id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P04839,CYBB,NADPH oxidase 2,Tier 1,0.959,1,A_surface,6,90.25,1,0,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P21802,FGFR2,Fibroblast growth factor receptor 2,Tier 1,0.959,1,A_surface,62,73.94,0,0,,,1,5,"41786503,39759879,31357131,24242861,19212647",1,Crouzon syndrome,0.8637438969881663
P78504,JAG1,Protein jagged-1,Tier 1,0.958,1,A_surface,7,73.12,0,0,,,1,4,"37338014,37052638,23341879,18673242",1,Alagille syndrome due to a JAG1 point mutation,0.8586542923232751
P11166,SLC2A1,"Solute carrier family 2, facilitated glucose transporter member 1",Tier 1,0.956,1,A_surface,5,90.25,0,0,,,1,2,"39627234,33184583",1,encephalopathy due to GLUT1 deficiency,0.8521823225896756
P29965,CD40LG,CD40 ligand,Tier 1,0.954,1,A_surface,8,82.62,1,0,,,1,6,"37331977,36203210,26504624",1,hyper-IgM syndrome type 1,0.8451678829647167
P11362,FGFR1,Fibroblast growth factor receptor 1,Tier 1,0.954,1,A_surface,82,73.88,0,0,,,1,13,"41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904",1,hypogonadotropic hypogonadism 2 with or without anosmia,0.8472925100660907
P08581,MET,Hepatocyte growth factor receptor,Tier 1,0.953,1,A_surface,100,79.25,0,0,,,1,149,"42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766",1,papillary renal cell carcinoma,0.84195976263742
P06213,INSR,Insulin receptor,Tier 1,0.953,1,A_surface,87,77.62,0,0,,,1,14,"33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487",1,Leprechaunism,0.8448849372402896
Q8WZ42,TTN,Titin,Tier 1,0.953,1,A_surface,64,,0,0,,,1,1,29952259,1,dilated cardiomyopathy,0.8419847660466327
P37173,TGFBR2,TGF-beta receptor type-2,Tier 1,0.952,1,A_surface,22,81.0,1,0,,,1,8,"32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769",1,Loeys-Dietz syndrome,0.8390072008866913
P19438,TNFRSF1A,Tumor necrosis factor receptor superfamily member 1A,Tier 1,0.951,1,A_surface,13,71.38,1,0,,,1,1,35197258,1,TNF receptor 1-associated periodic fever syndrome,0.8352778213184682
P06744,GPI,Glucose-6-phosphate isomerase,Tier 1,0.949,1,A_surface,13,97.94,1,0,,,1,19,"41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815",1,hemolytic anemia due to glucophosphate isomerase deficiency,0.8306909118751346
P36897,TGFBR1,TGF-beta receptor type-1,Tier 1,0.948,1,A_surface,44,84.19,1,0,,,1,1,41089000,1,Loeys-Dietz syndrome 1,0.8275292516338373
P36894,BMPR1A,Bone morphogenetic protein receptor type-1A,Tier 1,0.948,1,A_surface,11,82.62,0,0,,,1,1,30537181,1,juvenile polyposis syndrome,0.8278395086688584
P22607,FGFR3,Fibroblast growth factor receptor 3,Tier 1,0.948,1,A_surface,13,74.19,1,0,,,1,6,"38569854,37704353,34864168,33952673,31357131",1,achondroplasia,0.8270702096931246
P04156,PRNP,Major prion protein,Tier 1,0.947,1,A_surface,70,64.19,1,0,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
P08069,IGF1R,Insulin-like growth factor 1 receptor,Tier 1,0.945,1,A_surface,46,78.0,1,0,,,1,10,"40997970,39263947,33410883,30041514,23373648,16019422,15231297",1,growth delay due to insulin-like growth factor I resistance,0.8166352227841136
Q13563,PKD2,Polycystin-2,Tier 1,0.943,1,A_surface,31,70.12,1,0,,,1,3,"41315228,36126144",1,polycystic kidney disease 2,0.810960823768978
O75844,ZMPSTE24,CAAX prenyl protease 1 homolog,Tier 1,0.942,1,A_surface,4,89.44,0,0,,,1,1,37565451,1,mandibuloacral dysplasia with type B lipodystrophy,0.8071967390737101
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,Tier 1,0.941,1,A_surface,14,81.19,0,0,,,1,8,"41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856",1,hyper-IgM syndrome type 3,0.8038021669520221
P58335,ANTXR2,Anthrax toxin receptor 2,Tier 1,0.941,1,A_surface,14,71.81,1,0,,,1,4,"41503480,41083485,41020397,40313273",1,hyaline fibromatosis syndrome,0.8028849863986661
P61073,CXCR4,C-X-C chemokine receptor type 4,Tier 1,0.94,1,A_surface,33,82.25,1,0,,,1,17,"40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187",1,WHIM syndrome,0.8009225456235435
Q16832,DDR2,Discoidin domain-containing receptor 2,Tier 1,0.936,1,A_surface,5,75.81,0,0,,,1,1,26067556,1,spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome,0.7854778386444168
P13987,CD59,CD59 glycoprotein,Tier 1,0.932,1,A_surface,17,79.31,1,0,,,1,1,19915929,1,primary CD59 deficiency,0.7738276843579196
Q13554,CAMK2B,Calcium/calmodulin-dependent protein kinase type II subunit beta,Tier 1,0.932,1,A_surface,4,70.56,0,0,,,1,2,"29784938,26594036",1,"intellectual disability, autosomal dominant 54",0.7745713380655789
