{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P00439", "PAH", "Phenylalanine-4-hydroxylase", "Tier 1", 0.618, 1, "B_cargo", 20, 88.69, 0, 0, null, null, 1, 11, "39435559,35394406,35081018,34973551,33386219,32587339,31349094,26043089,24749544,23583275,16914451", 0, "phenylketonuria", 0.892702971437507], ["P40337", "VHL", "von Hippel-Lindau disease tumor suppressor", "Tier 1", 0.616, 1, "B_cargo", 100, 84.44, 0, 0, null, null, 1, 5, "39437434,36250201,34549489,23142634,17290195", 0, "von Hippel-Lindau disease", 0.8883247767048489], ["P22304", "IDS", "Iduronate 2-sulfatase", "Tier 1.5", 0.613, 1, "B_cargo", 2, 93.06, 0, 0, null, null, 1, 9, "41791433,41521476,41396069,40394224,37948569,31273548,30529550,28420169,20842131", 0, "mucopolysaccharidosis type 2", 0.8781523206667287], ["Q13315", "ATM", "Serine-protein kinase ATM", "Tier 1", 0.613, 1, "B_cargo", 14, null, 1, 0, null, null, 1, 9, "41867498,39253616,37656667,34733968,28838608,28706912,26176230,17386435,15181173", 0, "ataxia telangiectasia", 0.8759719859489208], ["O00255", "MEN1", "Menin", "Tier 1", 0.61, 1, "B_cargo", 61, 84.44, 0, 0, null, null, 0, 0, null, 0, "multiple endocrine neoplasia type 1", 0.8653255032429027], ["P35670", "ATP7B", "Copper-transporting ATPase 2", "Tier 1", 0.61, 1, "B_cargo", 13, 71.69, 1, 0, null, null, 1, 1, "39737993", 0, "Wilson disease", 0.8657500553466239], ["O43602", "DCX", "Neuronal migration protein doublecortin", "Tier 1", 0.609, 1, "B_cargo", 18, 66.5, 1, 0, null, null, 0, 0, null, 0, "lissencephaly type 1 due to doublecortin gene mutation", 0.864453842605602], ["P35557", "GCK", "Hexokinase-4", "Tier 1", 0.609, 1, "B_cargo", 35, 93.69, 0, 0, null, null, 0, 0, null, 0, "MODY", 0.8633086470947097], ["Q8NCM8", "DYNC2H1", "Cytoplasmic dynein 2 heavy chain 1", "Tier 1.5", 0.608, 1, "B_cargo", 4, 83.44, 1, 0, null, null, 0, 0, null, 0, "asphyxiating thoracic dystrophy 3", 0.8610362911667925], ["O14746", "TERT", "Telomerase reverse transcriptase", "Tier 1", 0.607, 1, "B_cargo", 23, 80.19, 1, 0, null, null, 1, 13, "41104418,40347637,40062394,39513874,39441744,37427434,36005058,35658460,33476148,28004350,24176970,22013508", 0, "dyskeratosis congenita, autosomal dominant 2", 0.8577919827748599], ["P04629", "NTRK1", "High affinity nerve growth factor receptor", "Tier 1", 0.607, 1, "B_cargo", 65, 78.25, 0, 0, null, null, 1, 1, "38604287", 0, "hereditary sensory and autonomic neuropathy type 4", 0.8579248191890114], ["P21549", "AGXT", "Alanine--glyoxylate aminotransferase", "Tier 1", 0.607, 1, "B_cargo", 17, 98.31, 0, 0, null, null, 0, 0, null, 0, "primary hyperoxaluria type 1", 0.8572717660798254], ["P19544", "WT1", "Wilms tumor protein", "Tier 1", 0.606, 1, "B_cargo", 28, 50.78, 0, 0, null, null, 1, 3, "27417971,19123921,11329270", 0, "Denys-Drash syndrome", 0.8525486743466777], ["Q9BZS1", "FOXP3", "Forkhead box protein P3", "Tier 1", 0.606, 1, "B_cargo", 2, 56.72, 0, 0, null, null, 1, 8, "40448637,34457999,32892748,26999456,24460675,22323540,18698484,18319343", 0, "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome", 0.8516802661294931], ["O76039", "CDKL5", "Cyclin-dependent kinase-like 5", "Tier 1.5", 0.605, 1, "B_cargo", 3, 53.12, 0, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 2", 0.8510325653635987], ["P23760", "PAX3", "Paired box protein Pax-3", "Tier 1", 0.605, 1, "B_cargo", 1, 63.94, 0, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 1", 0.8500072027894306], ["P37231", "PPARG", "Peroxisome