id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,83.69,0,0,,,,0,0,,0,inflammatory bowel disease,0.09896486250497885
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,81.25,1,0,,,,0,0,,0,acromegaly,0.6094707180356006
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,83.25,1,0,,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 59",0.7356789732167734
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,80.81,0,0,,,,0,0,,0,neuronal intranuclear inclusion disease,0.4999829066911242
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,80.69,1,0,,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,88.12,1,0,,,,0,0,,0,migraine disorder,0.6060142180667235
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,78.44,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6993945840545625
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,83.31,1,0,,,,0,0,,0,Heterotaxia,0.7109733260300651
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,88.62,1,0,,,,0,0,,0,device complication,0.27547205131467467
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,47.41,0,0,,,,0,0,,0,Dupuytren Contracture,0.5880367459451578
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,73.88,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 14",0.8165232785825526
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,82.0,0,0,,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,85.0,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,92.44,1,0,,,,0,0,,0,asthma,0.7232344154541454
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,84.38,1,0,,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,80.81,0,0,,,,0,0,,0,prostate carcinoma,0.21737104399686757
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,88.56,0,0,,,,0,0,,0,neoplasm,0.1106047389635713
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 41",0.7772658651722512
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,89.44,1,0,,,,0,0,,0,nephropathic cystinosis,0.841818398377195
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,73.44,0,0,,,,0,0,,0,"heterotaxy, visceral, 12, autosomal",0.6929422132808513
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,67.31,1,0,,,,0,0,,0,atrial fibrillation,0.7126293968222049
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,62.38,0,0,,,,0,0,,0,hypothyroidism,0.33117514363294837
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,74.94,0,0,,,,0,0,,0,Seckel syndrome 9,0.683878095944948
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,63.0,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.3277369133971199
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,88.06,1,0,,,,0,0,,0,type 1 diabetes mellitus,0.09182737097469269
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,90.44,0,0,,,,0,0,,0,Carey-Fineman-Ziter  syndrome,0.7790386256350393
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,75.38,1,0,,,,0,0,,0,schizophrenia,0.6687268941647396