{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and in_cev_map = 1 sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 83.5, 1, 0, null, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 90.25, 1, 0, null, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 91.38, 1, 0, null, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 80.56, 1, 0, null, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 57.66, 1, 0, null, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, null, 1, 0, null, null, null, 0, 0, null, 1, null, null], ["P07360", null, null, "Tier 1", 0.755, 15, 89.75, 1, 0, null, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 72.06, 1, 0, null, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 85.0, 1, 0, null, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.75, 9, 76.75, 1, 0, null, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.743, 1, 77.88, 1, 0, null, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P0C0L4", "C4A", "Complement C4-A", "Tier 1", 0.74, 12, 83.44, 1, 0, null, null, null, 1, 4, "37566081,36619572,34739903,31019918", 1, null, null], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.74, 15, 93.06, 1, 0, null, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.738, 13, 81.44, 1, 0, null, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.72, 3, 76.69, 1, 0, null, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["P11215", "ITGAM", "Integrin alpha-M", "Tier 1", 0.72, 30, 86.25, 1, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.30502849242596436], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.711, 5, 56.41, 1, 0, null, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["Q9NV96", "TMEM30A", "Cell cycle control protein 50A", "Tier 1", 0.71, 33, 89.5, 1, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.31177132249681394], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.705, 17, 79.31, 1, 0, null, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["O60486", "PLXNC1", "Plexin-C1", "Tier 1", 0.703, 4, 79.06, 1, 0, null, null, null, 0, 0, null, 1, "asthma", 0.532656225351722], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.702, 2, 84.69, 1, 0, null, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.7, 3, 82.94, 1, 0, null, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["Q12884", "FAP", "Prolyl endopeptidase FAP", "Tier 1", 0.7, 4, 95.62, 1, 0, null, null, null, 1, 7, "40046817,39710916,39026723,37192373,36838669,36494579,35879297", 1, "psoriasis", 0.40173767366839236], ["P00738", "HP", "Haptoglobin", "Tier 1", 0.695, 15, 84.81, 1, 0, null, null, null, 1, 76, "41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903", 1, "Hypercholesterolemia", 0.5684135700226365], ["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.695, 26, 87.19, 1, 0, null, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["O95858", "TSPAN15", "Tetraspanin-15", "Tier 1", 0.692, 3, 87.56, 1, 0, null, null, null, 1, 1, "37047289", 1, "venous thromboembolism", 0.5182425801223098], ["P00451", "F8", "Coagulation factor VIII", "Tier 1", 0.691, 25, 60.75, 1, 0, null, null, null, 1, 13, "40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313", 1, "hemophilia A", 0.9108044347811838], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.69, 3, 91.56, 1, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q6NT16", "SLC18B1", "MFS-type transporter SLC18B1", "Tier 1.5", 0.688, 4, 84.62, 1, 0, null, null, null, 0, 0, null, 1, "Parkinson disease", 0.276931649354752], ["Q8NBJ9", null, null, "Tier 1", 0.688, 7, 80.25, 1, 0, null, null, null, 0, 0, null, 1, "hypothyroidism", 0.32686531914177924]], "truncated": false, "filtered_table_rows_count": 886, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 646, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "selected": false}, {"value": "Negative Control", "label": "Negative Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&tier=Negative+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 886, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 635, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 251, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 886, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 886, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&in_cev_map=1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 708.9787020013318, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}