id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.644,1,A2_pm_peripheral,7,85.62,0,0,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
Q9Y215,COLQ,Acetylcholinesterase collagenic tail peptide,Tier 1.5,0.629,1,A2_pm_peripheral,1,54.47,0,0,,,0,0,,0,Congenital myasthenic syndromes,0.796199449860989
Q68CZ1,RPGRIP1L,Protein fantom,Tier 1.5,0.628,1,A2_pm_peripheral,1,70.06,0,0,,,0,0,,0,Joubert syndrome with hepatic defect,0.7930231953177929
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
Q15744,CEBPE,CCAAT/enhancer-binding protein epsilon,Tier 1.5,0.619,1,A2_pm_peripheral,1,63.19,0,0,,,0,0,,0,Recurrent infection due to specific granule deficiency,0.7619369036825959
Q96CW9,NTNG2,Netrin-G2,Tier 1.5,0.616,1,A2_pm_peripheral,3,84.5,0,0,,,0,0,,0,"neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia",0.7527757254195254
P48788,TNNI2,"Troponin I, fast skeletal muscle",Tier 1.5,0.613,1,A2_pm_peripheral,2,80.69,0,0,,,0,0,,0,distal arthrogryposis type 2B1,0.7424838485252128
O14640,DVL1,Segment polarity protein dishevelled homolog DVL-1,Tier 1.5,0.611,1,A2_pm_peripheral,3,59.84,0,0,,,1,1,37231925,0,autosomal dominant Robinow syndrome,0.7359277384599506
Q6EMB2,TTLL5,Tubulin polyglutamylase TTLL5,Tier 1.5,0.607,1,A2_pm_peripheral,1,61.41,0,0,,,0,0,,0,Cone rod dystrophy,0.72210835127064
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.595,1,A2_pm_peripheral,1,74.94,0,0,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q4KMQ1,TPRN,Taperin,Tier 1.5,0.595,1,A2_pm_peripheral,1,54.44,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.6844134134291492
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P50607,TUB,Tubby protein homolog,Tier 1.5,0.579,1,A2_pm_peripheral,1,69.12,0,0,,,0,0,,0,retinitis pigmentosa,0.631297844631827
Q2Q1W2,TRIM71,E3 ubiquitin-protein ligase TRIM71,Tier 1.5,0.578,1,A2_pm_peripheral,2,79.12,0,0,,,1,2,31732746,0,"hydrocephalus, congenital communicating, 1",0.6276048232841862
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533
Q8WWN9,IPCEF1,Interactor protein for cytohesin exchange factors 1,Tier 1.5,0.547,1,A2_pm_peripheral,1,64.06,0,0,,,0,0,,0,response to tramadol,0.5225136314922196
Q8N8R7,ARL14EP,ARL14 effector protein,Tier 1.5,0.546,1,A2_pm_peripheral,1,80.69,0,0,,,0,0,,0,endometriosis,0.5215169504121038
Q5UIP0,RIF1,Telomere-associated protein RIF1,Tier 1.5,0.541,1,A2_pm_peripheral,1,53.78,0,0,,,0,0,,0,neurodegenerative disease,0.5038900373620092
Q9GZN1,ACTR6,Actin-related protein 6,Tier 1.5,0.533,1,A2_pm_peripheral,9,94.31,1,0,,,0,0,,0,neurodegenerative disease,0.4758409073452339
Q9UKI9,POU2F3,"POU domain, class 2, transcription factor 3",Tier 1.5,0.523,1,A2_pm_peripheral,3,59.34,0,0,,,0,0,,0,erythematosquamous dermatosis,0.44361239146188985
O75747,PIK3C2G,Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma,Tier 1.5,0.523,1,A2_pm_peripheral,1,73.62,0,0,,,0,0,,0,mathematical ability,0.4448369190532247
Q9Y2I2,NTNG1,Netrin-G1,Tier 1.5,0.522,1,A2_pm_peripheral,1,83.62,0,0,,,0,0,,0,obesity,0.438954995963001
O95149,SNUPN,Snurportin-1,Tier 1.5,0.518,1,A2_pm_peripheral,11,82.81,0,0,,,0,0,,0,"muscular dystrophy, limb-girdle, autosomal recessive 29",0.42732670697918645
Q5VTH2,CFAP126,Protein Flattop,Tier 1.5,0.51,1,A2_pm_peripheral,2,72.62,1,0,,,0,0,,0,hereditary pheochromocytoma-paraganglioma,0.4009925718465981
