id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,79.19,1,0,,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,80.75,1,0,,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P13671,C6,Complement component C6,Tier 1,0.795,11,79.62,1,0,,,,1,31,"41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710",1,Immunodeficiency due to a late component of complements deficiency,0.75437296887129
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
P04156,PRNP,Major prion protein,Tier 1,0.785,70,64.19,1,0,,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,83.5,1,0,,,,1,64,"41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087",1,"hearing loss, autosomal recessive",0.5910507391848663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,90.25,1,0,,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,57.66,1,0,,,,1,1,30161145,1,obesity due to pro-opiomelanocortin deficiency,0.6958797353500403
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
P0C0L4,C4A,Complement C4-A,Tier 1,0.74,12,83.44,1,0,,,,1,4,"37566081,36619572,34739903,31019918",1,,
P15144,ANPEP,Aminopeptidase N,Tier 1,0.74,15,93.06,1,0,,,,1,1,33554306,1,cholelithiasis,0.5030146927270738
Q03405,PLAUR,Urokinase plasminogen activator surface receptor,Tier 1,0.738,13,81.44,1,0,,,,1,2,37533140,1,Abdominal Aortic Aneurysm,0.4819526979346149
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
P11215,ITGAM,Integrin alpha-M,Tier 1,0.72,30,86.25,1,0,,,,0,0,,1,systemic lupus erythematosus,0.30502849242596436
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
Q9NV96,TMEM30A,Cell cycle control protein 50A,Tier 1,0.71,33,89.5,1,0,,,,0,0,,1,atrial fibrillation,0.31177132249681394
Q96IY4,CPB2,Carboxypeptidase B2,Tier 1,0.709,10,94.12,0,0,,,,1,4,"37329944,36805075,35861072,30297859",1,type 2 diabetes mellitus,0.19338213943947646
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P13987,CD59,CD59 glycoprotein,Tier 1,0.705,17,79.31,1,0,,,,1,1,19915929,1,primary CD59 deficiency,0.7738276843579196
O60486,PLXNC1,Plexin-C1,Tier 1,0.703,4,79.06,1,0,,,,0,0,,1,asthma,0.532656225351722
P25311,AZGP1,Zinc-alpha-2-glycoprotein,Tier 1,0.701,9,92.88,0,0,,,,1,1,41325160,1,neoplasm,0.10887540652591159
Q12884,FAP,Prolyl endopeptidase FAP,Tier 1,0.7,4,95.62,1,0,,,,1,7,"40046817,39710916,39026723,37192373,36838669,36494579,35879297",1,psoriasis,0.40173767366839236
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
P00738,HP,Haptoglobin,Tier 1,0.695,15,84.81,1,0,,,,1,76,"41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903",1,Hypercholesterolemia,0.5684135700226365
P00746,CFD,Complement factor D,Tier 1,0.695,40,91.0,0,0,,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
O95858,TSPAN15,Tetraspanin-15,Tier 1,0.692,3,87.56,1,0,,,,1,1,37047289,1,venous thromboembolism,0.5182425801223098
P00451,F8,Coagulation factor VIII,Tier 1,0.691,25,60.75,1,0,,,,1,13,"40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313",1,hemophilia A,0.9108044347811838
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q8NBJ9,,,Tier 1,0.688,7,80.25,1,0,,,,0,0,,1,hypothyroidism,0.32686531914177924
O95399,UTS2,Urotensin-2,Tier 1,0.685,2,58.44,0,0,,,,0,0,,1,hair color,0.35316475479030335
P01008,SERPINC1,Antithrombin-III,Tier 1,0.685,27,84.69,0,0,,,,1,11,"32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984",1,hereditary antithrombin deficiency,0.8494671886642873
P03950,ANG,Angiogenin,Tier 1,0.685,56,89.81,0,0,,,,1,99,"41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572",1,amyotrophic lateral sclerosis,0.7865457274017922
P22303,ACHE,Acetylcholinesterase,Tier 1,0.685,78,92.94,0,0,,,,1,135,"41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840",1,Alzheimer disease,0.628678841772617