id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P02462,COL4A1,Collagen alpha-1(IV) chain,Tier 1.5,0.854,1,A_assoc,4,48.47,0,0,,,0,0,,1,brain small vessel disease 1 with or without ocular anomalies,0.84655287380359
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,Tier 1.5,0.848,1,A_assoc,7,86.75,1,0,,,0,0,,1,Fish-eye disease,0.8273460309828392
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.847,1,A_assoc,10,90.25,1,0,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.847,1,A_assoc,3,82.94,1,0,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.84,1,A_assoc,3,76.69,1,0,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
P22105,TNXB,Tenascin-X,Tier 1.5,0.837,1,A_assoc,3,87.81,0,0,,,0,0,,1,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.836,1,A_assoc,9,50.62,1,0,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P35858,IGFALS,Insulin-like growth factor-binding protein complex acid labile subunit,Tier 1.5,0.833,1,A_assoc,1,90.56,1,0,,,0,0,,1,Reduced insulin like growth factor binding protein acid labile subunit concentration,0.7760522769257892
P35625,TIMP3,Metalloproteinase inhibitor 3,Tier 1.5,0.831,1,A_assoc,1,87.0,0,0,,,1,3,"42105605,36768220",1,Sorsby fundus dystrophy,0.7684253675298044
P02748,C9,Complement component C9,Tier 1.5,0.829,1,A_assoc,9,78.75,1,0,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
O15230,LAMA5,Laminin subunit alpha-5,Tier 1.5,0.828,1,A_assoc,2,79.12,1,0,,,0,0,,1,"nephrotic syndrome, IIa 26",0.7594872666460903
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.819,1,A_assoc,4,47.25,0,0,,,0,0,,1,porencephaly 2,0.7294975109351518
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.815,1,A_assoc,18,91.38,1,0,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
P36955,SERPINF1,Pigment epithelium-derived factor,Tier 1.5,0.811,1,A_assoc,3,90.12,0,0,,,1,17,"41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805",1,osteogenesis imperfecta,0.701995723393119
O00187,MASP2,Mannan-binding lectin serine protease 2,Tier 1.5,0.81,1,A_assoc,10,89.44,0,0,,,1,1,40371468,1,immunodeficiency due to MASP-2 deficiency,0.6996393077218865
Q9Y6C2,EMILIN1,EMILIN-1,Tier 1.5,0.786,1,A_assoc,2,62.91,0,0,,,0,0,,1,arterial tortuosity-bone fragility syndrome,0.6185329512431467
P49767,VEGFC,Vascular endothelial growth factor C,Tier 1.5,0.785,1,A_assoc,4,73.19,0,0,,,0,0,,1,Milroy disease,0.6170524106764851
Q16270,IGFBP7,Insulin-like growth factor-binding protein 7,Tier 1.5,0.785,1,A_assoc,1,84.44,0,0,,,1,4,"41192243,27679852,41280530",1,familial retinal arterial macroaneurysm,0.6182241349863704
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.775,1,A_assoc,4,75.69,1,0,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
P10451,SPP1,Osteopontin,Tier 1.5,0.772,1,A_assoc,3,53.41,0,0,,,1,62,"41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031",1,osteoporosis,0.5729473764531288
P10646,TFPI,Tissue factor pathway inhibitor,Tier 1.5,0.768,1,A_assoc,9,73.62,1,0,,,1,28,"32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161",1,hemophilia A,0.5591056672248635
P10909,CLU,Clusterin,Tier 1.5,0.766,1,A_assoc,2,77.31,0,0,,,1,5,"42041411,37179603,36980195,35383192,26061649",1,Alzheimer disease,0.5545645077431476
P13497,BMP1,Bone morphogenetic protein 1,Tier 1.5,0.766,1,A_assoc,8,81.44,0,0,,,1,1,39939919,1,osteogenesis imperfecta,0.5547577676549571
O00622,CCN1,CCN family member 1,Tier 1.5,0.765,1,A_assoc,2,73.12,0,0,,,0,0,,1,Abnormality of the skeletal system,0.5505331194769112
P02771,AFP,Alpha-fetoprotein,Tier 1.5,0.765,1,A_assoc,5,88.94,1,0,,,1,195,"41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361",1,Congenital deficiency in alpha-fetoprotein,0.5500580170557311
