{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 0 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P13569", "CFTR", "Cystic fibrosis transmembrane conductance regulator", "Tier 1", 0.824, 1, "A_surface", 58, 75.62, 1, 0, null, null, 1, 10, "41148207,31029337,30595527,22483890,15657417", 0, "cystic fibrosis", 0.9133535862571094], ["Q14654", "KCNJ11", "ATP-sensitive inward rectifier potassium channel 11", "Tier 1", 0.81, 1, "A_surface", 9, 83.81, 1, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.8651421397012851], ["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "Tier 1.5", 0.809, 1, "A_surface", 4, 80.94, 0, 0, null, null, 0, 0, null, 0, "Pseudoxanthoma elasticum", 0.864631668818611], ["P07949", "RET", "Proto-oncogene tyrosine-protein kinase receptor Ret", "Tier 1", 0.809, 1, "A_surface", 34, 78.81, 1, 0, null, null, 1, 83, "41962371,41744190,41636718,41526122,41406741,41171123,41082837,41060784,41027166,40932619,40815127,40711581,40633058,40602121,40410423,40285964,40252505,40222299,39344894,39288589,39190775,38953438,38876068,38852325,38718747,38604287,38354543,38282384,38237282,37851382,37774402,37757695,37437453,37245460,36952259,36315022,35550937,35420408,34342436,34132907,34016094,33513536,33462661,33119785,33011620,32760976,32527800,32212604,32138930,31897454", 0, "medullary thyroid gland carcinoma", 0.8617460262224842], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.806, 1, "A_surface", 4, 83.25, 1, 0, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "Tier 1", 0.806, 1, "A_surface", 23, 62.75, 1, 0, null, null, 1, 1, "22617876", 0, "Romano-Ward syndrome", 0.8549238933917284], ["P82251", "SLC7A9", "b(0,+)-type amino acid transporter 1", "Tier 1", 0.805, 1, "A_surface", 4, 85.44, 1, 0, null, null, 0, 0, null, 0, "cystinuria", 0.8484952668941285], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.804, 1, "A_surface", 4, 88.75, 1, 0, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.804, 1, "A_surface", 14, 75.5, 1, 0, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["P41180", "CASR", "Extracellular calcium-sensing receptor", "Tier 1", 0.804, 1, "A_surface", 31, 75.69, 1, 0, null, null, 0, 0, null, 0, "familial hypocalciuric hypercalcemia 1", 0.8460848589627423], ["P48029", "SLC6A8", "Sodium- and chloride-dependent creatine transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 6, 84.62, 1, 0, null, null, 0, 0, null, 0, "creatine transporter deficiency", 0.847268393806457], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.804, 1, "A_surface", 19, 90.0, 1, 0, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 5, 83.81, 1, 0, null, null, 0, 0, null, 0, "lysinuric protein intolerance", 0.8450026270275782], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.803, 1, "A_surface", 24, 58.19, 1, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.803, 1, "A_surface", 10, 82.94, 1, 0, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["Q05586", "GRIN1", "Glutamate receptor ionotropic, NMDA 1", "Tier 1", 0.803, 1, "A_surface", 84, 82.88, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant", 0.8446685494288694], ["Q9UQD0", "SCN8A", "Sodium channel protein type 8 subunit alpha", "Tier 1.5", 0.803, 1, "A_surface", 4, 68.38, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 13", 0.8437707419548253], ["P07333", "CSF1R", "Macrophage colony-stimulating factor 1 receptor", "Tier 1", 0.802, 1, "A_surface", 26, 77.81, 0, 0, null, null, 1, 1, "29277631", 0, "leukoencephalopathy, diffuse hereditary, with spheroids 1", 0.8391971566583056], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.801, 1, "A_surface", 8, 83.12, 1, 0, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P78508", "KCNJ10", "ATP-sensitive inward rectifier potassium channel 10", "Tier 1.5", 0.801, 1, "A_surface", 4, 82.44, 1, 0, null, null, 0, 0, null, 0, "EAST syndrome", 0.8357483559927158], ["Q9HBA0", "TRPV4", "Transient receptor potential cation channel subfamily V member 4", "Tier 1", 0.801, 1, "A_surface", 19, 71.62, 1, 0, null, null, 0, 0, null, 0, "metatropic dysplasia", 0.8356240344517467], ["P16473", "TSHR", "Thyrotropin receptor", "Tier 1", 0.8, 1, "A_surface", 9, 74.0, 1, 0, null, null, 1, 6, "41054857,40997970,40588369,38650837", 0, "hypothyroidism due to TSH receptor mutations", 0.8327127196409464], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.8, 1, "A_surface", 16, 84.94, 0, 0, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["Q92736", "RYR2", "Ryanodine receptor 2", "Tier 1", 0.8, 1, "A_surface", 26, null, 1, 0, null, null, 1, 1, "24130701", 0, "catecholaminergic polymorphic ventricular tachycardia 1", 