{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 0 and surface_class = \"A_assoc\" sorted by evidence_priority descending", "rows": [["Q00604", "NDP", "Norrin", "Tier 1.5", 0.707, 1, "A_assoc", 11, 83.56, 1, 0, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P15884", "TCF4", "Transcription factor 4", "Tier 1", 0.705, 1, "A_assoc", 5, 51.12, 0, 0, null, null, 1, 4, "36252203,17909039,41851110,37805109", 0, "Pitt-Hopkins syndrome", 0.8490531860867685], ["Q99972", "MYOC", "Myocilin", "Tier 1", 0.699, 1, "A_assoc", 24, 78.94, 0, 0, null, null, 0, 0, null, 0, "glaucoma 1, open angle, A", 0.8294483747483756], ["Q9NZK5", "ADA2", "Adenosine deaminase 2", "Tier 1", 0.699, 1, "A_assoc", 2, 95.81, 0, 0, null, null, 0, 0, null, 0, "deficiency of adenosine deaminase 2", 0.8291292532404531], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "Tier 1.5", 0.697, 1, "A_assoc", 9, 92.56, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant epilepsy with auditory features", 0.8225657483127345], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.695, 1, "A_assoc", 3, 92.44, 0, 0, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125], ["P20062", "TCN2", "Transcobalamin-2", "Tier 1", 0.694, 1, "A_assoc", 11, 91.5, 0, 0, null, null, 1, 3, "41935727,39493449", 0, "transcobalamin II deficiency", 0.8116989428679681], ["Q96MK3", "FAM20A", "Pseudokinase FAM20A", "Tier 1", 0.693, 1, "A_assoc", 4, 85.25, 0, 0, null, null, 0, 0, null, 0, "amelogenesis imperfecta type 1G", 0.8106031517056754], ["P55000", "SLURP1", "Secreted Ly-6/uPAR-related protein 1", "Tier 1", 0.692, 1, "A_assoc", 2, 84.19, 0, 0, null, null, 0, 0, null, 0, "mal de Meleda", 0.8064330379723671], ["P45452", "MMP13", "Collagenase 3", "Tier 1", 0.691, 1, "A_assoc", 49, 88.62, 0, 0, null, null, 1, 4, "41754778,40893365,38471488,38750696", 0, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.685, 1, "A_assoc", 3, 68.62, 1, 0, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["Q13253", "NOG", "Noggin", "Tier 1.5", 0.685, 1, "A_assoc", 2, 86.06, 0, 0, null, null, 1, 2, "38397086", 0, "proximal symphalangism 1A", 0.7844136456463046], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.684, 1, "A_assoc", 8, 73.25, 0, 0, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["Q96S42", "NODAL", "Nodal homolog", "Tier 1", 0.684, 1, "A_assoc", 1, 75.44, 0, 0, null, null, 1, 3, "38155321,24146916,23918801", 0, "heterotaxy, visceral, 5, autosomal", 0.7788051667024423], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.682, 1, "A_assoc", 5, 87.06, 0, 0, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["P29120", "PCSK1", "Neuroendocrine convertase 1", "Tier 1.5", 0.682, 1, "A_assoc", 3, 82.5, 0, 0, null, null, 0, 0, null, 0, "obesity due to prohormone convertase I deficiency", 0.773875795833803], ["P00797", "REN", "Renin", "Tier 1", 0.68, 1, "A_assoc", 91, 85.44, 0, 0, null, null, 1, 456, "42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843", 0, "familial juvenile hyperuricemic nephropathy type 2", 0.7657976389758877], ["P05019", "IGF1", "Insulin-like growth factor 1", "Tier 1", 0.68, 1, "A_assoc", 32, 59.53, 1, 0, null, null, 1, 23, "38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297", 0, "growth delay due to insulin-like growth factor type 1 deficiency", 0.7650418939376437], ["Q9GZV9", "FGF23", "Fibroblast growth factor 23", "Tier 1", 0.679, 1, "A_assoc", 6, 76.62, 1, 0, null, null, 1, 11, "39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086", 0, "autosomal dominant hypophosphatemic rickets", 0.762326334964193], ["P20849", "COL9A1", "Collagen alpha-1(IX) chain", "Tier 1", 0.678, 1, "A_assoc", 5, 61.5, 0, 0, null, null, 0, 0, null, 0, "Stickler syndrome", 0.7594904923903256], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.677, 1, "A_assoc", 4, 51.91, 0, 0, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["P55789", "GFER", "FAD-linked sulfhydryl oxidase ALR", "Tier 1.5", 0.677, 1, "A_assoc", 7, 76.88, 0, 0, null, null, 0, 0, null, 0, "congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome", 0.7556346526616893], ["Q12794", "HYAL1", "Hyaluronidase-1", "Tier 1.5", 0.672, 1, "A_assoc", 1, 94.0, 0, 0, null, null, 0, 0, null, 0, "Hyaluronidase deficiency", 0.7412407206736383], ["Q92752", "TNR", "Tenascin-R", "Tier 1.5", 0.672, 1, "A_assoc", 2, 78.5, 0, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus", 0.7403484347367364], ["O15520", "FGF10", "Fibroblast growth factor 10", "Tier 1.5", 0.67, 1, "A_assoc", 2, 80.0, 0, 0, null, null, 1, 1, "35415885", 0, "Lacrimoauriculodentodigital syndrome", 