proliferator-activated receptor gamma", "Tier 1", 0.605, 1, "B_cargo", 100, 76.12, 0, 0, null, null, 1, 3, "37203464,33671292,28206680", 0, "type 2 diabetes mellitus", 0.8486094742593474], ["P54132", "BLM", "RecQ-like DNA helicase BLM", "Tier 1", 0.605, 1, "B_cargo", 15, 60.53, 0, 0, null, null, 1, 9, "40700985,38959435,34973563,33571410,33050386,31563064,30343567,27332117,19146404", 0, "Bloom syndrome", 0.8491084997646711], ["Q3T906", "GNPTAB", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "Tier 1", 0.605, 1, "B_cargo", 5, 71.62, 1, 0, null, null, 0, 0, null, 0, "mucolipidosis type III, alpha/beta", 0.8490445308315259], ["Q9UIF7", "MUTYH", "Adenine DNA glycosylase", "Tier 1.5", 0.605, 1, "B_cargo", 3, 78.94, 0, 0, null, null, 0, 0, null, 0, "familial adenomatous polyposis 2", 0.8483469680730393], ["Q9Y6K1", "DNMT3A", "DNA (cytosine-5)-methyltransferase 3A", "Tier 1", 0.605, 1, "B_cargo", 43, 72.94, 1, 0, null, null, 1, 3, "39079576,31733056,23179556", 0, "acute myeloid leukemia", 0.8505245588442946], ["O15360", "FANCA", "Fanconi anemia group A protein", "Tier 1", 0.604, 1, "B_cargo", 6, 74.88, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group A", 0.8469248580955555], ["P40692", "MLH1", "DNA mismatch repair protein Mlh1", "Tier 1", 0.604, 1, "B_cargo", 7, 77.31, 0, 0, null, null, 0, 0, null, 0, "Lynch syndrome", 0.8472183133029993], ["P54098", "POLG", "DNA polymerase subunit gamma-1", "Tier 1", 0.604, 1, "B_cargo", 36, 78.94, 1, 0, null, null, 0, 0, null, 0, "mitochondrial DNA depletion syndrome 4a", 0.8474167021250057], ["Q92574", "TSC1", "Hamartin", "Tier 1", 0.604, 1, "B_cargo", 5, 62.06, 1, 0, null, null, 1, 1, "18974095", 0, "tuberous sclerosis", 0.8476796313298992], ["Q96RY7", "IFT140", "Intraflagellar transport protein 140 homolog", "Tier 1", 0.604, 1, "B_cargo", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "short-rib thoracic dysplasia 9 with or without polydactyly", 0.8464676938353167], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.603, 1, "B_cargo", 6, 89.44, 1, 0, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["P58012", "FOXL2", "Forkhead box protein L2", "Tier 1.5", 0.603, 1, "B_cargo", 2, 60.12, 0, 0, null, null, 1, 1, "37933840", 0, "blepharophimosis, ptosis, and epicanthus inversus syndrome", 0.841709236718747], ["Q2M1P5", "KIF7", "Kinesin-like protein KIF7", "Tier 1.5", 0.603, 1, "B_cargo", 5, 67.19, 1, 0, null, null, 0, 0, null, 0, "acrocallosal syndrome", 0.8424257475739304], ["Q2NKJ3", "CTC1", "CST complex subunit CTC1", "Tier 1", 0.603, 1, "B_cargo", 7, 77.5, 1, 0, null, null, 0, 0, null, 0, "Coats plus syndrome", 0.8438631461095314], ["Q92793", "CREBBP", "CREB-binding protein", "Tier 1", 0.603, 1, "B_cargo", 100, 52.53, 0, 0, null, null, 1, 1, "39429683", 0, "Rubinstein-Taybi syndrome due to CREBBP mutations", 0.8442311239876018], ["O43435", "TBX1", "T-box transcription factor TBX1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 68.19, 0, 0, null, null, 1, 1, "24797903", 0, "22q11.2 deletion syndrome", 0.8406035626999856], ["P20823", "HNF1A", "Hepatocyte nuclear factor 1-alpha", "Tier 1.5", 0.602, 1, "B_cargo", 6, 56.97, 0, 0, null, null, 1, 4, "15781225,15629461", 0, "MODY", 0.8405262466243777], ["P38398", "BRCA1", "Breast cancer type 1 susceptibility protein", "Tier 1", 0.602, 1, "B_cargo", 33, 41.59, 1, 0, null, null, 1, 13, "40251554,37288783,36858016,32945515,32245065,29737162,28841982,26784987,24734899,23836560,21800393,16825284", 0, "breast