{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "Tier 1", 0.96, 1, "A_surface", 14, 80.62, 1, 0, null, null, 0, 0, null, 1, "adrenoleukodystrophy", 0.8656366512509434], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.956, 1, "A_surface", 7, 79.56, 1, 0, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "Tier 1.5", 0.953, 1, "A_surface", 5, 88.81, 1, 0, null, null, 0, 0, null, 1, "alternating hemiplegia of childhood 2", 0.842328126568451], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "Tier 1.5", 0.953, 1, "A_surface", 16, 67.25, 1, 0, null, null, 0, 0, null, 1, "long QT syndrome 3", 0.8448298602976083], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "Tier 1.5", 0.953, 1, "A_surface", 3, 87.25, 1, 0, null, null, 0, 0, null, 1, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "Tier 1", 0.953, 1, "A_surface", 25, 79.62, 1, 0, null, null, 0, 0, null, 1, "Kufor-Rakeb syndrome", 0.8439049037191295], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "Tier 1", 0.952, 1, "A_surface", 3, 72.44, 1, 0, null, null, 0, 0, null, 1, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.952, 1, "A_surface", 5, 68.81, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "Tier 1", 0.95, 1, "A_surface", 22, 64.31, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8346884735388165], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "Tier 1.5", 0.95, 1, "A_surface", 1, 84.12, 1, 0, null, null, 0, 0, null, 1, "riboflavin transporter deficiency", 0.8333271825486935], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.95, 1, "A_surface", 1, 77.88, 1, 0, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["Q9NRA2", "SLC17A5", "Sialin", "Tier 1", 0.949, 1, "A_surface", 7, 84.12, 1, 0, null, null, 0, 0, null, 1, "free sialic acid storage disease, infantile form", 0.8292382821211967], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.948, 1, "A_surface", 100, 91.31, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.948, 1, "A_surface", 9, 56.72, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.947, 1, "A_surface", 2, 84.69, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Tier 1", 0.947, 1, "A_surface", 15, 85.44, 1, 0, null, null, 0, 0, null, 1, "Darier disease", 0.8223208039299769], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.947, 1, "A_surface", 33, 61.94, 1, 0, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P02730", "SLC4A1", "Band 3 anion transport protein", "Tier 1", 0.946, 1, "A_surface", 54, 82.12, 1, 0, null, null, 0, 0, null, 1, "hereditary spherocytosis type 4", 0.820137113225454], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "Tier 1", 0.943, 1, "A_surface", 8, 94.69, 1, 0, null, null, 0, 0, null, 1, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436], ["P51798", "CLCN7", "H(+)/Cl(-) exchange transporter 7", "Tier 1.5", 0.942, 1, "A_surface", 9, 80.94, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive malignant osteopetrosis", 0.8065499095904218], ["P49810", "PSEN2", "Presenilin-2", "Tier 1", 0.941, 1, "A_surface", 2, 71.81, 1, 0, null, null, 0, 0, null, 1, "early-onset autosomal dominant Alzheimer disease", 0.8047686386596943], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q9H2M9", "RAB3GAP2", "Rab3 GTPase-activating protein non-catalytic subunit", "Tier 1", 0.939, 1, "A_surface", 1, 79.62, 1, 0, null, null, 0, 0, null, 1, "Cataract - intellectual disability - hypogonadism", 0.7977527040203786], ["Q9Y5Y0", "FLVCR1", "Choline/ethanolamine transporter FLVCR1", "Tier 1", 0.938, 1, "A_surface", 8, 77.56, 1, 0, null, null, 0, 0, null, 1, "Posterior column ataxia - retinitis pigmentosa", 0.7932113640677738], ["Q96JI7", "SPG11", "Spatacsin", "Tier 1.5", 0.937, 1, "A_surface", 3, 66.75, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive spastic paraplegia type 11", 0.7886006646085494], ["Q9NW15", "ANO10", "Anoctamin-10", "Tier 1", 0.937, 1, "A_surface", 5, 86.12, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 10", 0.7915327777093032], ["P05023", "ATP1A1", "Sodium/potassium-transporting ATPase subunit alpha-1", "Tier 1.5", 0.936, 1, "A_surface", 10, 88.69, 1, 0, null, null, 0, 0, null, 1, "Charcot-Marie-tooth disease, axonal, type 2DD", 0.7868851290226483], ["Q6PJF5", "RHBDF2", "Inactive rhomboid protein 2", "Tier 1", 0.936, 1, "A_surface", 5, 67.38, 1, 0, null, null, 0, 0, null, 1, "palmoplantar keratoderma-esophageal carcinoma syndrome", 0.7882817956366938], ["Q8TD43", "TRPM4", "Transient receptor potential cation channel subfamily M member 4", "Tier 1.5", 0.936, 1, "A_surface", 25, 77.44, 1, 0, null, null, 0, 0, null, 1, "Familial progressive cardiac conduction defect", 0.7868180621357534], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["Q9NP58", "ABCB6", "ATP-binding cassette sub-family B member 6", "Tier 1", 0.934, 1, "A_surface", 16, 83.06, 1, 0, null, null, 0, 0, null, 1, "dyschromatosis universalis hereditaria 3", 0.7783407126197405], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["Q8N766", "EMC1", "ER membrane protein complex subunit 1", "Tier 1", 0.931, 1, "A_surface", 10, 87.44, 1, 0, null, null, 0, 0, null, 1, "cerebellar atrophy, visual impairment, and psychomotor retardation;", 0.7687056132401411], ["P78536", "ADAM17", "Disintegrin and metalloproteinase domain-containing protein 17", "Tier 1", 0.929, 1, "A_surface", 33, 72.69, 1, 0, null, null, 0, 0, null, 1, "neonatal inflammatory skin and bowel disease", 0.7624558659108367], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.929, 1, "A_surface", 8, 95.62, 1, 0, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["P00846", "MT-ATP6", "ATP synthase F(0) complex subunit a", "Tier 1.5", 0.928, 1, "A_surface", 10, 88.94, 1, 0, null, null, 0, 0, null, 1, "NARP syndrome", 0.760749518172638], ["Q9BVK8", "TMEM147", "BOS complex subunit TMEM147", "Tier 1", 0.928, 1, "A_surface", 3, 92.5, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly", 0.7615388401822349]], "truncated": false, "filtered_table_rows_count": 440, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 440, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 440, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 321, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 440, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 276, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 164, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 440, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_cryoEM=1&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1069.3103522062302, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}