id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q5IJ48,,,Tier 1.5,0.593,1,unknown,1,76.44,0,0,,,0,0,,0,ventriculomegaly-cystic kidney disease,0.8112741813611002
P01185,,,Tier 1.5,0.585,1,unknown,5,79.44,1,0,,,0,0,,0,neurohypophyseal diabetes insipidus,0.7825664629740794
O15297,,,Tier 1.5,0.583,1,unknown,1,67.88,0,0,,,0,0,,0,intellectual developmental disorder with gastrointestinal difficulties and high pain threshold,0.7779617805712467
O60930,,,Tier 1.5,0.574,1,unknown,7,79.56,0,0,,,0,0,,0,"progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",0.74733857283595
O60882,,,Tier 1.5,0.568,1,unknown,1,83.31,0,0,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
O75838,,,Tier 1.5,0.564,1,unknown,1,88.62,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.7117048435819099
Q5SWA1,,,Tier 1.5,0.54,1,unknown,5,49.03,1,0,,,0,0,,0,"microcephaly, short stature, and impaired glucose metabolism 2",0.6334721902580683
O43543,,,Tier 1.5,0.529,1,unknown,16,87.12,1,0,,,0,0,,0,spermatogenic failure 50,0.5955217891975265
P01579,,,Tier 1.5,0.498,1,unknown,8,85.31,0,0,,,0,0,,0,Primary hemophagocytic lymphohistiocytosis,0.49197933519665166
Q6NW34,RMP64,Ribonuclease MRP subunit P64,Tier 1.5,0.485,1,unknown,3,64.0,1,0,,,0,0,,0,anauxetic dysplasia 3,0.44914218451265836
Q32NC0,RMP24,Ribonuclease MRP protein subunit p24,Tier 1.5,0.43,1,unknown,3,74.06,1,0,,,0,0,,0,connective tissue disease,0.2652381012117321
Q9NY61,,,Tier 1.5,0.424,1,unknown,3,64.81,1,0,,,0,0,,0,skin neoplasm,0.24706398094697377
P49842,WHR1,Winged helix repair factor 1,Tier 1.5,0.361,1,unknown,5,87.44,1,0,,,0,0,,0,melanoma,0.036990092138582946
O15232,,,Tier 1.5,0.354,0,unknown,0,79.38,0,0,,,0,0,,0,multiple epiphyseal dysplasia type 5,0.8302929519450023
O95343,,,Tier 1.5,0.35,0,unknown,0,67.88,0,0,,,0,0,,0,holoprosencephaly,0.8181248878625513
A3KN83,,,Tier 1.5,0.255,0,unknown,0,67.31,0,0,,,0,0,,0,neurodegenerative disease,0.49840530754835893
Q3KR37,,,Tier 1.5,0.248,0,unknown,0,67.5,0,0,,,0,0,,0,chronic lymphocytic leukemia,0.47654335621881755
O43439,,,Tier 1.5,0.242,0,unknown,0,63.69,0,0,,,0,0,,0,Abnormality of the skeletal system,0.45637506575193026
Q14147,,,Tier 1.5,0.24,0,unknown,0,80.5,0,0,,,0,0,,0,Neurodevelopmental disorder,0.4499737391856989
Q96LM5,SPMIP2,Protein SPMIP2,Tier 1.5,0.232,0,unknown,0,62.75,0,0,,,0,0,,0,Abnormality of the skeletal system,0.4220350712092463
O94964,MTCL2,Microtubule cross-linking factor 2,Tier 1.5,0.221,0,unknown,0,54.25,0,0,,,0,0,,0,skin cancer,0.38790668759818864
Q53TS8,CATSPERT,Cation channel sperm-associated targeting subunit tau,Tier 1.5,0.22,0,unknown,0,39.66,0,0,,,0,0,,0,male infertility due to globozoospermia,0.3830436487908655