P29317,EPHA2,Ephrin type-A receptor 2,Tier 1,0.931,1,A_surface,100,82.25,0,0,,,1,16,"40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789",1,Total congenital cataract,0.7690993612962792
P12821,ACE,Angiotensin-converting enzyme,Tier 1,0.93,1,A_surface,97,90.94,0,0,,,1,108,"41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776",1,diabetic nephropathy,0.7656590329495216
P02511,CRYAB,Alpha-crystallin B chain,Tier 1,0.925,1,A_surface,21,75.75,1,0,,,1,2,"28720498,23530262",1,myofibrillar myopathy 2,0.7505030087389963
Q14432,PDE3A,"cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A",Tier 1,0.924,1,A_surface,9,60.25,1,0,,,1,1,34456709,1,Brachydactyly - arterial hypertension,0.7468849549430213
P01019,AGT,Angiotensinogen,Tier 1,0.921,1,A_surface,22,86.44,0,0,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P01730,CD4,T-cell surface glycoprotein CD4,Tier 1,0.921,1,A_surface,85,85.25,0,0,,,1,96,"41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998",1,HIV infection,0.7364522622142639
P07204,THBD,Thrombomodulin,Tier 1,0.92,1,A_surface,13,78.62,1,0,,,1,5,"41988704,34708097,28549218,21526769,7622501",1,thrombomodulin-related bleeding disorder,0.7323266135403641
Q9H244,P2RY12,P2Y purinoceptor 12,Tier 1,0.919,1,A_surface,5,84.44,1,0,,,1,2,"32679592,19509485",1,platelet-type bleeding disorder 8,0.7304079345653686
P21589,NT5E,5'-nucleotidase,Tier 1,0.916,1,A_surface,50,91.88,0,0,,,1,3,"38689291,30472954,25720604",1,hereditary arterial and articular multiple calcification syndrome,0.7199342086353593
P08575,PTPRC,Receptor-type tyrosine-protein phosphatase C,Tier 1,0.916,1,A_surface,6,76.06,1,0,,,1,1,25251012,1,immunodeficiency 104,0.7200430416648742
Q9UNQ0,ABCG2,Broad substrate specificity ATP-binding cassette transporter ABCG2,Tier 1,0.915,1,A_surface,29,85.25,1,0,,,1,8,"40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544",1,gout,0.7158028003520317
P22455,FGFR4,Fibroblast growth factor receptor 4,Tier 1,0.915,1,A_surface,52,73.62,0,0,,,1,2,"39759879,30297602",1,cancer,0.7150377661800104
P13612,ITGA4,Integrin alpha-4,Tier 1,0.914,1,A_surface,7,84.44,1,0,,,1,3,"30065768,28670693,26504766",1,Crohn's disease,0.7134551179424343
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.911,1,A_surface,27,79.19,1,0,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
P40189,IL6ST,Interleukin-6 receptor subunit beta,Tier 1,0.911,1,A_surface,20,74.62,1,0,,,1,2,"39571081,22258147",1,Autosomal recessive hyper-IgE syndrome,0.7027634038262931
P09601,HMOX1,Heme oxygenase 1,Tier 1,0.905,1,A_surface,26,82.88,0,0,,,1,6,"37533140,40526855,40509588,39812275,37457170",1,heme oxygenase 1 deficiency,0.6838783130237968
P35968,KDR,Vascular endothelial growth factor receptor 2,Tier 1,0.904,1,A_surface,54,71.12,0,0,,,1,22,"29608400,27490795,26125598,10548435,9685413,41572478,41187655,39225423,33191671,32199927,30626772,21970900,21907194,20237249,19135441,18499900,17347807,16842232,16787141",1,neoplasm,0.681272749535704
Q9NZQ7,CD274,Programmed cell death 1 ligand 1,Tier 1,0.903,1,A_surface,74,88.25,0,0,,,1,67,"41855853,41830812,41781380,41770936,41629133,41479885,41205458,41195987,41173800,40972397,40811947,40789156,40758411,40682599,40581004,40516668,40209314,40188671,40119836,40016918,40012368,39929085,39916963,39824759,39805944,39532409,39454136,39440615,39417693,39352679,39344385,39332044,39222892,39003918,38940673,38859589,38763821,38636085,38621341,38446717,37944524,37923412,37531891,37364303,36484532,35972912,35624582,35268583,34523014,34156677",1,non-small cell lung carcinoma,0.6769230776549127
Q15303,ERBB4,Receptor tyrosine-protein kinase erbB-4,Tier 1,0.903,1,A_surface,14,73.12,1,0,,,1,3,"32592467,30697465,23990977",1,non-small cell lung carcinoma,0.6754899662390331
P17181,IFNAR1,Interferon alpha/beta receptor 1,Tier 1,0.901,1,A_surface,5,78.0,0,0,,,1,1,27068091,1,"immunodeficiency 106, susceptibility to viral infections",0.6703994774055272
Q07075,ENPEP,Glutamyl aminopeptidase,Tier 1,0.9,1,A_surface,7,93.5,0,0,,,1,2,38467937,1,hypertension,0.6677707312760746
O15455,TLR3,Toll-like receptor 3,Tier 1,0.899,1,A_surface,20,90.62,1,0,,,1,7,"26018150,25528762,17150912,17150911",1,Herpetic encephalitis,0.6617401048830444
P27487,DPP4,Dipeptidyl peptidase 4,Tier 1,0.893,1,A_surface,100,96.25,0,0,,,1,4,"30056058,26605646",1,type 2 diabetes mellitus,0.6432827162361505
P07550,ADRB2,Beta-2 adrenergic receptor,Tier 1,0.89,1,A_surface,100,79.12,1,0,,,1,2,"41637639,32376022",1,asthma,0.634300392456126
P27338,MAOB,Amine oxidase [flavin-containing] B,Tier 1,0.889,1,A_surface,56,95.62,0,0,,,1,1,26841904,1,Parkinson disease,0.6302940908016386