id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25054,APC,Adenomatous polyposis coli protein,Tier 1,0.644,1,A2_pm_peripheral,31,,0,0,,,1,39,"41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673",0,familial adenomatous polyposis 1,0.8462165290909345
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.644,1,A2_pm_peripheral,7,85.62,0,0,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
Q9Y215,COLQ,Acetylcholinesterase collagenic tail peptide,Tier 1.5,0.629,1,A2_pm_peripheral,1,54.47,0,0,,,0,0,,0,Congenital myasthenic syndromes,0.796199449860989
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q68CZ1,RPGRIP1L,Protein fantom,Tier 1.5,0.628,1,A2_pm_peripheral,1,70.06,0,0,,,0,0,,0,Joubert syndrome with hepatic defect,0.7930231953177929
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
O75800,ZMYND10,Zinc finger MYND domain-containing protein 10,Tier 1,0.625,1,A2_pm_peripheral,2,88.75,0,0,,,0,0,,0,primary ciliary dyskinesia,0.7822239837882315
Q86SQ9,DHDDS,Dehydrodolichyl diphosphate synthase complex subunit DHDDS,Tier 1,0.624,1,A2_pm_peripheral,9,94.75,0,0,,,0,0,,0,retinitis pigmentosa 59,0.7786578489187141
O43586,PSTPIP1,Proline-serine-threonine phosphatase-interacting protein 1,Tier 1,0.624,1,A2_pm_peripheral,4,85.75,0,0,,,0,0,,0,pyogenic arthritis-pyoderma gangrenosum-acne syndrome,0.7793785829807485
Q8NFD5,ARID1B,AT-rich interactive domain-containing protein 1B,Tier 1,0.624,1,A2_pm_peripheral,2,46.19,0,0,,,0,0,,0,Coffin-Siris syndrome 1,0.7813407475430133
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
Q15744,CEBPE,CCAAT/enhancer-binding protein epsilon,Tier 1.5,0.619,1,A2_pm_peripheral,1,63.19,0,0,,,0,0,,0,Recurrent infection due to specific granule deficiency,0.7619369036825959
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
Q96CW9,NTNG2,Netrin-G2,Tier 1.5,0.616,1,A2_pm_peripheral,3,84.5,0,0,,,0,0,,0,"neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia",0.7527757254195254
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
P48788,TNNI2,"Troponin I, fast skeletal muscle",Tier 1.5,0.613,1,A2_pm_peripheral,2,80.69,0,0,,,0,0,,0,distal arthrogryposis type 2B1,0.7424838485252128
O15350,TP73,Tumor protein p73,Tier 1,0.612,1,A2_pm_peripheral,28,65.19,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 47, and lissencephaly",0.7409037542174439
P12643,BMP2,Bone morphogenetic protein 2,Tier 1,0.611,1,A2_pm_peripheral,21,79.56,0,0,,,1,10,"41144653,38542880,37231465,35591468,35195734,34067593,33997500",0,"short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1",0.7361833785834584
O14640,DVL1,Segment polarity protein dishevelled homolog DVL-1,Tier 1.5,0.611,1,A2_pm_peripheral,3,59.84,0,0,,,1,1,37231925,0,autosomal dominant Robinow syndrome,0.7359277384599506
Q6EMB2,TTLL5,Tubulin polyglutamylase TTLL5,Tier 1.5,0.607,1,A2_pm_peripheral,1,61.41,0,0,,,0,0,,0,Cone rod dystrophy,0.72210835127064
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q8N136,DAW1,Dynein assembly factor with WD repeat domains 1,Tier 1,0.596,1,A2_pm_peripheral,1,96.62,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 52",0.6876653910907874
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.595,1,A2_pm_peripheral,1,74.94,0,0,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q4KMQ1,TPRN,Taperin,Tier 1.5,0.595,1,A2_pm_peripheral,1,54.44,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.6844134134291492