Q9Y2K6,USP20,Ubiquitin carboxyl-terminal hydrolase 20,Tier 1.5,0.509,1,A2_pm_peripheral,1,72.31,0,0,,,1,1,30863411,0,connective tissue neoplasm,0.3981371748391643
O95049,TJP3,Tight junction protein ZO-3,Tier 1.5,0.508,1,A2_pm_peripheral,1,66.81,0,0,,,0,0,,0,neurodegenerative disease,0.3927046238887248
Q6ZUJ8,PIK3AP1,Phosphoinositide 3-kinase adapter protein 1,Tier 1.5,0.507,1,A2_pm_peripheral,2,64.94,0,0,,,0,0,,0,neurodegenerative disease,0.39164159393726217
Q14CW9,ATXN7L3,Ataxin-7-like protein 3,Tier 1.5,0.501,1,A2_pm_peripheral,1,65.44,0,0,,,0,0,,0,neurodegenerative disease,0.3695798546847018
Q9HCH5,SYTL2,Synaptotagmin-like protein 2,Tier 1.5,0.501,1,A2_pm_peripheral,9,57.72,0,0,,,0,0,,0,obstructive sleep apnea,0.36964540101000476
Q9UQK1,PPP1R3C,Protein phosphatase 1 regulatory subunit 3C,Tier 1.5,0.501,1,A2_pm_peripheral,4,67.62,0,0,,,0,0,,0,disorder of glycogen metabolism,0.3695798546847018
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
P58340,MLF1,Myeloid leukemia factor 1,Tier 1.5,0.501,1,A2_pm_peripheral,3,67.0,0,0,,,0,0,,0,lymphoid neoplasm,0.3695798546847018
P32298,GRK4,G protein-coupled receptor kinase 4,Tier 1.5,0.49,1,A2_pm_peripheral,1,88.69,0,0,,,1,2,31555351,0,Nausea and vomiting,0.33267400228074584
P10632,CYP2C8,Cytochrome P450 2C8,Tier 1.5,0.486,1,A2_pm_peripheral,5,93.06,0,0,,,0,0,,0,Abnormality of the skeletal system,0.3211518152079769
Q9ULJ8,PPP1R9A,Neurabin-1,Tier 1.5,0.476,1,A2_pm_peripheral,2,59.62,0,0,,,0,0,,0,myeloid leukemia,0.28568410491371843
P57771,RGS8,Regulator of G-protein signaling 8,Tier 1.5,0.474,1,A2_pm_peripheral,3,81.25,0,0,,,0,0,,0,Hematemesis,0.28069850888564046
O75604,USP2,Ubiquitin carboxyl-terminal hydrolase 2,Tier 1.5,0.469,1,A2_pm_peripheral,8,68.12,0,0,,,0,0,,0,refractive error,0.26457439923389525
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556
Q8N448,LNX2,Ligand of Numb protein X 2,Tier 1.5,0.448,1,A2_pm_peripheral,7,74.62,0,0,,,0,0,,0,exostosis,0.19343380355753698
P19957,PI3,Elafin,Tier 1.5,0.446,1,A2_pm_peripheral,3,72.25,0,0,,,1,3,"37351609,36517803,30087279",0,Abruptio Placentae,0.18626794135552627
Q9UFD9,RIMBP3,RIMS-binding protein 3A,Tier 1.5,0.421,1,A2_pm_peripheral,1,57.53,0,0,,,0,0,,0,azoospermia,0.10375257721432407
Q5T1H1,EYS,Protein eyes shut homolog,Tier 1.5,0.39,0,A2_pm_peripheral,0,56.53,0,0,,,0,0,,0,retinitis pigmentosa,0.8167306715305448
Q86UC2,RSPH3,Radial spoke head protein 3 homolog,Tier 1.5,0.39,1,A2_pm_peripheral,1,64.62,1,0,,,0,0,,0,,
P98174,FGD1,"FYVE, RhoGEF and PH domain-containing protein 1",Tier 1.5,0.389,0,A2_pm_peripheral,0,64.81,0,0,,,0,0,,0,"Aarskog-Scott syndrome, X-linked",0.8139881587444686
Q9H4F8,SMOC1,SPARC-related modular calcium-binding protein 1,Tier 1.5,0.388,0,A2_pm_peripheral,0,73.31,0,0,,,1,1,36333824,0,microphthalmia with limb anomalies,0.8103774498041117
Q92539,LPIN2,Phosphatidate phosphatase LPIN2,Tier 1.5,0.385,0,A2_pm_peripheral,0,60.5,0,0,,,0,0,,0,Majeed syndrome,0.8006214215390607
O75061,DNAJC6,Auxilin,Tier 1.5,0.38,0,A2_pm_peripheral,0,62.88,0,0,,,0,0,,0,Young adult-onset Parkinsonism,0.784924972265951
Q9UHK6,AMACR,Alpha-methylacyl-CoA racemase,Tier 1.5,0.374,0,A2_pm_peripheral,0,95.81,0,0,,,1,10,"40271962,35780537,35539643,26547498,24994506",0,Alpha-methylacyl-CoA racemase deficiency,0.762086344446303
Q5VTD9,GFI1B,Zinc finger protein Gfi-1b,Tier 1.5,0.365,0,A2_pm_peripheral,0,63.81,0,0,,,0,0,,0,platelet-type bleeding disorder 17,0.7329750493288353