{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 0 and in_cev_map = 1 sorted by priority_score descending", "rows": [["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 83.56, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.4908023126074436], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 90.5, 0, 0, null, null, null, 0, 0, null, 1, "catecholaminergic polymorphic ventricular tachycardia", 0.7718998507471558], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 92.69, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.08093942543094014], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.745, 8, 79.94, 0, 0, null, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P16389", "KCNA2", "Potassium voltage-gated channel subfamily A member 2", "Tier 1.5", 0.735, 0, 77.38, 0, 0, null, null, null, 0, 0, null, 1, "genetic developmental and epileptic encephalopathy", 0.7513374591580034], ["P98196", "ATP11A", "Phospholipid-transporting ATPase IH", "Tier 1.5", 0.735, 0, 82.94, 0, 0, null, null, null, 0, 0, null, 1, "hearing loss, autosomal dominant 84", 0.5506821963658654], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.732, 9, 88.0, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["P09603", null, null, "Tier 1.5", 0.729, 8, 57.41, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["P22732", "SLC2A5", "Solute carrier family 2, facilitated glucose transporter member 5", "Tier 1.5", 0.728, 0, 90.56, 0, 0, null, null, null, 0, 0, null, 1, "Prolonged QT interval", 0.3326218692162316], ["Q9P2B2", "PTGFRN", "Prostaglandin F2 receptor negative regulator", "Tier 1.5", 0.728, 0, 84.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48052208463481294], ["Q92636", "NSMAF", "Protein FAN", "Tier 1.5", 0.725, 0, 88.31, 0, 0, null, null, null, 0, 0, null, 1, "placental retention", 0.36802220150078147], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["O95562", "SFT2D2", "Vesicle transport protein SFT2B", "Tier 1.5", 0.71, 0, 78.5, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.38598268164814226], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.71, 0, 87.69, 0, 0, null, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["P79483", "HLA-DRB3", "HLA class II histocompatibility antigen, DR beta 3 chain", "Tier 1.5", 0.71, 2, 88.38, 0, 0, null, null, null, 0, 0, null, 1, null, null], ["Q96IY4", "CPB2", "Carboxypeptidase B2", "Tier 1", 0.709, 10, 94.12, 0, 0, null, null, null, 1, 4, "37329944,36805075,35861072,30297859", 1, "type 2 diabetes mellitus", 0.19338213943947646], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.708, 100, 88.06, 0, 0, null, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613], ["P03905", "MT-ND4", "NADH-ubiquinone oxidoreductase chain 4", "Tier 1.5", 0.705, 0, 93.94, 0, 0, null, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.7517935125709835], ["P25311", "AZGP1", "Zinc-alpha-2-glycoprotein", "Tier 1", 0.701, 9, 92.88, 0, 0, null, null, null, 1, 1, "41325160", 1, "neoplasm", 0.10887540652591159], ["P08473", "MME", "Neprilysin", "Tier 1", 0.699, 16, 96.19, 0, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.695, 40, 91.0, 0, 0, null, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["P01615", "IGKV2D-28", "Immunoglobulin kappa variable 2D-28", "Tier 1.5", 0.695, 0, 91.0, 0, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P19021", "PAM", "Peptidyl-glycine alpha-amidating monooxygenase", "Tier 1.5", 0.695, 0, 71.69, 0, 0, null, null, null, 1, 25, "41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210", 1, "type 2 diabetes mellitus", 0.5754371880839976], ["Q30154", "HLA-DRB5", "HLA class II histocompatibility antigen, DR beta 5 chain", "Tier 1.5", 0.694, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "seasonal allergic rhinitis", 0.19424611770933498], ["Q9Y678", "COPG1", "Coatomer subunit gamma-1", "Tier 1.5", 0.692, 1, 87.88, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4905625531390244], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.691, 4, 90.62, 0, 0, null, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["P10586", "PTPRF", "Receptor-type tyrosine-protein phosphatase F", "Tier 1.5", 0.69, 13, 82.0, 0, 0, null, null, null, 1, 4, "42101929,39087949,36594741", 1, "smoking initiation", 0.4641111755355386], ["Q8IUH8", "SPPL2C", "Signal peptide peptidase-like 2C", "Tier 1.5", 0.69, 0, 67.06, 0, 0, null, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.35379836590273994], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.69, 3, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q14520", "HABP2", "Factor VII-activating protease", "Tier 1.5", 0.686, 0, 77.62, 0, 0, null, null, null, 0, 0, null, 1, "follicular thyroid carcinoma", 0.46213907606907034], ["O00501", "CLDN5", "Claudin-5", "Tier 1.5", 0.685, 0, 83.75, 0, 0, null, null, null, 1, 1, "18951306", 1, "genetic disorder", 0.40861362787778505], ["O95399", "UTS2", "Urotensin-2", "Tier 1", 0.685, 2, 58.44, 0, 0, null, null, null, 0, 0, null, 1, "hair color", 0.35316475479030335]], "truncated": false, "filtered_table_rows_count": 2524, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1297, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 1227, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 2524, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 1941, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 583, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 2524, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 2524, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&in_cev_map=1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 868.5735350009054, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}