0.7344198619465704], ["P35225", "IL13", "Interleukin-13", "Tier 1", 0.669, 1, "A_assoc", 13, 85.62, 1, 0, null, null, 1, 9, "41463156,35356877,33742062,32784904,27640094,29949702,21793788", 0, "atopic eczema", 0.7297489019498119], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["O00300", "TNFRSF11B", "Tumor necrosis factor receptor superfamily member 11B", "Tier 1.5", 0.666, 1, "A_assoc", 1, 86.5, 0, 0, null, null, 1, 1, "15562003", 0, "juvenile Paget disease", 0.7184894548525037], ["P05305", "EDN1", "Endothelin-1", "Tier 1", 0.666, 1, "A_assoc", 17, 65.19, 1, 0, null, null, 1, 2, "40438585,37198662", 0, "auriculocondylar syndrome", 0.7193561828311311], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["Q9BQB4", "SOST", "Sclerostin", "Tier 1", 0.666, 1, "A_assoc", 3, 70.81, 0, 0, null, null, 1, 32, "42031715,41736700,41545413,41276911,41242313,40464222,40429697,34361085,33717084,33334063,21204783,42030934,41450662,41226313,39470582,39007037,38444701,38074899,37481136,35966595,35869074,35646527", 0, "sclerosteosis 1", 0.7184345506579789], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.665, 1, "A_assoc", 3, 88.12, 0, 0, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["P01270", "PTH", "Parathyroid hormone", "Tier 1", 0.664, 1, "A_assoc", 26, 72.12, 1, 0, null, null, 1, 9, "40464222,40108760,39880691,38079395,25901535,41303575,41226313", 0, "hypoparathyroidism, familial isolated 1", 0.7147450451832739], ["P11686", "SFTPC", "Surfactant protein C", "Tier 1.5", 0.663, 1, "A_assoc", 3, 70.06, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7110128683619542], ["O43897", "TLL1", null, "Tier 1.5", 0.662, 1, "A_assoc", 1, 80.31, 0, 0, null, null, 0, 0, null, 0, "atrial heart septal defect", 0.7050140477090344], ["P19835", "CEL", "Bile salt-activated lipase", "Tier 1.5", 0.658, 1, "A_assoc", 7, 82.56, 0, 0, null, null, 1, 2, "39653009,34940276", 0, "MODY", 0.6940743944678538], ["O43323", "DHH", "Desert hedgehog protein", "Tier 1", 0.657, 1, "A_assoc", 5, 84.38, 0, 0, null, null, 1, 1, "18698484", 0, "46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome", 0.6912706692651148], ["P27352", "CBLIF", "Cobalamin binding intrinsic factor", "Tier 1.5", 0.655, 1, "A_assoc", 2, 90.5, 0, 0, null, null, 0, 0, null, 0, "hereditary intrinsic factor deficiency", 0.683930100359911], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.652, 1, "A_assoc", 1, 79.62, 0, 0, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["Q9Y5K2", "KLK4", "Kallikrein-4", "Tier 1", 0.65, 1, "A_assoc", 18, 90.12, 0, 0, null, null, 1, 2, "30114962,35323639", 0, "Hypomaturation amelogenesis imperfecta", 0.6659029046455642], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142], ["O95631", "NTN1", "Netrin-1", "Tier 1.5", 0.648, 1, "A_assoc", 5, 88.5, 1, 0, null, null, 0, 0, null, 0, "mirror movements 4", 0.6611393488240481], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.642, 1, "A_assoc", 5, 86.69, 1, 0, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["Q16552", "IL17A", "Interleukin-17A", "Tier 1", 0.641, 1, "A_assoc", 44, 84.31, 1, 0, null, null, 1, 30, "42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951", 0, "psoriasis", 0.6367521314106471], ["O95390", "GDF11", "Growth/differentiation factor 11", "Tier 1", 0.636, 1, "A_assoc", 5, 73.12, 0, 0, null, null, 1, 7, "40664633,39909827,31638376,23663781,32408813", 0, "vertebral hypersegmentation and orofacial anomalies", 0.6207007733160915], ["P05230", "FGF1", "Fibroblast growth factor 1", "Tier 1", 0.633, 1, "A_assoc", 96, 90.69, 0, 0, null, null, 1, 3, "35415885,33536494,27663888", 0, "cancer", 0.6088477966360052], ["O76093", "FGF18", "Fibroblast growth factor 18", "Tier 1.5", 0.631, 1, "A_assoc", 1, 87.56, 0, 0, null, null, 1, 1, "35415885", 0, "cancer", 0.6028027301556572], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.631, 1, "A_assoc", 1, 81.5, 0, 0, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P09237", "MMP7", "Matrilysin", "Tier 1", 0.631, 1, "A_assoc", 16, 87.81, 0, 0, null, null, 1, 9, "41890985,37022120,36508319,33742062,31844116,30553167,28738067,27836219", 0, "acne", 0.603247809982021]], "truncated": false, "filtered_table_rows_count": 303, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A_assoc"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 204, "toggle_url": 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"https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 303, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 303, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1485.4124588891864, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}