id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25054,APC,Adenomatous polyposis coli protein,Tier 1,0.644,1,A2_pm_peripheral,31,,0,0,,,1,39,"41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673",0,familial adenomatous polyposis 1,0.8462165290909345
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
O75800,ZMYND10,Zinc finger MYND domain-containing protein 10,Tier 1,0.625,1,A2_pm_peripheral,2,88.75,0,0,,,0,0,,0,primary ciliary dyskinesia,0.7822239837882315
Q86SQ9,DHDDS,Dehydrodolichyl diphosphate synthase complex subunit DHDDS,Tier 1,0.624,1,A2_pm_peripheral,9,94.75,0,0,,,0,0,,0,retinitis pigmentosa 59,0.7786578489187141
O43586,PSTPIP1,Proline-serine-threonine phosphatase-interacting protein 1,Tier 1,0.624,1,A2_pm_peripheral,4,85.75,0,0,,,0,0,,0,pyogenic arthritis-pyoderma gangrenosum-acne syndrome,0.7793785829807485
Q8NFD5,ARID1B,AT-rich interactive domain-containing protein 1B,Tier 1,0.624,1,A2_pm_peripheral,2,46.19,0,0,,,0,0,,0,Coffin-Siris syndrome 1,0.7813407475430133
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
O15350,TP73,Tumor protein p73,Tier 1,0.612,1,A2_pm_peripheral,28,65.19,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 47, and lissencephaly",0.7409037542174439
P12643,BMP2,Bone morphogenetic protein 2,Tier 1,0.611,1,A2_pm_peripheral,21,79.56,0,0,,,1,10,"41144653,38542880,37231465,35591468,35195734,34067593,33997500",0,"short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1",0.7361833785834584
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q8N136,DAW1,Dynein assembly factor with WD repeat domains 1,Tier 1,0.596,1,A2_pm_peripheral,1,96.62,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 52",0.6876653910907874
Q9H6P5,TASP1,Threonine aspartase 1,Tier 1,0.594,1,A2_pm_peripheral,10,86.81,0,0,,,0,0,,0,Suleiman-El-Hattab syndrome,0.6801464403674466
Q9UQC2,GAB2,GRB2-associated-binding protein 2,Tier 1,0.572,1,A2_pm_peripheral,10,51.91,0,0,,,0,0,,0,cancer,0.6072358553557748
Q8IWB6,TEX14,Inactive serine/threonine-protein kinase TEX14,Tier 1,0.571,1,A2_pm_peripheral,2,50.47,0,0,,,0,0,,0,spermatogenic failure 23,0.603775324929283
Q13882,PTK6,Protein-tyrosine kinase 6,Tier 1,0.56,1,A2_pm_peripheral,9,88.81,0,0,,,0,0,,0,medullary thyroid gland carcinoma,0.5657289152364859
P51813,BMX,Cytoplasmic tyrosine-protein kinase BMX,Tier 1,0.555,1,A2_pm_peripheral,6,75.75,0,0,,,1,1,34962102,0,alopecia areata,0.5491699656070116
O76083,PDE9A,"High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A",Tier 1,0.553,1,A2_pm_peripheral,25,81.0,0,0,,,0,0,,0,coronary artery disease,0.5429744031742744
Q96RU8,TRIB1,Tribbles homolog 1,Tier 1,0.552,1,A2_pm_peripheral,5,76.56,0,0,,,1,1,36579647,0,neurodegenerative disease,0.5397808385585621
Q9BVS4,RIOK2,Serine/threonine-protein kinase RIO2,Tier 1,0.552,1,A2_pm_peripheral,10,67.38,1,0,,,0,0,,0,neurodegenerative disease,0.539818754658029
Q86T24,ZBTB33,Transcriptional regulator Kaiso,Tier 1,0.551,1,A2_pm_peripheral,19,54.78,0,0,,,0,0,,0,neurodegenerative disease,0.5355170277816887
Q9NXF7,DCAF16,DDB1- and CUL4-associated factor 16,Tier 1,0.548,1,A2_pm_peripheral,2,38.19,1,0,,,0,0,,0,neurodegenerative disease,0.5251061120759617
Q14678,KANK1,KN motif and ankyrin repeat domain-containing protein 1,Tier 1,0.546,1,A2_pm_peripheral,5,53.97,0,0,,,0,0,,0,basal cell carcinoma,0.5204468359739138
Q5TC82,RC3H1,Roquin-1,Tier 1,0.545,1,A2_pm_peripheral,6,61.12,0,0,,,1,2,27010430,0,"hemophagocytic lymphohistiocytosis, familial, 6",0.5161798637096334
O43663,PRC1,Protein regulator of cytokinesis 1,Tier 1,0.544,1,A2_pm_peripheral,6,78.94,1,0,,,0,0,,0,neurodegenerative disease,0.5139662839321523
