{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, has_known_aptamer = 1 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 83.5, 1, 0, null, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 90.25, 1, 0, null, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 57.66, 1, 0, null, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["P0C0L4", "C4A", "Complement C4-A", "Tier 1", 0.74, 12, 83.44, 1, 0, null, null, null, 1, 4, "37566081,36619572,34739903,31019918", 1, null, null], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.74, 15, 93.06, 1, 0, null, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.738, 13, 81.44, 1, 0, null, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.712, 8, 82.62, 1, 0, null, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["Q96IY4", "CPB2", "Carboxypeptidase B2", "Tier 1", 0.709, 10, 94.12, 0, 0, null, null, null, 1, 4, "37329944,36805075,35861072,30297859", 1, "type 2 diabetes mellitus", 0.19338213943947646], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.705, 17, 79.31, 1, 0, null, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P25311", "AZGP1", "Zinc-alpha-2-glycoprotein", "Tier 1", 0.701, 9, 92.88, 0, 0, null, null, null, 1, 1, "41325160", 1, "neoplasm", 0.10887540652591159], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["Q12884", "FAP", "Prolyl endopeptidase FAP", "Tier 1", 0.7, 4, 95.62, 1, 0, null, null, null, 1, 7, "40046817,39710916,39026723,37192373,36838669,36494579,35879297", 1, "psoriasis", 0.40173767366839236], ["P00738", "HP", "Haptoglobin", "Tier 1", 0.695, 15, 84.81, 1, 0, null, null, null, 1, 76, "41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903", 1, "Hypercholesterolemia", 0.5684135700226365], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.695, 40, 91.0, 0, 0, null, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["P15309", "ACP3", "Prostatic acid phosphatase", "Tier 1", 0.695, 17, 92.25, 1, 0, null, null, null, 1, 3, "41890985,25591398", 0, "prostate cancer", 0.5521391557206573], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["O95858", "TSPAN15", "Tetraspanin-15", "Tier 1", 0.692, 3, 87.56, 1, 0, null, null, null, 1, 1, "37047289", 1, "venous thromboembolism", 0.5182425801223098], ["P00451", "F8", "Coagulation factor VIII", "Tier 1", 0.691, 25, 60.75, 1, 0, null, null, null, 1, 13, "40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313", 1, "hemophilia A", 0.9108044347811838], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["P01008", "SERPINC1", "Antithrombin-III", "Tier 1", 0.685, 27, 84.69, 0, 0, null, null, null, 1, 11, "32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984", 1, "hereditary antithrombin deficiency", 0.8494671886642873], ["P03950", "ANG", "Angiogenin", "Tier 1", 0.685, 56, 89.81, 0, 0, null, null, null, 1, 99, "41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572", 1, "amyotrophic lateral sclerosis", 0.7865457274017922], ["P22303", "ACHE", "Acetylcholinesterase", "Tier 1", 0.685, 78, 92.94, 0, 0, null, null, null, 1, 135, "41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840", 1, "Alzheimer disease", 0.628678841772617], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.685, 34, 83.25, 1, 0, null, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.685, 30, 93.0, 1, 0, null, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174]], "truncated": false, "filtered_table_rows_count": 964, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 964, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 964, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 964, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 596, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 641, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 323, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&has_known_aptamer=1&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 615.043172998412, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}