id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21359,NF1,Neurofibromin,Tier 1.5,0.965,1,A_surface,26,87.19,1,0,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P00813,ADA,Adenosine deaminase,Tier 1.5,0.957,1,A_surface,2,96.56,0,0,,,1,72,"42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330",1,Severe combined immunodeficiency due to adenosine deaminase deficiency,0.8556816060494579
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.949,1,A_surface,11,75.94,0,0,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.945,1,A_surface,14,72.69,1,0,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
P04626,ERBB2,Receptor tyrosine-protein kinase erbB-2,Tier 1.5,0.934,1,A_surface,63,74.0,0,0,,,1,119,"41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408",1,non-small cell lung carcinoma,0.7789523142843545
P15529,CD46,Membrane cofactor protein,Tier 1.5,0.934,1,A_surface,7,82.12,1,0,,,1,9,"35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032",1,atypical hemolytic-uremic syndrome with MCP/CD46 anomaly,0.7798469882597787
P24394,IL4R,Interleukin-4 receptor subunit alpha,Tier 1.5,0.923,1,A_surface,10,54.75,0,0,,,1,3,"32751068,27819142,22282665",1,asthma,0.742115080702623
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.921,1,A_surface,7,77.88,1,0,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P16671,CD36,Platelet glycoprotein 4,Tier 1.5,0.921,1,A_surface,1,93.94,0,0,,,1,6,"41713143,41140242,39762152,33596054,33291667,31904170",1,platelet-type bleeding disorder 10,0.7360571429413174
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.919,1,A_surface,7,82.69,0,0,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P08637,FCGR3A,Low affinity immunoglobulin gamma Fc region receptor III-A,Tier 1.5,0.912,1,A_surface,15,85.69,0,0,,,1,2,"41249026,21531729",1,autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity,0.7061437347032623
P02786,TFRC,Transferrin receptor protein 1,Tier 1.5,0.887,1,A_surface,22,86.69,1,0,,,1,3,"39831311,29046922,32527800",1,TFRC-related combined immunodeficiency,0.623449899069336
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.862,1,A_surface,5,66.0,0,0,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P21926,CD9,CD9 antigen,Tier 1.5,0.858,1,A_surface,5,88.56,0,0,,,1,17,"41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386",1,diphtheria,0.5261379875719714
P13591,NCAM1,Neural cell adhesion molecule 1,Tier 1.5,0.852,1,A_surface,7,79.5,0,0,,,1,1,36649818,1,smoking initiation,0.5071020926446286
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.843,1,A_surface,16,83.62,1,0,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
Q9P121,NTM,Neurotrimin,Tier 1.5,0.824,1,A_surface,2,82.38,0,0,,,1,2,"35699468,26194558",1,smoking initiation,0.41382172436739945
Q14242,SELPLG,P-selectin glycoprotein ligand 1,Tier 1.5,0.82,1,A_surface,1,50.38,0,0,,,1,1,25979951,1,glaucoma,0.40058604767334977
P08571,CD14,Monocyte differentiation antigen CD14,Tier 1.5,0.818,1,A_surface,1,84.75,0,0,,,1,14,"41636061,41542672,41140242,38477735,38280803,37162508,36716100,36475636,32589412,32515246,30900705,30563044,25483705,12498773",1,dengue disease,0.39219972762611355
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.804,1,A_surface,14,75.5,1,0,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
Q5ZPR3,CD276,CD276 antigen,Tier 1.5,0.804,1,A_surface,3,83.31,1,0,,,1,1,38866941,1,response to statin,0.3471917147958521
P08100,RHO,Rhodopsin,Tier 1.5,0.804,1,A_surface,4,88.75,1,0,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.801,1,A_surface,8,83.12,1,0,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
P10912,GHR,Growth hormone receptor,Tier 1.5,0.799,1,A_surface,9,58.69,0,0,,,1,5,"38811951,38477735,31603904",0,Laron syndrome,0.8304020079647765
Q13308,PTK7,Inactive tyrosine-protein kinase 7,Tier 1.5,0.796,1,A_surface,1,82.69,0,0,,,1,110,"41949051,41786503,41782379,41780252,41473803,41172349,41097888,41065179,41047832,40987771,40652441,40618375,40556592,40488675,40479736,40415219,40388621,40274545,40033943,39933564,39583320,39468753,39405917,39315658,39226482,39211579,39161311,39127174,38985770,38922365,38889444,38773263,38708542,38695582,38642044,38466380,38359901,38148412,38064592,37974961,37480788,37473438,37458448,37247456,37105082,37003060,36765879,36722904,36722696,36471380",1,neurodegenerative disease,0.3194172724024113
