{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q96IY4", "CPB2", "Carboxypeptidase B2", "Tier 1", 0.709, 10, 94.12, 0, 0, null, null, null, 1, 4, "37329944,36805075,35861072,30297859", 1, "type 2 diabetes mellitus", 0.19338213943947646], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.708, 100, 88.06, 0, 0, null, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P25311", "AZGP1", "Zinc-alpha-2-glycoprotein", "Tier 1", 0.701, 9, 92.88, 0, 0, null, null, null, 1, 1, "41325160", 1, "neoplasm", 0.10887540652591159], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["P14555", "PLA2G2A", "Phospholipase A2, membrane associated", "Tier 1", 0.7, 17, 91.0, 0, 0, null, null, null, 0, 0, null, 0, "familial colorectal cancer", 0.3326218692162316], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["Q5Y7D3", "HLA-DQB1", null, "Tier 1", 0.7, 6, 85.31, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P08473", "MME", "Neprilysin", "Tier 1", 0.699, 16, 96.19, 0, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["O43570", "CA12", "Carbonic anhydrase 12", "Tier 1", 0.695, 40, 87.81, 0, 0, null, null, null, 0, 0, null, 0, "isolated hyperchlorhidrosis", 0.6794515382695604], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.695, 40, 91.0, 0, 0, null, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q96QV1", "HHIP", "Hedgehog-interacting protein", "Tier 1", 0.692, 11, 79.75, 0, 0, null, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.5195282784554633], ["P04435", "TRBV7-9", "T cell receptor beta variable 7-9", "Tier 1", 0.691, 2, 90.06, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.11454334012562349], ["A0A9P1NJI6", null, null, "Tier 1", 0.69, 6, null, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q02083", "NAAA", "N-acylethanolamine-hydrolyzing acid amidase", "Tier 1", 0.69, 2, 92.25, 0, 0, null, null, null, 0, 0, null, 0, "abscess", 0.2726858643799341], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.69, 100, 46.72, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.69, 3, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.687, 3, 92.44, 0, 0, null, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125]], "truncated": false, "filtered_table_rows_count": 2133, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 2133, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 2133, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1492, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 641, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 1227, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 2133, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 889.0069390035933, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}