{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_known_aptamer = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13639", null, null, "Tier 1", 0.781, 3, 80.88, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["O15393", null, null, "Tier 1", 0.775, 31, 79.38, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 91.12, 1, 0, null, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 80.56, 1, 0, null, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["P98073", null, null, "Tier 1", 0.761, 14, 81.5, 1, 0, null, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 81.94, 1, 0, null, null, null, 0, 0, null, 0, "familial episodic pain syndrome with predominantly upper body involvement", 0.6615353934604322], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, null, 1, 0, null, null, null, 0, 0, null, 1, null, null], ["P07360", null, null, "Tier 1", 0.755, 15, 89.75, 1, 0, null, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 85.0, 1, 0, null, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["O43614", null, null, "Tier 1", 0.75, 11, 78.94, 1, 0, null, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["O15245", "SLC22A1", "Solute carrier family 22 member 1", "Tier 1", 0.744, 16, 84.25, 1, 0, null, null, null, 0, 0, null, 0, "coronary artery disease", 0.5384890077265535], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.744, 24, 58.19, 1, 0, null, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["Q8N158", "GPC2", "Glypican-2", "Tier 1", 0.744, 2, 79.06, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.5409211817593593], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.742, 13, 85.06, 1, 0, null, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["D7RIG0", "HLA-DRB1", null, "Tier 1", 0.74, 10, 84.94, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["A0A1B0GX56", "TRDV1", "T cell receptor delta variable 1", "Tier 1", 0.737, 7, 90.69, 1, 0, null, null, null, 0, 0, null, 0, "colorectal carcinoma", 0.07391597093694036], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.734, 11, 57.66, 1, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["P41145", "OPRK1", "Kappa-type opioid receptor", "Tier 1", 0.725, 28, 79.5, 1, 0, null, null, null, 0, 0, null, 0, "alcohol dependence", 0.6106562988740131], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.723, 13, 83.81, 1, 0, null, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["B7Z8K6", "TRDC", "T cell receptor delta constant", "Tier 1", 0.72, 12, 81.38, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["P11215", "ITGAM", "Integrin alpha-M", "Tier 1", 0.72, 30, 86.25, 1, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.30502849242596436], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.72, 24, 86.19, 1, 0, null, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["A0A0B4J271", "TRAV12-3", "T cell receptor alpha variable 12-3", "Tier 1", 0.715, 12, 92.56, 1, 0, null, null, null, 0, 0, null, 0, "ulcerative colitis", 0.003139210371371825], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.715, 19, 90.0, 1, 0, null, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 2337, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 2337, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 2337, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 2337, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 1277, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 1060, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1492, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 845, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 767.0657290000236, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}