{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 0 and surface_class = \"unknown\" sorted by evidence_priority descending", "rows": [["P08034", null, null, "Tier 1", 0.604, 1, "unknown", 15, 80.25, 1, 0, null, null, 0, 0, null, 0, "Charcot-Marie-Tooth disease X-linked dominant 1", 0.8483281160610058], ["P23415", null, null, "Tier 1", 0.597, 1, "unknown", 9, 84.0, 1, 0, null, null, 0, 0, null, 0, "hereditary hyperekplexia", 0.822516157871453], ["Q5IJ48", null, null, "Tier 1.5", 0.593, 1, "unknown", 1, 76.44, 0, 0, null, null, 0, 0, null, 0, "ventriculomegaly-cystic kidney disease", 0.8112741813611002], ["Q13422", null, null, "Tier 1", 0.591, 1, "unknown", 10, 47.75, 1, 0, null, null, 0, 0, null, 0, "pancytopenia due to IKZF1 mutations", 0.8043234687306351], ["Q5JTC6", null, null, "Tier 1", 0.59, 1, "unknown", 3, 48.31, 0, 0, null, null, 0, 0, null, 0, "osteopathia striata with cranial sclerosis", 0.8010289843367673], ["P43146", null, null, "Tier 1", 0.587, 1, "unknown", 9, 68.19, 0, 0, null, null, 0, 0, null, 0, "mirror movements 1", 0.7894844854575112], ["Q8WYB5", null, null, "Tier 1", 0.587, 1, "unknown", 3, 48.97, 0, 0, null, null, 0, 0, null, 0, "genitopatellar syndrome", 0.7887666805196595], ["Q92794", null, null, "Tier 1", 0.587, 1, "unknown", 21, 48.66, 0, 0, null, null, 0, 0, null, 0, "autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome", 0.7908994336990406], ["O60828", null, null, "Tier 1", 0.586, 1, "unknown", 3, 70.56, 0, 0, null, null, 0, 0, null, 0, "Renpenning syndrome", 0.7876227110842514], ["P01185", null, null, "Tier 1.5", 0.585, 1, "unknown", 5, 79.44, 1, 0, null, null, 0, 0, null, 0, "neurohypophyseal diabetes insipidus", 0.7825664629740794], ["O15297", null, null, "Tier 1.5", 0.583, 1, "unknown", 1, 67.88, 0, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with gastrointestinal difficulties and high pain threshold", 0.7779617805712467], ["P48067", "SLC6A9", "Sodium- and chloride-dependent glycine transporter 1", "Tier 1", 0.582, 1, "unknown", 9, 81.12, 1, 0, null, null, 0, 0, null, 0, "atypical glycine encephalopathy", 0.7733051820377859], ["O60930", null, null, "Tier 1.5", 0.574, 1, "unknown", 7, 79.56, 0, 0, null, null, 0, 0, null, 0, "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2", 0.74733857283595], ["Q09013", null, null, "Tier 1", 0.574, 1, "unknown", 2, 77.62, 0, 0, null, null, 0, 0, null, 0, "myotonic dystrophy type 1", 0.7480475113698601], ["Q6IQ55", null, null, "Tier 1", 0.569, 1, "unknown", 6, 48.84, 0, 0, null, null, 0, 0, null, 0, "spinocerebellar ataxia type 11", 0.7308755447203157], ["O60882", null, null, "Tier 1.5", 0.568, 1, "unknown", 1, 83.31, 0, 0, null, null, 0, 0, null, 0, "Hypomaturation amelogenesis imperfecta", 0.7281006394540224], ["P29973", null, null, "Tier 1", 0.566, 1, "unknown", 19, 76.25, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7206608041231198], ["O75838", null, null, "Tier 1.5", 0.564, 1, "unknown", 1, 88.62, 0, 0, null, null, 0, 0, null, 0, "hearing loss, autosomal recessive", 0.7117048435819099], ["P98073", null, null, "Tier 1", 0.563, 1, "unknown", 14, 81.5, 1, 0, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["Q15080", null, null, "Tier 1", 0.548, 1, "unknown", 6, 84.19, 0, 0, null, null, 0, 0, null, 0, "chronic granulomatous disease", 0.6592487859566178], ["Q5SWA1", null, null, "Tier 