Q6P4F1,POFUT3,GDP-fucose protein O-fucosyltransferase 3,Tier 1.5,0.218,0,unknown,0,87.94,0,0,,,0,0,,0,Abnormality of the skeletal system,0.377894214690425
Q6UWJ1,SLC9D1,Solute carrier family 9 member D1,Tier 1.5,0.209,0,unknown,0,75.94,0,0,,,0,0,,0,Anxiety,0.3453798727200914
Q14802,,,Tier 1.5,0.206,0,unknown,0,68.25,0,0,,,0,0,,0,Hypomyelination neuropathy - arthrogryposis,0.3360486957577248
Q2TAC6,,,Tier 1.5,0.205,0,unknown,0,64.62,0,0,,,0,0,,0,Non-immune hydrops fetalis,0.3326218692162316
Q13491,,,Tier 1.5,0.199,0,unknown,0,82.31,0,0,,,0,0,,0,open-angle glaucoma,0.31489783643542385
Q9HAT0,,,Tier 1.5,0.191,0,unknown,0,85.25,0,0,,,0,0,,0,Vitiligo,0.28500489474800955
O95447,,,Tier 1.5,0.187,0,unknown,0,62.31,0,0,,,0,0,,0,neurodegenerative disease,0.27241083934376026
Q9BSJ5,MTNAP1,Mitochondrial nucleoid-associated protein 1,Tier 1.5,0.186,0,unknown,0,44.44,0,0,,,0,0,,0,exostosis,0.270767386991046
Q494R4,DRC12,Dynein regulatory complex protein 12,Tier 1.5,0.154,0,unknown,0,88.31,0,0,,,0,0,,0,familial lipoprotein lipase deficiency,0.16278033923544344
Q5BKX5,ACTMAP,Actin maturation protease,Tier 1.5,0.142,0,unknown,0,83.19,0,0,,,0,0,,0,inflammatory bowel disease,0.12173405430537636
O75610,LEFTY1,Left-right determination factor 1,Tier 1.5,0.13,0,unknown,0,78.44,0,0,,,0,0,,0,Heterotaxia,0.08277492448692116
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.105,0,unknown,0,72.06,0,0,,,1,1,35311942,0,,
O42043,ERVK-18,Endogenous retrovirus group K member 18 Env polyprotein,Tier 1.5,0.105,0,unknown,0,73.12,0,0,,,0,0,,0,,
Q14943,KIR3DS1,Killer cell immunoglobulin-like receptor 3DS1,Tier 1.5,0.105,0,unknown,0,80.81,0,0,,,0,0,,0,,
Q63ZY6,NSUN5P2,Putative methyltransferase NSUN5C,Tier 1.5,0.105,0,unknown,0,77.12,0,0,,,0,0,,0,,
Q66K80,RUSC1-AS1,Putative uncharacterized protein RUSC1-AS1,Tier 1.5,0.105,0,unknown,0,48.66,0,0,,,0,0,,0,,
Q69383,ERVK-6,Endogenous retrovirus group K member 6 Rec protein,Tier 1.5,0.105,0,unknown,0,76.12,0,0,,,0,0,,0,,
Q6RFH8,DUX4L9,Double homeobox protein 4C,Tier 1.5,0.105,0,unknown,0,62.66,0,0,,,0,0,,0,,
Q9H1B4,NXF5,Nuclear RNA export factor 5,Tier 1.5,0.105,0,unknown,0,76.44,0,0,,,0,0,,0,,
Q9N2K0,,HERV-H_2q24.3 provirus ancestral Env polyprotein,Tier 1.5,0.105,0,unknown,0,65.25,0,0,,,0,0,,0,,
Q6P1J6,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6P1L5,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6P1Q9,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6P4I2,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6P5S7,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6P9F5,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6PF05,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,
Q6PJ21,,,Tier 1.5,0.0,0,unknown,0,,0,0,,,0,0,,0,,