P49789,FHIT,Bis(5'-adenosyl)-triphosphatase,Tier 1,0.542,1,A2_pm_peripheral,9,95.25,0,0,,,0,0,,0,Abnormality of the skeletal system,0.505651828927915
P48775,TDO2,"Tryptophan 2,3-dioxygenase",Tier 1,0.541,1,A2_pm_peripheral,22,90.06,0,0,,,0,0,,0,Hypertryptophanemia,0.5037265368575525
Q96AT9,RPE,Ribulose-phosphate 3-epimerase,Tier 1,0.54,1,A2_pm_peripheral,4,96.56,0,0,,,1,19,"37958909,31080896,26923800,25270019,23539459,22913867,22710369,22281826,21701525,21546514,21448811,21137477,20623466,19197318,18628724,18441313,17891009,17369776,16815269",0,neurodegenerative disease,0.4992627094132485
P11712,CYP2C9,Cytochrome P450 2C9,Tier 1,0.536,1,A2_pm_peripheral,15,92.94,0,0,,,0,0,,0,cholesterol embolism,0.4868290635834234
Q15788,NCOA1,Nuclear receptor coactivator 1,Tier 1,0.536,1,A2_pm_peripheral,100,46.72,0,0,,,0,0,,0,neurodegenerative disease,0.48697450901885614
Q96MU7,YTHDC1,YTH domain-containing protein 1,Tier 1,0.533,1,A2_pm_peripheral,100,60.34,0,0,,,1,1,41430607,0,neurodegenerative disease,0.47698771849556626
O14733,MAP2K7,Dual specificity mitogen-activated protein kinase kinase 7,Tier 1,0.529,1,A2_pm_peripheral,37,77.25,0,0,,,0,0,,0,neurodegenerative disease,0.4624505042962164
P43351,RAD52,DNA repair protein RAD52 homolog,Tier 1,0.528,1,A2_pm_peripheral,11,69.62,1,0,,,1,6,"37288783,32945515,31495919,26784987,24500205,23836560",0,Abnormality of the skeletal system,0.45994164258033876
Q9BX66,SORBS1,Sorbin and SH3 domain-containing protein 1,Tier 1,0.527,1,A2_pm_peripheral,11,46.94,0,0,,,0,0,,0,neurodegenerative disease,0.45582260952481995
Q9UK80,USP21,Ubiquitin carboxyl-terminal hydrolase 21,Tier 1,0.524,1,A2_pm_peripheral,4,69.75,1,0,,,0,0,,0,neurodegenerative disease,0.44616960950164986
O00757,FBP2,"Fructose-1,6-bisphosphatase isozyme 2",Tier 1,0.523,1,A2_pm_peripheral,14,93.75,0,0,,,0,0,,0,"leukodystrophy, childhood-onset, remitting",0.44205857063120163
O15519,CFLAR,CASP8 and FADD-like apoptosis regulator,Tier 1,0.523,1,A2_pm_peripheral,17,78.31,1,0,,,0,0,,0,neurodegenerative disease,0.4419421569940659
Q12923,PTPN13,Tyrosine-protein phosphatase non-receptor type 13,Tier 1,0.519,1,A2_pm_peripheral,12,60.03,0,0,,,0,0,,0,Abnormality of the skeletal system,0.43005634671382553
P29475,NOS1,Nitric oxide synthase 1,Tier 1,0.514,1,A2_pm_peripheral,100,79.31,0,0,,,0,0,,0,cervical carcinoma,0.41359915410428943
Q7Z6G8,ANKS1B,Ankyrin repeat and sterile alpha motif domain-containing protein 1B,Tier 1,0.511,1,A2_pm_peripheral,4,56.94,0,0,,,0,0,,0,alcohol drinking,0.4042006937895571
Q15700,DLG2,Disks large homolog 2,Tier 1,0.51,1,A2_pm_peripheral,2,69.94,0,0,,,0,0,,0,alcohol drinking,0.40008157091117924
P33260,CYP2C18,Cytochrome P450 2C18,Tier 1,0.507,1,A2_pm_peripheral,2,93.81,0,0,,,0,0,,0,response to anticoagulant,0.3915927978813387
Q9UQF2,MAPK8IP1,C-Jun-amino-terminal kinase-interacting protein 1,Tier 1,0.506,1,A2_pm_peripheral,27,54.03,0,0,,,0,0,,0,neurodegenerative disease,0.3877056074053897
O00451,GFRA2,GDNF family receptor alpha-2,Tier 1,0.487,1,A2_pm_peripheral,5,75.0,1,0,,,0,0,,0,poisoning,0.32401333746089783
Q5SZJ8,BEND6,BEN domain-containing protein 6,Tier 1,0.486,1,A2_pm_peripheral,2,71.81,0,0,,,0,0,,0,muscle cramp,0.3185460431293047
Q8N5Z0,AADAT,"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial",Tier 1,0.485,1,A2_pm_peripheral,17,97.31,0,0,,,0,0,,0,retinopathy,0.31774809840020035
P59768,GNG2,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Tier 1,0.485,1,A2_pm_peripheral,100,89.56,1,0,,,0,0,,0,multiple sclerosis,0.3157760490336847
Q6ZSG1,ARK2C,E3 ubiquitin-protein ligase ARK2C,Tier 1,0.482,1,A2_pm_peripheral,9,57.0,0,0,,,0,0,,0,protozoa infectious disease,0.30575954222879614