{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 83.69, 0, 0, null, null, null, 0, 0, null, 0, "inflammatory bowel disease", 0.09896486250497885], ["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 81.25, 1, 0, null, null, null, 0, 0, null, 0, "acromegaly", 0.6094707180356006], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 83.25, 1, 0, null, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "neuronal intranuclear inclusion disease", 0.4999829066911242], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 80.69, 1, 0, null, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 88.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6060142180667235], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 78.44, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 83.31, 1, 0, null, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 88.62, 1, 0, null, null, null, 0, 0, null, 0, "device complication", 0.27547205131467467], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 47.41, 0, 0, null, null, null, 0, 0, null, 0, "Dupuytren Contracture", 0.5880367459451578], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535]], "truncated": false, "filtered_table_rows_count": 7198, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets order by priority_score desc limit 51", "params": {}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 3886, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 3309, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1", "selected": false}, {"value": "Positive Control", "label": "Positive Control", "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Positive+Control", "selected": false}, {"value": "Negative Control", "label": "Negative Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Negative+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json", "results": [{"value": 0, "label": 0, "count": 7186, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 11, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json", "results": [{"value": 0, "label": 0, "count": 5725, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 1472, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json", "results": [{"value": 0, "label": 0, "count": 3776, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 3422, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json", "results": [{"value": 0, "label": 0, "count": 5514, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 1683, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "activation_state_pdb_active", "toggle_url": "https://apt-scout.org/scout/v_targets.json?_facet=activation_state_pdb_active"}, {"name": "activation_state_pdb_inactive", "toggle_url": "https://apt-scout.org/scout/v_targets.json?_facet=activation_state_pdb_inactive"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?_next=50", "private": false, "allow_execute_sql": true, "query_ms": 452.61386100173695, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}