cancer", 0.839035109761358], ["P38935", "IGHMBP2", "DNA-binding protein SMUBP-2", "Tier 1.5", 0.602, 1, "B_cargo", 4, 77.38, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive distal spinal muscular atrophy 1", 0.8396147647161344], ["P82279", "CRB1", "Protein crumbs homolog 1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 75.06, 0, 0, null, null, 0, 0, null, 0, "Leber congenital amaurosis 8", 0.8398871782775204], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.602, 1, "B_cargo", 37, 60.84, 1, 0, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["Q9HBG6", "IFT122", "Intraflagellar transport protein 122 homolog", "Tier 1.5", 0.602, 1, "B_cargo", 5, 82.88, 1, 0, null, null, 0, 0, null, 0, "cranioectodermal dysplasia", 0.8402296001002503], ["O60260", "PRKN", "E3 ubiquitin-protein ligase parkin", "Tier 1", 0.601, 1, "B_cargo", 21, 78.06, 0, 0, null, null, 0, 0, null, 0, "Young adult-onset Parkinsonism", 0.8361755700457273], ["P20807", "CAPN3", "Calpain-3", "Tier 1", 0.601, 1, "B_cargo", 5, 78.25, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2A", 0.8360959201056175], ["Q8N159", "NAGS", "N-acetylglutamate synthase, mitochondrial", "Tier 1.5", 0.601, 1, "B_cargo", 1, 79.75, 0, 0, null, null, 0, 0, null, 0, "hyperammonemia due to N-acetylglutamate synthase deficiency", 0.8382373711482316], ["P49715", "CEBPA", "CCAAT/enhancer-binding protein alpha", "Tier 1", 0.6, 1, "B_cargo", 2, 61.69, 0, 0, null, null, 1, 7, "38965606,30909853,31546149,30795863,28639199,26983359", 0, "acute myeloid leukemia", 0.8336701187896877], ["Q02127", "DHODH", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Tier 1", 0.6, 1, "B_cargo", 100, 96.12, 0, 0, null, null, 1, 1, "29626096", 0, "postaxial acrofacial dysostosis", 0.8330628404263816], ["Q13402", "MYO7A", "Unconventional myosin-VIIa", "Tier 1", 0.6, 1, "B_cargo", 1, 77.25, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1B", 0.8326791560829035], ["Q15910", "EZH2", "Histone-lysine N-methyltransferase EZH2", "Tier 1", 0.6, 1, "B_cargo", 38, 76.25, 1, 0, null, null, 1, 8, "41574287,41223251,40931580,39853766,36626902,32884286,30795863,27719642", 0, "Weaver syndrome", 0.8324078192564933], ["Q2TBA0", "KLHL40", "Kelch-like protein 40", "Tier 1.5", 0.6, 1, "B_cargo", 1, 89.44, 0, 0, null, null, 0, 0, null, 0, "nemaline myopathy 8", 0.8348979900805442], ["Q5S007", "LRRK2", "Leucine-rich repeat serine/threonine-protein kinase 2", "Tier 1", 0.6, 1, "B_cargo", 44, 77.5, 1, 0, null, null, 1, 4, "38467937,37586882,37422510,36774388", 0, "Hereditary late-onset Parkinson disease", 0.8349742982582067], ["Q7Z2E3", "APTX", "Aprataxin", "Tier 1", 0.6, 1, "B_cargo", 11, 80.75, 0, 0, null, null, 0, 0, null, 0, "ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia", 0.832110422501825], ["Q9BXW9", "FANCD2", "Fanconi anemia group D2 protein", "Tier 1.5", 0.6, 1, "B_cargo", 13, 76.75, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group D2", 0.8319139646572291], ["Q05066", "SRY", "Sex-determining region Y protein", "Tier 1.5", 0.599, 1, "B_cargo", 10, 67.62, 1, 0, null, null, 1, 1, "40082426", 0, "46,XY sex reversal 1", 0.8290523705747719]], "truncated": false, "filtered_table_rows_count": 2032, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 1192, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=B_cargo&has_structure=1", "selected": false}, {"value": 0, 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Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}