P16410,CTLA4,Cytotoxic T-lymphocyte protein 4,Tier 1.5,0.787,1,A_surface,22,80.12,0,0,,,1,26,"41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549",0,autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency,0.7906408646569979
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.785,1,A_surface,14,85.25,1,0,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
P32942,ICAM3,Intercellular adhesion molecule 3,Tier 1.5,0.785,1,A_surface,1,87.12,0,0,,,1,3,"40650261,34730968,17660953",1,lymphatic system disease,0.28331776251399693
Q96MS0,ROBO3,Roundabout homolog 3,Tier 1.5,0.784,1,A_surface,3,63.69,0,0,,,1,2,32369590,0,horizontal gaze palsy with progressive scoliosis,0.7813306356858872
P51654,GPC3,Glypican-3,Tier 1.5,0.779,1,A_surface,4,75.06,1,0,,,1,65,"42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753",0,Simpson-Golabi-Behmel syndrome type 1,0.762708583613362
P20023,CR2,Complement receptor type 2,Tier 1.5,0.776,1,A_surface,9,74.94,1,0,,,1,1,33235290,0,"immunodeficiency, common variable, 7",0.7543125403898414
P40126,DCT,L-dopachrome tautomerase,Tier 1.5,0.774,1,A_surface,1,89.12,0,0,,,1,1,27245069,0,oculocutaneous albinism type 8,0.7468868816172217
P08887,IL6R,Interleukin-6 receptor subunit alpha,Tier 1.5,0.768,1,A_surface,10,77.88,1,0,,,1,18,"40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809",0,rheumatoid arthritis,0.7269057706798291
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.767,1,A_surface,7,59.91,1,0,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P01732,CD8A,T-cell surface glycoprotein CD8 alpha chain,Tier 1.5,0.761,1,A_surface,8,78.19,0,0,,,1,2,"38487531,36979667",1,progressive supranuclear palsy,0.2036023725502463
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.76,1,A_surface,3,80.19,0,0,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P15391,CD19,B-lymphocyte antigen CD19,Tier 1.5,0.755,1,A_surface,4,62.22,1,0,,,1,13,"41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492",0,"immunodeficiency, common variable, 3",0.6821072538733047
P32970,CD70,CD70 antigen,Tier 1.5,0.75,1,A_surface,1,83.19,0,0,,,1,1,30609550,0,severe combined immunodeficiency due to CD70 deficiency,0.6651491980619259
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.748,1,A_surface,8,63.03,1,0,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.744,1,A_surface,6,67.38,0,0,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
Q8NER1,TRPV1,Transient receptor potential cation channel subfamily V member 1,Tier 1.5,0.738,1,A_surface,8,71.94,1,0,,,1,2,"40855286,28604222",0,migraine disorder,0.6269329225883602
P42658,DPP6,A-type potassium channel modulatory protein DPP6,Tier 1.5,0.737,1,A_surface,8,86.69,1,0,,,1,1,41313574,0,Autosomal dominant microcephaly,0.6225938492787458
P01876,IGHA1,Immunoglobulin heavy constant alpha 1,Tier 1.5,0.736,1,A_surface,14,81.88,1,0,,,1,2,37325361,1,IGA glomerulonephritis,0.12053726815801102
Q8N126,CADM3,Cell adhesion molecule 3,Tier 1.5,0.735,1,A_surface,1,84.38,0,0,,,1,2,39263947,0,"Charcot-Marie-Tooth disease, axonal, type 2FF",0.6157861516342734
P01877,IGHA2,Immunoglobulin heavy constant alpha 2,Tier 1.5,0.726,1,A_surface,4,83.0,1,0,,,1,2,37325361,1,Chronic mucocutaneous candidosis,0.08794784007807564
P21709,EPHA1,Ephrin type-A receptor 1,Tier 1.5,0.724,1,A_surface,4,80.38,0,0,,,1,4,"35283197,24629635,41325160",0,Alzheimer disease,0.5784090512493305
P31358,CD52,CAMPATH-1 antigen,Tier 1.5,0.723,1,A_surface,1,67.19,0,0,,,1,1,39865939,0,chronic lymphocytic leukemia,0.5770414699711784
P18627,LAG3,Lymphocyte activation gene 3 protein,Tier 1.5,0.72,1,A_surface,6,78.38,1,0,,,1,6,"40761795,38158454,36603108,28934318",0,melanoma,0.5672649687930189
P55259,GP2,Pancreatic secretory granule membrane major glycoprotein GP2,Tier 1.5,0.707,1,A_surface,4,78.62,1,0,,,1,3,"36902059,25483705,24334484",0,type 2 diabetes mellitus,0.5235291484788168
O43653,PSCA,Prostate stem cell antigen,Tier 1.5,0.706,1,A_surface,1,81.31,0,0,,,1,2,41911185,0,duodenal ulcer,0.5197329863180171