id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P13569,CFTR,Cystic fibrosis transmembrane conductance regulator,Tier 1,0.824,1,A_surface,58,75.62,1,0,,,1,10,"41148207,31029337,30595527,22483890,15657417",0,cystic fibrosis,0.9133535862571094
Q14654,KCNJ11,ATP-sensitive inward rectifier potassium channel 11,Tier 1,0.81,1,A_surface,9,83.81,1,0,,,0,0,,0,type 2 diabetes mellitus,0.8651421397012851
P07949,RET,Proto-oncogene tyrosine-protein kinase receptor Ret,Tier 1,0.809,1,A_surface,34,78.81,1,0,,,1,83,"41962371,41744190,41636718,41526122,41406741,41171123,41082837,41060784,41027166,40932619,40815127,40711581,40633058,40602121,40410423,40285964,40252505,40222299,39344894,39288589,39190775,38953438,38876068,38852325,38718747,38604287,38354543,38282384,38237282,37851382,37774402,37757695,37437453,37245460,36952259,36315022,35550937,35420408,34342436,34132907,34016094,33513536,33462661,33119785,33011620,32760976,32527800,32212604,32138930,31897454",0,medullary thyroid gland carcinoma,0.8617460262224842
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,Tier 1,0.806,1,A_surface,23,62.75,1,0,,,1,1,22617876,0,Romano-Ward syndrome,0.8549238933917284
P82251,SLC7A9,"b(0,+)-type amino acid transporter 1",Tier 1,0.805,1,A_surface,4,85.44,1,0,,,0,0,,0,cystinuria,0.8484952668941285
Q695T7,SLC6A19,Sodium-dependent neutral amino acid transporter B(0)AT1,Tier 1,0.804,1,A_surface,19,90.0,1,0,,,0,0,,0,Hartnup disease,0.8464240093600148
P41180,CASR,Extracellular calcium-sensing receptor,Tier 1,0.804,1,A_surface,31,75.69,1,0,,,0,0,,0,familial hypocalciuric hypercalcemia 1,0.8460848589627423
Q05586,GRIN1,"Glutamate receptor ionotropic, NMDA 1",Tier 1,0.803,1,A_surface,84,82.88,1,0,,,0,0,,0,"neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant",0.8446685494288694
P07911,UMOD,Uromodulin,Tier 1,0.803,1,A_surface,10,82.94,1,0,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
O43526,KCNQ2,Potassium voltage-gated channel subfamily KQT member 2,Tier 1,0.803,1,A_surface,24,58.19,1,0,,,0,0,,0,Benign familial neonatal seizures,0.8423358217314708
P07333,CSF1R,Macrophage colony-stimulating factor 1 receptor,Tier 1,0.802,1,A_surface,26,77.81,0,0,,,1,1,29277631,0,"leukoencephalopathy, diffuse hereditary, with spheroids 1",0.8391971566583056
Q9HBA0,TRPV4,Transient receptor potential cation channel subfamily V member 4,Tier 1,0.801,1,A_surface,19,71.62,1,0,,,0,0,,0,metatropic dysplasia,0.8356240344517467
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.8,1,A_surface,16,84.94,0,0,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P16473,TSHR,Thyrotropin receptor,Tier 1,0.8,1,A_surface,9,74.0,1,0,,,1,6,"41054857,40997970,40588369,38650837",0,hypothyroidism due to TSH receptor mutations,0.8327127196409464
Q92736,RYR2,Ryanodine receptor 2,Tier 1,0.8,1,A_surface,26,,1,0,,,1,1,24130701,0,catecholaminergic polymorphic ventricular tachycardia 1,0.8338648743498255
Q8IZF0,NALCN,Sodium leak channel NALCN,Tier 1,0.796,1,A_surface,5,76.69,1,0,,,0,0,,0,"congenital contractures of the limbs and face, hypotonia, and developmental delay",0.8198033442161259
P41181,AQP2,Aquaporin-2,Tier 1,0.795,1,A_surface,7,91.75,1,0,,,0,0,,0,"diabetes insipidus, nephrogenic, autosomal",0.817870726313342
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.795,1,A_surface,11,84.31,1,0,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,Tier 1,0.795,1,A_surface,7,62.0,1,0,,,1,2,"25870409,25558474",0,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897
Q01974,ROR2,Tyrosine-protein kinase transmembrane receptor ROR2,Tier 1,0.794,1,A_surface,6,68.31,0,0,,,1,2,"41782379,18673242",0,autosomal recessive Robinow syndrome,0.8145559265435566
Q9H222,ABCG5,ATP-binding cassette sub-family G member 5,Tier 1,0.793,1,A_surface,8,85.06,1,0,,,0,0,,0,sitosterolemia,0.810555184820483
Q9UM73,ALK,ALK tyrosine kinase receptor,Tier 1,0.791,1,A_surface,79,68.19,0,0,,,1,6,"40347134,38604287,32218299,29205808,24116381,21281497",0,neuroblastoma,0.8016889264946979
Q12866,MERTK,Tyrosine-protein kinase Mer,Tier 1,0.79,1,A_surface,42,72.25,0,0,,,0,0,,0,retinitis pigmentosa,0.7985580877708576
Q4KMG0,CDON,Cell adhesion molecule-related/down-regulated by oncogenes,Tier 1,0.79,1,A_surface,3,62.03,0,0,,,1,3,"36333824,24629635,18698484",0,holoprosencephaly,0.800378039564866
