{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0 and has_known_aptamer = 1 sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 83.5, 1, 0, null, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 90.25, 1, 0, null, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 57.66, 1, 0, null, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["P0C0L4", "C4A", "Complement C4-A", "Tier 1", 0.74, 12, 83.44, 1, 0, null, null, null, 1, 4, "37566081,36619572,34739903,31019918", 1, null, null], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.74, 15, 93.06, 1, 0, null, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.738, 13, 81.44, 1, 0, null, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138]], "truncated": false, "filtered_table_rows_count": 1463, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_known_aptamer\" = :p1 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 964, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 498, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1.5", "selected": false}, {"value": "Negative Control", "label": "Negative Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Negative+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "results": [{"value": 0, "label": 0, "count": 1463, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "results": [{"value": 1, "label": 1, "count": 1463, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "results": [{"value": 1, "label": 1, "count": 834, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 629, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "results": [{"value": 0, "label": 0, "count": 1037, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 426, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 569.9679829995148, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}