id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P06865,,,Tier 1.5,0.759,1,unknown,2,93.44,0,0,,,0,0,,1,Tay-Sachs disease,0.8629597356732491
P04275,,,Tier 1.5,0.749,1,unknown,48,75.5,1,0,,,0,0,,1,Von Willebrand disease,0.8296081124598669
P56589,,,Tier 1.5,0.749,1,unknown,2,88.88,0,0,,,0,0,,1,Zellweger syndrome,0.8285793075049609
P09603,,,Tier 1.5,0.618,1,unknown,8,57.41,0,0,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
O75365,,,Tier 1.5,0.612,1,unknown,4,86.88,0,0,,,0,0,,1,hypertension,0.3732487322932303
P07305,,,Tier 1.5,0.562,1,unknown,16,68.75,1,0,,,0,0,,1,open-angle glaucoma,0.2081722206162343
G2XKQ0,SUMO1P1,Small ubiquitin-related modifier 5,Tier 1.5,0.5,1,unknown,1,79.81,0,0,,,0,0,,1,,
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.5,1,unknown,2,88.38,0,0,,,0,0,,1,,
O95352,,,Tier 1.5,0.484,0,unknown,0,87.62,0,0,,,0,0,,1,"spinocerebellar ataxia, autosomal recessive 31",0.7618016657355056
Q5TAT6,,,Tier 1.5,0.481,0,unknown,0,55.59,0,0,,,0,0,,1,Congenital myasthenic syndromes,0.7544056165993482
P48509,,,Tier 1.5,0.473,0,unknown,0,88.25,0,0,,,0,0,,1,"epidermolysis bullosa simplex 7, with nephropathy and deafness",0.7253740723597262
P34910,,,Tier 1.5,0.38,0,unknown,0,50.94,0,0,,,0,0,,1,neurofibromatosis type 1,0.4178305579352045
O60941,,,Tier 1.5,0.377,0,unknown,0,75.38,0,0,,,0,0,,1,cutaneous melanoma,0.4068656041128879
Q5I7T1,,,Tier 1.5,0.375,0,unknown,0,93.0,0,0,,,0,0,,1,Abnormality of the skeletal system,0.4010039380812394
Q5SR56,SLC71A2,Solute carrier family 71 member 2,Tier 1.5,0.372,0,unknown,0,76.75,0,0,,,0,0,,1,atrial fibrillation,0.3910715051744718
Q9H8H3,TMT1A,Thiol S-methyltransferase TMT1A,Tier 1.5,0.358,0,unknown,0,96.12,0,0,,,0,0,,1,heart failure,0.3434183182553741
P49326,,,Tier 1.5,0.349,0,unknown,0,94.94,0,0,,,0,0,,1,type 2 diabetes mellitus,0.3139213554354413
O95741,,,Tier 1.5,0.267,0,unknown,0,86.38,0,0,,,0,0,,1,glioblastoma multiforme,0.03986072724380628
Q9BYX7,POTEKP,Putative beta-actin-like protein 3,Tier 1.5,0.255,0,unknown,0,94.81,0,0,,,0,0,,1,,
A6NMY6,ANXA2P2,Putative annexin A2-like protein,Tier 1.5,0.255,0,unknown,0,94.25,0,0,,,0,0,,1,,
Q6P2E9,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6P3W7,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6P9H4,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PD62,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PI48,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PI78,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PL24,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6Q788,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6QNY1,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6RW13,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6S8J3,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6T4R5,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6UN15,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6UW68,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6UWY0,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6UX53,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6UXN9,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6YHK3,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZN30,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZRV2,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZS17,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZSA7,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZU35,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6ZUX7,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q70EL4,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q70UQ0,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q765P7,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q76LX8,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q7L0J3,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q7L0Y3,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,