id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q00604,NDP,Norrin,Tier 1.5,0.707,1,A_assoc,11,83.56,1,0,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,Tier 1.5,0.697,1,A_assoc,9,92.56,1,0,,,0,0,,0,autosomal dominant epilepsy with auditory features,0.8225657483127345
Q13253,NOG,Noggin,Tier 1.5,0.685,1,A_assoc,2,86.06,0,0,,,1,2,38397086,0,proximal symphalangism 1A,0.7844136456463046
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.685,1,A_assoc,3,68.62,1,0,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.684,1,A_assoc,8,73.25,0,0,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.682,1,A_assoc,5,87.06,0,0,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
P29120,PCSK1,Neuroendocrine convertase 1,Tier 1.5,0.682,1,A_assoc,3,82.5,0,0,,,0,0,,0,obesity due to prohormone convertase I deficiency,0.773875795833803
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.677,1,A_assoc,4,51.91,0,0,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
P55789,GFER,FAD-linked sulfhydryl oxidase ALR,Tier 1.5,0.677,1,A_assoc,7,76.88,0,0,,,0,0,,0,congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome,0.7556346526616893
Q12794,HYAL1,Hyaluronidase-1,Tier 1.5,0.672,1,A_assoc,1,94.0,0,0,,,0,0,,0,Hyaluronidase deficiency,0.7412407206736383
Q92752,TNR,Tenascin-R,Tier 1.5,0.672,1,A_assoc,2,78.5,0,0,,,0,0,,0,"neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus",0.7403484347367364
O15520,FGF10,Fibroblast growth factor 10,Tier 1.5,0.67,1,A_assoc,2,80.0,0,0,,,1,1,35415885,0,Lacrimoauriculodentodigital syndrome,0.7344198619465704
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,Tier 1.5,0.666,1,A_assoc,1,86.5,0,0,,,1,1,15562003,0,juvenile Paget disease,0.7184894548525037
P11686,SFTPC,Surfactant protein C,Tier 1.5,0.663,1,A_assoc,3,70.06,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7110128683619542
O43897,TLL1,,Tier 1.5,0.662,1,A_assoc,1,80.31,0,0,,,0,0,,0,atrial heart septal defect,0.7050140477090344
P19835,CEL,Bile salt-activated lipase,Tier 1.5,0.658,1,A_assoc,7,82.56,0,0,,,1,2,"39653009,34940276",0,MODY,0.6940743944678538
P27352,CBLIF,Cobalamin binding intrinsic factor,Tier 1.5,0.655,1,A_assoc,2,90.5,0,0,,,0,0,,0,hereditary intrinsic factor deficiency,0.683930100359911
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.652,1,A_assoc,1,79.62,0,0,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
O95631,NTN1,Netrin-1,Tier 1.5,0.648,1,A_assoc,5,88.5,1,0,,,0,0,,0,mirror movements 4,0.6611393488240481
O76093,FGF18,Fibroblast growth factor 18,Tier 1.5,0.631,1,A_assoc,1,87.56,0,0,,,1,1,35415885,0,cancer,0.6028027301556572
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.631,1,A_assoc,1,81.5,0,0,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
Q15818,NPTX1,Neuronal pentraxin-1,Tier 1.5,0.628,1,A_assoc,1,75.75,0,0,,,0,0,,0,spinocerebellar ataxia 50,0.5937598292127286
P07098,LIPF,Gastric triacylglycerol lipase,Tier 1.5,0.626,1,A_assoc,1,89.75,0,0,,,0,0,,0,obesity,0.5864662753480862
Q6IBW4,NCAPH2,Condensin-2 complex subunit H2,Tier 1.5,0.62,1,A_assoc,1,62.41,1,0,,,0,0,,0,"cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1",0.5674645203025676
Q9GZX6,IL22,Interleukin-22,Tier 1.5,0.619,1,A_assoc,6,88.12,0,0,,,1,7,"34208021,33869115,28942363,26792955,37041650",0,atopic eczema,0.5627493881195745
Q15726,KISS1,Metastasis-suppressor KiSS-1,Tier 1.5,0.618,1,A_assoc,2,59.41,1,0,,,1,1,35026192,0,hypogonadotropic hypogonadism,0.5608645918536114
