{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 0 and has_known_aptamer = 0 sorted by priority_score descending", "rows": [["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 83.69, 0, 0, null, null, null, 0, 0, null, 0, "inflammatory bowel disease", 0.09896486250497885], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "neuronal intranuclear inclusion disease", 0.4999829066911242], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 47.41, 0, 0, null, null, null, 0, 0, null, 0, "Dupuytren Contracture", 0.5880367459451578], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.779, 7, 82.0, 0, 0, null, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P01568", "IFNA21", "Interferon alpha-21", "Tier 1.5", 0.777, 0, 85.0, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3695798546847018], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P29017", "CD1C", "T-cell surface glycoprotein CD1c", "Tier 1.5", 0.77, 10, 88.56, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.1106047389635713], ["Q9BVX2", "TMEM106C", "Transmembrane protein 106C", "Tier 1.5", 0.77, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "prostate carcinoma", 0.21737104399686757], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 83.56, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.4908023126074436], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 90.5, 0, 0, null, null, null, 0, 0, null, 1, "catecholaminergic polymorphic ventricular tachycardia", 0.7718998507471558], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 92.69, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.08093942543094014], ["A0A1B0GTW7", "CIROP", "Ciliated left-right organizer metallopeptidase", "Tier 1.5", 0.764, 0, 73.44, 0, 0, null, null, null, 0, 0, null, 0, "heterotaxy, visceral, 12, autosomal", 0.6929422132808513], ["O15370", "SOX12", "Transcription factor SOX-12", "Tier 1.5", 0.76, 0, 63.0, 0, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.3277369133971199], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.76, 1, 74.94, 0, 0, null, null, null, 0, 0, null, 0, "Seckel syndrome 9", 0.683878095944948], ["Q9BZR8", "BCL2L14", "Apoptosis facilitator Bcl-2-like protein 14", "Tier 1.5", 0.76, 0, 62.38, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.33117514363294837], ["A6NI61", "MYMK", "Protein myomaker", "Tier 1.5", 0.758, 0, 90.44, 0, 0, null, null, null, 0, 0, null, 0, "Carey-Fineman-Ziter  syndrome", 0.7790386256350393], ["Q16585", "SGCB", "Beta-sarcoglycan", "Tier 1.5", 0.75, 0, 76.44, 0, 0, null, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2E", 0.8154766151472349], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P56730", "PRSS12", "Neurotrypsin", "Tier 1.5", 0.746, 0, 77.31, 0, 0, null, null, null, 0, 0, null, 0, "intellectual disability, autosomal recessive 1", 0.6621935416695687], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.745, 8, 79.94, 0, 0, null, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.74, 4, 51.91, 0, 0, null, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["Q14246", "ADGRE1", "Adhesion G protein-coupled receptor E1", "Tier 1.5", 0.74, 0, 76.69, 0, 0, null, null, null, 0, 0, null, 0, "diabetic ketoacidosis", 0.20424823130055986], ["Q8N6D2", "RNF182", "E3 ubiquitin-protein ligase RNF182", "Tier 1.5", 0.74, 0, 70.25, 0, 0, null, null, null, 0, 0, null, 0, "periapical tissue disease", 0.304701328693288], ["Q00LT1", "PRCD", "Photoreceptor disk component PRCD", "Tier 1.5", 0.737, 0, 63.97, 0, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7650522818524582], ["P16389", "KCNA2", "Potassium voltage-gated channel subfamily A member 2", "Tier 1.5", 0.735, 0, 77.38, 0, 0, null, null, null, 0, 0, null, 1, "genetic developmental and epileptic encephalopathy", 0.7513374591580034], ["P98196", "ATP11A", "Phospholipid-transporting ATPase IH", "Tier 1.5", 0.735, 0, 82.94, 0, 0, null, null, null, 0, 0, null, 1, "hearing loss, autosomal dominant 84", 0.5506821963658654], ["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "Tier 1.5", 0.735, 7, 85.62, 0, 0, null, null, null, 0, 0, null, 0, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["Q9ULX7", "CA14", "Carbonic anhydrase 14", "Tier 1.5", 0.734, 2, 90.69, 0, 0, null, null, null, 0, 0, null, 0, "epilepsy", 0.4397024990575866], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.733, 4, 62.66, 0, 0, null, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.732, 9, 88.0, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["P53539", "FOSB", "Protein FosB", "Tier 1.5", 0.73, 12, 59.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.22246010664492422], ["P09603", null, null, "Tier 1.5", 0.729, 8, 57.41, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.728, 5, 64.62, 0, 0, null, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["P22732", "SLC2A5", "Solute carrier family 2, facilitated glucose transporter member 5", "Tier 1.5", 0.728, 0, 90.56, 0, 0, null, null, null, 0, 0, null, 1, "Prolonged QT interval", 0.3326218692162316], ["Q9P2B2", "PTGFRN", "Prostaglandin F2 receptor negative regulator", "Tier 1.5", 0.728, 0, 84.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48052208463481294], ["Q92636", "NSMAF", "Protein FAN", "Tier 1.5", 0.725, 0, 88.31, 0, 0, null, null, null, 0, 0, null, 1, "placental retention", 0.36802220150078147], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["Q15399", "TLR1", "Toll-like receptor 1", "Tier 1.5", 0.72, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5956884825296496], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747]], "truncated": false, "filtered_table_rows_count": 4469, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"has_known_aptamer\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "0"}}, "facet_results": {"tier": {"name": "tier", 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false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0", "results": [{"value": 0, "label": 0, "count": 4469, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0", "results": [{"value": 0, "label": 0, "count": 2528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 1941, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0", "results": [{"value": 0, "label": 0, "count": 4469, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&has_known_aptamer=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 937.8857639967464, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}