id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12263,,,Tier 1,0.9,7,63.59,1,0,,,,0,0,,0,,
Q12879,GRIN2A,"Glutamate receptor ionotropic, NMDA 2A",Tier 1,0.88,37,60.84,1,0,,,,0,0,,0,Landau-Kleffner syndrome,0.8407159711916629
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,88.12,0,0,,,,0,0,,0,neurodegenerative disease,0.33211724272317855
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,79.19,1,0,,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q5T848,GPR158,Metabotropic glycine receptor,Tier 1,0.839,6,58.03,1,0,,,,0,0,,0,diverticular disease,0.4384404783771627
Q31135,H2-Ab1,,Tier 1,0.83,12,85.12,0,0,,,,0,0,,0,,
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.83,5,90.12,1,0,,,,0,0,,0,,
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,80.75,1,0,,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
Q9NS82,SLC7A10,Asc-type amino acid transporter 1,Tier 1,0.803,4,83.38,1,0,,,,0,0,,0,asthma,0.5295411410172121
O60895,RAMP2,Receptor activity-modifying protein 2,Tier 1,0.802,10,80.94,1,0,,,,0,0,,0,diabetes mellitus,0.4219370007650345
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P13671,C6,Complement component C6,Tier 1,0.795,11,79.62,1,0,,,,1,31,"41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710",1,Immunodeficiency due to a late component of complements deficiency,0.75437296887129
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
P01909,HLA-DQA1,"HLA class II histocompatibility antigen, DQ alpha 1 chain",Tier 1,0.792,27,87.94,1,0,,,,0,0,,0,Pleural Mesothelioma,0.1228600330569846
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P04156,PRNP,Major prion protein,Tier 1,0.785,70,64.19,1,0,,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
Q13639,,,Tier 1,0.781,3,80.88,1,0,,,,0,0,,0,schizophrenia,0.6060830827022777
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,83.5,1,0,,,,1,64,"41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087",1,"hearing loss, autosomal recessive",0.5910507391848663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,90.25,1,0,,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
O15393,,,Tier 1,0.775,31,79.38,1,0,,,,0,0,,0,COVID-19,0.6157541390484623
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,87.38,0,0,,,,0,0,,0,placental retention,0.23306495563589497
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,85.25,0,0,,,,0,0,,0,,
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.769,20,91.12,1,0,,,,0,0,,0,psoriasis,0.7914863943708039
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
P98073,,,Tier 1,0.761,14,81.5,1,0,,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,57.66,1,0,,,,1,1,30161145,1,obesity due to pro-opiomelanocortin deficiency,0.6958797353500403
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
O75762,TRPA1,Transient receptor potential cation channel subfamily A member 1,Tier 1,0.76,17,81.94,1,0,,,,0,0,,0,familial episodic pain syndrome with predominantly upper body involvement,0.6615353934604322
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
O43614,,,Tier 1,0.75,11,78.94,1,0,,,,0,0,,0,insomnia,0.5988748728311054
P16471,PRLR,Prolactin receptor,Tier 1,0.747,12,61.03,0,0,,,,0,0,,0,familial hyperprolactinemia,0.5718636087471152
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746