O00175,CCL24,C-C motif chemokine 24,Tier 1.5,0.613,1,A_assoc,2,82.12,0,0,,,0,0,,0,Iron deficiency anemia,0.5428194908352497
P22466,GAL,Galanin peptides,Tier 1.5,0.613,1,A_assoc,10,66.56,1,0,,,1,27,"40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673",0,temporal lobe epilepsy,0.5442263564708273
P56703,WNT3,Proto-oncogene Wnt-3,Tier 1.5,0.608,1,A_assoc,1,88.25,0,0,,,1,2,"40168709,18673242",0,neurodegenerative disease,0.5272184953415704
Q9ULL8,SHROOM4,Protein Shroom4,Tier 1.5,0.593,1,A_assoc,1,47.09,0,0,,,0,0,,0,"X-linked intellectual disability, Stocco dos Santos type",0.4759334640315342
P24855,DNASE1,Deoxyribonuclease-1,Tier 1.5,0.591,1,A_assoc,1,94.25,0,0,,,1,1,36838023,0,systemic lupus erythematosus,0.4692224712894944
P28039,AOAH,Acyloxyacyl hydrolase,Tier 1.5,0.585,1,A_assoc,2,90.38,0,0,,,0,0,,0,type 2 diabetes mellitus,0.4486206035972812
P41271,NBL1,Neuroblastoma suppressor of tumorigenicity 1,Tier 1.5,0.585,1,A_assoc,2,75.75,0,0,,,1,2,"35026285,29281176",0,nontoxic goiter,0.44859094265791405
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.583,1,A_assoc,4,76.19,0,0,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P11684,SCGB1A1,Uteroglobin,Tier 1.5,0.581,1,A_assoc,2,88.56,0,0,,,0,0,,0,chronic obstructive pulmonary disease,0.43588476688573263
Q63HQ2,EGFLAM,Pikachurin,Tier 1.5,0.574,1,A_assoc,3,80.56,1,0,,,0,0,,0,mathematical ability,0.41387833248094535
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.573,1,A_assoc,4,75.62,1,0,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
Q13007,IL24,Interleukin-24,Tier 1.5,0.572,1,A_assoc,2,83.38,0,0,,,0,0,,0,clear cell renal carcinoma,0.4074364261926763
Q96A83,COL26A1,Collagen alpha-1(XXVI) chain,Tier 1.5,0.568,1,A_assoc,6,59.66,0,0,,,0,0,,0,Inguinal hernia,0.39338285604421097
Q9UNH6,SNX7,Sorting nexin-7,Tier 1.5,0.567,1,A_assoc,1,85.81,0,0,,,0,0,,0,mathematical ability,0.3890274527063968
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.566,1,A_assoc,4,79.81,0,0,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
P20783,NTF3,Neurotrophin-3,Tier 1.5,0.565,1,A_assoc,5,73.75,0,0,,,0,0,,0,cancer,0.3844129381329447
P32881,IFNA8,Interferon alpha-8,Tier 1.5,0.563,1,A_assoc,1,84.62,0,0,,,0,0,,0,renal cell carcinoma,0.375708720608223
Q9UM21,MGAT4A,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A",Tier 1.5,0.561,1,A_assoc,1,85.25,0,0,,,0,0,,0,COVID-19,0.37050380432141355
Q16674,MIA,Melanoma-derived growth regulatory protein,Tier 1.5,0.559,1,A_assoc,4,86.38,0,0,,,1,15,"41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019",0,neurodegenerative disease,0.36367051545295126
Q8NBI3,DRAXIN,Draxin,Tier 1.5,0.558,1,A_assoc,1,58.47,0,0,,,0,0,,0,neurodegenerative disease,0.3590692945691625
P09466,PAEP,Glycodelin,Tier 1.5,0.552,1,A_assoc,1,86.75,0,0,,,0,0,,0,Kleefstra syndrome 1,0.3400134663099256
P01282,VIP,VIP peptides,Tier 1.5,0.55,1,A_assoc,5,67.62,1,0,,,1,24,"41292425,40957130,40403614,40056883,39952883,38763821,37527574,36669289,36129574,35879297,35436736,33990848,33688885,31689596,31403149,30167802,30069577,29708252,28441340,27542489,27334718,27088368,26802746,25782595",0,uterine fibroid,0.3332844575068197
O95711,LY86,Lymphocyte antigen 86,Tier 1.5,0.548,1,A_assoc,1,87.06,0,0,,,1,1,40396427,0,intestinal infectious disease,0.3265929422261205
P14316,IRF2,Interferon regulatory factor 2,Tier 1.5,0.546,1,A_assoc,1,63.94,0,0,,,0,0,,0,Abnormality of the skeletal system,0.3207414319892803