Q68CZ2,TNS3,Tensin-3,Tier 1.5,0.762,1,A_assoc,1,56.81,0,0,,,0,0,,1,neurodegenerative disease,0.539772721274482
P55145,MANF,Mesencephalic astrocyte-derived neurotrophic factor,Tier 1.5,0.761,1,A_assoc,3,81.69,0,0,,,1,1,12698297,1,"diabetes, deafness, developmental delay, and short stature syndrome",0.5377386885662411
Q9Y3B8,REXO2,"Oligoribonuclease, mitochondrial",Tier 1.5,0.754,1,A_assoc,10,88.19,0,0,,,0,0,,1,neurodegenerative disease,0.5134178677464454
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.753,1,A_assoc,4,90.62,0,0,,,0,0,,1,age-related macular degeneration,0.5100732932209376
Q13177,PAK2,Serine/threonine-protein kinase PAK 2,Tier 1.5,0.736,1,A_assoc,5,74.62,0,0,,,0,0,,1,Knobloch syndrome,0.45371318009439854
Q13625,TP53BP2,Apoptosis-stimulating of p53 protein 2,Tier 1.5,0.735,1,A_assoc,6,58.97,0,0,,,0,0,,1,neurodegenerative disease,0.4484066399496438
Q9UKU9,ANGPTL2,Angiopoietin-related protein 2,Tier 1.5,0.727,1,A_assoc,1,78.19,0,0,,,0,0,,1,Abnormality of the skeletal system,0.4235882639081519
Q96SL4,GPX7,Glutathione peroxidase 7,Tier 1.5,0.721,1,A_assoc,1,92.69,0,0,,,0,0,,1,Abnormality of the skeletal system,0.40349356855524837
Q16627,CCL14,C-C motif chemokine 14,Tier 1.5,0.711,1,A_assoc,2,85.38,0,0,,,0,0,,1,neurodegenerative disease,0.37013422446672883
P24593,IGFBP5,Insulin-like growth factor-binding protein 5,Tier 1.5,0.711,1,A_assoc,3,76.06,1,0,,,1,4,"39317671,31930684",1,hypothyroidism,0.3702458751451027
O43866,CD5L,CD5 antigen-like,Tier 1.5,0.706,1,A_assoc,4,85.88,1,0,,,1,3,"40215752,37100807",1,functional neutrophil defect,0.3529395470693119
P10145,CXCL8,Interleukin-8,Tier 1.5,0.706,1,A_assoc,21,88.06,1,0,,,1,15,"39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312",1,coronary artery disease,0.35357870191996843
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.706,1,A_assoc,4,77.25,0,0,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
P12273,PIP,Prolactin-inducible protein,Tier 1.5,0.701,1,A_assoc,1,89.69,0,0,,,1,7,"41440247,36179084,35726753,35336001,28107930,26297462,21559755",1,neurodegenerative disease,0.3382059336442212
P80162,CXCL6,C-X-C motif chemokine 6,Tier 1.5,0.699,1,A_assoc,2,81.0,1,0,,,1,3,"40008515,36649818,32628701",1,neurodegenerative disease,0.3309117033683961
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.693,1,A_assoc,5,81.12,0,0,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
Q8WUP2,FBLIM1,Filamin-binding LIM protein 1,Tier 1.5,0.687,1,A_assoc,3,66.44,0,0,,,0,0,,1,COVID-19,0.28975781420803737
P19876,CXCL3,C-X-C motif chemokine 3,Tier 1.5,0.679,1,A_assoc,2,81.88,1,0,,,0,0,,1,neurodegenerative disease,0.26311734927710556
P19875,CXCL2,C-X-C motif chemokine 2,Tier 1.5,0.674,1,A_assoc,4,81.62,1,0,,,0,0,,1,neurodegenerative disease,0.24624512698601778
O75594,PGLYRP1,Peptidoglycan recognition protein 1,Tier 1.5,0.649,1,A_assoc,1,91.0,0,0,,,1,2,"35821507,33534888",1,dementia,0.16478389504231422
P02776,PF4,Platelet factor 4,Tier 1.5,0.635,1,A_assoc,10,75.06,0,0,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
Q9NWU2,GID8,Glucose-induced degradation protein 8 homolog,Tier 1.5,0.631,1,A_assoc,1,91.94,1,0,,,0,0,,1,Abnormality of the skeletal system,0.10187555420552867
O95445,APOM,Apolipoprotein M,Tier 1.5,0.631,1,A_assoc,3,89.44,0,0,,,1,10,"38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696",1,type 2 diabetes mellitus,0.10169659060091507
P35556,FBN2,Fibrillin-2,Tier 1.5,0.612,0,A_assoc,0,68.38,0,0,,,0,0,,1,congenital contractural arachnodactyly,0.8556257369085999
P02766,TTR,Transthyretin,Tier 1.5,0.609,0,A_assoc,0,88.0,0,0,,,1,11,"39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452",1,"amyloidosis, hereditary systemic 1",0.846421986844374