Q9H6P5,TASP1,Threonine aspartase 1,Tier 1,0.594,1,A2_pm_peripheral,10,86.81,0,0,,,0,0,,0,Suleiman-El-Hattab syndrome,0.6801464403674466
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P50607,TUB,Tubby protein homolog,Tier 1.5,0.579,1,A2_pm_peripheral,1,69.12,0,0,,,0,0,,0,retinitis pigmentosa,0.631297844631827
Q2Q1W2,TRIM71,E3 ubiquitin-protein ligase TRIM71,Tier 1.5,0.578,1,A2_pm_peripheral,2,79.12,0,0,,,1,2,31732746,0,"hydrocephalus, congenital communicating, 1",0.6276048232841862
Q9UQC2,GAB2,GRB2-associated-binding protein 2,Tier 1,0.572,1,A2_pm_peripheral,10,51.91,0,0,,,0,0,,0,cancer,0.6072358553557748
Q8IWB6,TEX14,Inactive serine/threonine-protein kinase TEX14,Tier 1,0.571,1,A2_pm_peripheral,2,50.47,0,0,,,0,0,,0,spermatogenic failure 23,0.603775324929283
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533
Q13882,PTK6,Protein-tyrosine kinase 6,Tier 1,0.56,1,A2_pm_peripheral,9,88.81,0,0,,,0,0,,0,medullary thyroid gland carcinoma,0.5657289152364859
P51813,BMX,Cytoplasmic tyrosine-protein kinase BMX,Tier 1,0.555,1,A2_pm_peripheral,6,75.75,0,0,,,1,1,34962102,0,alopecia areata,0.5491699656070116
O76083,PDE9A,"High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A",Tier 1,0.553,1,A2_pm_peripheral,25,81.0,0,0,,,0,0,,0,coronary artery disease,0.5429744031742744
Q96RU8,TRIB1,Tribbles homolog 1,Tier 1,0.552,1,A2_pm_peripheral,5,76.56,0,0,,,1,1,36579647,0,neurodegenerative disease,0.5397808385585621
Q9BVS4,RIOK2,Serine/threonine-protein kinase RIO2,Tier 1,0.552,1,A2_pm_peripheral,10,67.38,1,0,,,0,0,,0,neurodegenerative disease,0.539818754658029
Q86T24,ZBTB33,Transcriptional regulator Kaiso,Tier 1,0.551,1,A2_pm_peripheral,19,54.78,0,0,,,0,0,,0,neurodegenerative disease,0.5355170277816887
Q9NXF7,DCAF16,DDB1- and CUL4-associated factor 16,Tier 1,0.548,1,A2_pm_peripheral,2,38.19,1,0,,,0,0,,0,neurodegenerative disease,0.5251061120759617
Q8WWN9,IPCEF1,Interactor protein for cytohesin exchange factors 1,Tier 1.5,0.547,1,A2_pm_peripheral,1,64.06,0,0,,,0,0,,0,response to tramadol,0.5225136314922196
Q14678,KANK1,KN motif and ankyrin repeat domain-containing protein 1,Tier 1,0.546,1,A2_pm_peripheral,5,53.97,0,0,,,0,0,,0,basal cell carcinoma,0.5204468359739138
Q8N8R7,ARL14EP,ARL14 effector protein,Tier 1.5,0.546,1,A2_pm_peripheral,1,80.69,0,0,,,0,0,,0,endometriosis,0.5215169504121038
Q5TC82,RC3H1,Roquin-1,Tier 1,0.545,1,A2_pm_peripheral,6,61.12,0,0,,,1,2,27010430,0,"hemophagocytic lymphohistiocytosis, familial, 6",0.5161798637096334
O43663,PRC1,Protein regulator of cytokinesis 1,Tier 1,0.544,1,A2_pm_peripheral,6,78.94,1,0,,,0,0,,0,neurodegenerative disease,0.5139662839321523
P49789,FHIT,Bis(5'-adenosyl)-triphosphatase,Tier 1,0.542,1,A2_pm_peripheral,9,95.25,0,0,,,0,0,,0,Abnormality of the skeletal system,0.505651828927915
P48775,TDO2,"Tryptophan 2,3-dioxygenase",Tier 1,0.541,1,A2_pm_peripheral,22,90.06,0,0,,,0,0,,0,Hypertryptophanemia,0.5037265368575525
Q5UIP0,RIF1,Telomere-associated protein RIF1,Tier 1.5,0.541,1,A2_pm_peripheral,1,53.78,0,0,,,0,0,,0,neurodegenerative disease,0.5038900373620092
Q96AT9,RPE,Ribulose-phosphate 3-epimerase,Tier 1,0.54,1,A2_pm_peripheral,4,96.56,0,0,,,1,19,"37958909,31080896,26923800,25270019,23539459,22913867,22710369,22281826,21701525,21546514,21448811,21137477,20623466,19197318,18628724,18441313,17891009,17369776,16815269",0,neurodegenerative disease,0.4992627094132485
P11712,CYP2C9,Cytochrome P450 2C9,Tier 1,0.536,1,A2_pm_peripheral,15,92.94,0,0,,,0,0,,0,cholesterol embolism,0.4868290635834234