0.8338648743498255], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 1, 84.19, 0, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["Q16281", "CNGA3", "Cyclic nucleotide-gated channel alpha-3", "Tier 1.5", 0.799, 1, "A_surface", 10, 74.44, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8315799021867489], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.797, 1, "A_surface", 4, 84.38, 1, 0, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.797, 1, "A_surface", 13, 80.69, 1, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P23942", "PRPH2", "Peripherin-2", "Tier 1.5", 0.796, 1, "A_surface", 1, 87.0, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.8194208847382956], ["Q8IZF0", "NALCN", "Sodium leak channel NALCN", "Tier 1", 0.796, 1, "A_surface", 5, 76.69, 1, 0, null, null, 0, 0, null, 0, "congenital contractures of the limbs and face, hypotonia, and developmental delay", 0.8198033442161259], ["Q9BZV2", "SLC19A3", "Thiamine transporter 2", "Tier 1.5", 0.796, 1, "A_surface", 19, 81.56, 1, 0, null, null, 0, 0, null, 0, "biotin-responsive basal ganglia disease", 0.8189646480334981], ["P41181", "AQP2", "Aquaporin-2", "Tier 1", 0.795, 1, "A_surface", 7, 91.75, 1, 0, null, null, 0, 0, null, 0, "diabetes insipidus, nephrogenic, autosomal", 0.817870726313342], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "Tier 1", 0.795, 1, "A_surface", 7, 62.0, 1, 0, null, null, 1, 2, "25870409,25558474", 0, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.795, 1, "A_surface", 6, 73.88, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.795, 1, "A_surface", 11, 84.31, 1, 0, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["Q01974", "ROR2", "Tyrosine-protein kinase transmembrane receptor ROR2", "Tier 1", 0.794, 1, "A_surface", 6, 68.31, 0, 0, null, null, 1, 2, "41782379,18673242", 0, "autosomal recessive Robinow syndrome", 0.8145559265435566], ["Q9H222", "ABCG5", "ATP-binding cassette sub-family G member 5", "Tier 1", 0.793, 1, "A_surface", 8, 85.06, 1, 0, null, null, 0, 0, null, 0, "sitosterolemia", 0.810555184820483], ["Q9NQW8", "CNGB3", "Cyclic nucleotide-gated channel beta-3", "Tier 1.5", 0.791, 1, "A_surface", 9, 68.12, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8033348000666748], ["Q9UM73", "ALK", "ALK tyrosine kinase receptor", "Tier 1", 0.791, 1, "A_surface", 79, 68.19, 0, 0, null, null, 1, 6, "40347134,38604287,32218299,29205808,24116381,21281497", 0, "neuroblastoma", 0.8016889264946979], ["Q01718", "MC2R", "Adrenocorticotropic hormone receptor", "Tier 1.5", 0.79, 1, "A_surface", 2, 85.38, 1, 0, null, null, 0, 0, null, 0, "familial glucocorticoid deficiency", 0.8001007686411645], ["Q12866", "MERTK", "Tyrosine-protein kinase Mer", "Tier 1", 0.79, 1, "A_surface", 42, 72.25, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7985580877708576], ["Q4KMG0", "CDON", "Cell adhesion molecule-related/down-regulated by oncogenes", "Tier 1", 0.79, 1, "A_surface", 3, 62.03, 0, 0, null, null, 1, 3, "36333824,24629635,18698484", 0, "holoprosencephaly", 0.800378039564866], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "Tier 1.5", 0.789, 1, "A_surface", 1, 56.72, 0, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.7961763561533409], ["P16871", "IL7R", "Interleukin-7 receptor subunit alpha", "Tier 1", 0.789, 1, "A_surface", 8, 67.44, 0, 0, null, null, 0, 0, null, 0, "immunodeficiency 104", 0.7983119488718231], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.789, 1, "A_surface", 7, 82.0, 0, 0, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["Q9H1D0", "TRPV6", "Transient receptor potential cation channel subfamily V member 6", "Tier 1", 0.789, 1, "A_surface", 24, 80.56, 1, 0, null, null, 0, 0, null, 0, "hyperparathyroidism, transient neonatal", 0.7964821997780153], ["P15509", "CSF2RA", "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "Tier 1", 0.788, 1, "A_surface", 2, 82.0, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7922592394513138], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.788, 1, "A_surface", 11, 57.66, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979]], "truncated": false, "filtered_table_rows_count": 708, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 474, "toggle_url": 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"https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 708, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 708, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 432, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 276, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1235.9173316508532, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}