Q9H1D0,TRPV6,Transient receptor potential cation channel subfamily V member 6,Tier 1,0.789,1,A_surface,24,80.56,1,0,,,0,0,,0,"hyperparathyroidism, transient neonatal",0.7964821997780153
P16871,IL7R,Interleukin-7 receptor subunit alpha,Tier 1,0.789,1,A_surface,8,67.44,0,0,,,0,0,,0,immunodeficiency 104,0.7983119488718231
P15509,CSF2RA,Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,Tier 1,0.788,1,A_surface,2,82.0,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7922592394513138
Q14028,CNGB1,Cyclic nucleotide-gated channel beta-1,Tier 1,0.788,1,A_surface,11,57.66,1,0,,,0,0,,0,retinitis pigmentosa,0.7931901344765326
P22223,CDH3,Cadherin-3,Tier 1,0.786,1,A_surface,19,76.75,0,0,,,1,1,41304780,0,EEM syndrome,0.7851776755128059
P24530,EDNRB,Endothelin receptor type B,Tier 1,0.786,1,A_surface,17,75.0,1,0,,,0,0,,0,Waardenburg syndrome type 4A,0.7874601728728147
Q03431,PTH1R,Parathyroid hormone/parathyroid hormone-related peptide receptor,Tier 1,0.786,1,A_surface,52,70.94,1,0,,,0,0,,0,"metaphyseal chondrodysplasia, Jansen type",0.7859378587442476
O60741,HCN1,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Tier 1,0.786,1,A_surface,12,68.94,1,0,,,0,0,,0,Generalized epilepsy with febrile seizures-plus,0.7853938745545654
O43909,EXTL3,Exostosin-like 3,Tier 1,0.785,1,A_surface,4,83.69,1,0,,,0,0,,0,immunoskeletal dysplasia with neurodevelopmental abnormalities,0.7837827977649315
P22888,LHCGR,Lutropin-choriogonadotropic hormone receptor,Tier 1,0.785,1,A_surface,4,80.12,1,0,,,0,0,,0,"Leydig cell hypoplasia, type 1",0.783461117057047
P23416,GLRA2,Glycine receptor subunit alpha-2,Tier 1,0.784,1,A_surface,13,83.81,1,0,,,0,0,,0,"intellectual developmental disorder, X-linked, syndromic, Pilorge type",0.7805605973560554
P56696,KCNQ4,Potassium voltage-gated channel subfamily KQT member 4,Tier 1,0.783,1,A_surface,13,65.25,1,0,,,0,0,,0,autosomal dominant nonsyndromic hearing loss 2A,0.7765455627642878
Q13224,GRIN2B,"Glutamate receptor ionotropic, NMDA 2B",Tier 1,0.783,1,A_surface,36,60.69,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 6",0.7771650025965382
P30531,SLC6A1,Sodium- and chloride-dependent GABA transporter 1,Tier 1,0.782,1,A_surface,5,87.94,1,0,,,0,0,,0,epilepsy with myoclonic atonic seizures,0.7729414443362785
Q9H251,CDH23,Cadherin-23,Tier 1,0.781,1,A_surface,6,76.75,0,0,,,0,0,,0,Usher syndrome type 1,0.7713456285400272
Q9NY46,SCN3A,Sodium channel protein type 3 subunit alpha,Tier 1,0.781,1,A_surface,2,68.25,1,0,,,0,0,,0,familial focal epilepsy with variable foci,0.7708874082891223
P43220,GLP1R,Glucagon-like peptide 1 receptor,Tier 1,0.78,1,A_surface,70,81.5,1,0,,,1,2,"40691365,30957581",0,type 2 diabetes mellitus,0.7667004144705459
Q07699,SCN1B,Sodium channel regulatory subunit beta-1,Tier 1,0.779,1,A_surface,36,87.06,1,0,,,0,0,,0,Generalized epilepsy with febrile seizures-plus,0.7638796221342504
P21579,SYT1,Synaptotagmin-1,Tier 1,0.779,1,A_surface,24,81.81,0,0,,,0,0,,0,infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome,0.7640586502824556
Q01668,CACNA1D,Voltage-dependent L-type calcium channel subunit alpha-1D,Tier 1,0.777,1,A_surface,6,64.31,1,0,,,0,0,,0,aldosterone-producing adenoma with seizures and neurological abnormalities,0.7565859403082721
P30518,AVPR2,Vasopressin V2 receptor,Tier 1,0.776,1,A_surface,38,76.0,1,0,,,0,0,,0,nephrogenic syndrome of inappropriate antidiuresis,0.7522383646690638
O15399,GRIN2D,"Glutamate receptor ionotropic, NMDA 2D",Tier 1,0.776,1,A_surface,13,63.22,1,0,,,0,0,,0,"developmental and epileptic encephalopathy, 46",0.7529662497608808
P26678,PLN,Phospholamban,Tier 1,0.775,1,A_surface,7,81.88,0,0,,,1,9,"39536855,32382487,30777430,25240642,21848510,19158349",0,hypertrophic cardiomyopathy,0.750557685745381
P48167,GLRB,Glycine receptor subunit beta,Tier 1,0.775,1,A_surface,12,78.06,1,0,,,0,0,,0,hyperekplexia 2,0.7488854563756028
P08588,ADRB1,Beta-1 adrenergic receptor,Tier 1,0.775,1,A_surface,7,75.31,1,0,,,0,0,,0,hypertension,0.7498467911536156
Q9HBE5,IL21R,Interleukin-21 receptor,Tier 1,0.775,1,A_surface,6,64.12,0,0,,,1,2,"30800133,29244152",0,Cryptosporidiosis - chronic cholangitis - liver disease,0.7501392499286187