{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and has_known_aptamer = 0 sorted by priority_score descending", "rows": [["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 81.25, 1, 0, null, null, null, 0, 0, null, 0, "acromegaly", 0.6094707180356006], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 83.25, 1, 0, null, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 80.69, 1, 0, null, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 88.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6060142180667235], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 78.44, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 83.31, 1, 0, null, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 88.62, 1, 0, null, null, null, 0, 0, null, 0, "device complication", 0.27547205131467467], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.782, 6, 73.88, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["Q13639", null, null, "Tier 1", 0.781, 3, 80.88, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.777, 4, 84.38, 1, 0, null, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.777, 5, 92.44, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.7232344154541454], ["O15393", null, null, "Tier 1", 0.775, 31, 79.38, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 91.12, 1, 0, null, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.768, 7, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.764, 6, 89.44, 1, 0, null, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 91.38, 1, 0, null, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 80.56, 1, 0, null, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["P98073", null, null, "Tier 1", 0.761, 14, 81.5, 1, 0, null, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.761, 8, 67.31, 1, 0, null, null, null, 0, 0, null, 0, "atrial fibrillation", 0.7126293968222049], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 81.94, 1, 0, null, null, null, 0, 0, null, 0, "familial episodic pain syndrome with predominantly upper body involvement", 0.6615353934604322], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, null, 1, 0, null, null, null, 0, 0, null, 1, null, null], ["O15552", "FFAR2", "Free fatty acid receptor 2", "Tier 1.5", 0.759, 11, 88.06, 1, 0, null, null, null, 0, 0, null, 0, "type 1 diabetes mellitus", 0.09182737097469269], ["P35462", "DRD3", "D(3) dopamine receptor", "Tier 1.5", 0.757, 6, 75.38, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6687268941647396], ["P07360", null, null, "Tier 1", 0.755, 15, 89.75, 1, 0, null, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 72.06, 1, 0, null, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["O00591", "GABRP", "Gamma-aminobutyric acid receptor subunit pi", "Tier 1.5", 0.752, 2, 79.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6191855696357259], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 85.0, 1, 0, null, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["P0DMS8", "ADORA3", "Adenosine receptor A3", "Tier 1.5", 0.751, 5, 91.31, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6052134617149065], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.75, 9, 76.75, 1, 0, null, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["O43614", null, null, "Tier 1", 0.75, 11, 78.94, 1, 0, null, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["P46089", "GPR3", "G-protein coupled receptor 3", "Tier 1.5", 0.748, 8, 81.81, 1, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.18488148594282316], ["O15245", "SLC22A1", "Solute carrier family 22 member 1", "Tier 1", 0.744, 16, 84.25, 1, 0, null, null, null, 0, 0, null, 0, "coronary artery disease", 0.5384890077265535], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.744, 24, 58.19, 1, 0, null, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["Q8N158", "GPC2", "Glypican-2", "Tier 1", 0.744, 2, 79.06, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.5409211817593593], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.743, 1, 77.88, 1, 0, null, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178]], "truncated": false, "filtered_table_rows_count": 1254, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"has_known_aptamer\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": 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"has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0", "results": [{"value": 0, "label": 0, "count": 1254, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0", "results": [{"value": 1, "label": 1, "count": 635, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 619, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0", "results": [{"value": 1, "label": 1, "count": 1254, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&has_known_aptamer=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 708.3040220022667, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}