
O95445,APOM,Apolipoprotein M,Tier 1.5,0.631,1,A_assoc,3,89.44,0,0,,,1,10,"38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696",1,type 2 diabetes mellitus,0.10169659060091507
Q9GZX6,IL22,Interleukin-22,Tier 1.5,0.619,1,A_assoc,6,88.12,0,0,,,1,7,"34208021,33869115,28942363,26792955,37041650",0,atopic eczema,0.5627493881195745
Q15726,KISS1,Metastasis-suppressor KiSS-1,Tier 1.5,0.618,1,A_assoc,2,59.41,1,0,,,1,1,35026192,0,hypogonadotropic hypogonadism,0.5608645918536114
P22466,GAL,Galanin peptides,Tier 1.5,0.613,1,A_assoc,10,66.56,1,0,,,1,27,"40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673",0,temporal lobe epilepsy,0.5442263564708273
P02766,TTR,Transthyretin,Tier 1.5,0.609,0,A_assoc,0,88.0,0,0,,,1,11,"39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452",1,"amyloidosis, hereditary systemic 1",0.846421986844374
P56703,WNT3,Proto-oncogene Wnt-3,Tier 1.5,0.608,1,A_assoc,1,88.25,0,0,,,1,2,"40168709,18673242",0,neurodegenerative disease,0.5272184953415704
P43251,BTD,Biotinidase,Tier 1.5,0.607,0,A_assoc,0,86.19,0,0,,,1,1,27628341,1,biotinidase deficiency,0.8394965674633185
P02654,APOC1,Apolipoprotein C-I,Tier 1.5,0.6,1,A_assoc,8,70.69,0,0,,,1,4,"41316897,40501769,35415203,15132764",1,,
P24855,DNASE1,Deoxyribonuclease-1,Tier 1.5,0.591,1,A_assoc,1,94.25,0,0,,,1,1,36838023,0,systemic lupus erythematosus,0.4692224712894944
P41271,NBL1,Neuroblastoma suppressor of tumorigenicity 1,Tier 1.5,0.585,1,A_assoc,2,75.75,0,0,,,1,2,"35026285,29281176",0,nontoxic goiter,0.44859094265791405
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.583,1,A_assoc,4,76.19,0,0,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P01031,C5,Complement C5,Tier 1.5,0.58,0,A_assoc,0,81.56,0,0,,,1,58,"41407269,41159487,40915733,40683108,40479828,40243681,39831626,39318191,39263947,39073397,38694318,38179195,37566081,35442665,35056853,34637287,33398182,33039563,32882310,32784904,32463617,31862877,31460550,31301466,31184617,30810582,30633241,29850750,29846697,29341876,29294056,28918528,28104543,26947566,26838458,26221631,26057195,23887360,23662585,23595830,19843610,19469583,17263432,16518777,15745996,14980623,14552769,12903182,12490703,10408383",1,Immunodeficiency due to a late component of complements deficiency,0.7500698741801265
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.573,1,A_assoc,4,75.62,1,0,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.572,0,A_assoc,0,87.69,0,0,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.566,1,A_assoc,4,79.81,0,0,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
P35443,THBS4,Thrombospondin-4,Tier 1.5,0.559,0,A_assoc,0,84.56,0,0,,,1,3,"28252048,38045440,32527800",1,Abnormality of the skeletal system,0.6783866364728552