1.5", 0.54, 1, "unknown", 5, 49.03, 1, 0, null, null, 0, 0, null, 0, "microcephaly, short stature, and impaired glucose metabolism 2", 0.6334721902580683], ["Q9NUW8", null, null, "Tier 1", 0.538, 1, "unknown", 48, 80.62, 0, 0, null, null, 0, 0, null, 0, "spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1", 0.6250066855961889], ["O15393", null, null, "Tier 1", 0.535, 1, "unknown", 31, 79.38, 1, 0, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["P39086", null, null, "Tier 1", 0.532, 1, "unknown", 11, 81.12, 0, 0, null, null, 0, 0, null, 0, "epilepsy", 0.6079292940174927], ["Q13639", null, null, "Tier 1", 0.532, 1, "unknown", 3, 80.88, 1, 0, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["O43614", null, null, "Tier 1", 0.53, 1, "unknown", 11, 78.94, 1, 0, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["O43543", null, null, "Tier 1.5", 0.529, 1, "unknown", 16, 87.12, 1, 0, null, null, 0, 0, null, 0, "spermatogenic failure 50", 0.5955217891975265], ["Q6PCD5", null, null, "Tier 1", 0.525, 1, "unknown", 1, 70.12, 0, 0, null, null, 0, 0, null, 0, "Fanconi anemia, complementation group W", 0.5849156442856244], ["Q496J9", null, null, "Tier 1", 0.521, 1, "unknown", 6, 78.0, 0, 0, null, null, 0, 0, null, 0, "botulism", 0.569067134332723], ["P35568", null, null, "Tier 1", 0.518, 1, "unknown", 8, 49.0, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.5600726776459989], ["P29074", null, null, "Tier 1", 0.511, 1, "unknown", 8, 77.19, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5366583695296713], ["Q9BZC1", null, null, "Tier 1", 0.509, 1, "unknown", 2, 61.47, 0, 0, null, null, 0, 0, null, 0, "major depressive disorder", 0.5312056211019677], ["O75616", "ERAL1", "GTPase Era, mitochondrial", "Tier 1", 0.504, 1, "unknown", 2, 77.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5128349940245936], ["Q15291", null, null, "Tier 1", 0.5, 1, "unknown", 27, 77.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.500512770014237], ["P25025", null, null, "Tier 1", 0.499, 1, "unknown", 18, 79.56, 1, 0, null, null, 0, 0, null, 0, "WHIM syndrome 2", 0.4956521666475962], ["P01579", null, null, "Tier 1.5", 0.498, 1, "unknown", 8, 85.31, 0, 0, null, null, 0, 0, null, 0, "Primary hemophagocytic lymphohistiocytosis", 0.49197933519665166], ["Q96QB1", null, null, "Tier 1", 0.494, 1, "unknown", 7, 55.88, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.4815591361203349], ["Q58F21", null, null, "Tier 1", 0.491, 1, "unknown", 21, 62.44, 0, 0, null, null, 0, 0, null, 0, "male infertility with teratozoospermia due to single gene mutation", 0.46995568999565185], ["Q9UHK0", null, null, "Tier 1", 0.491, 1, "unknown", 1, 55.25, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4706636090264093], ["P06307", null, null, "Tier 1", 0.487, 1, "unknown", 9, 65.12, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.45523854320041374], ["Q6NW34", "RMP64", "Ribonuclease MRP subunit P64", "Tier 1.5", 0.485, 1, "unknown", 3, 64.0, 1, 0, null, null, 0, 0, null, 0, "anauxetic dysplasia 3", 0.44914218451265836], ["Q9UNN5", null, null, "Tier 1", 0.475, 1, "unknown", 16, 77.0, 1, 0, null, null, 0, 0, null, 0, "atrial fibrillation", 0.41761152415302133], ["O15075", null, null, "Tier 1", 0.474, 1, "unknown", 11, 72.19, 0, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.414033055781774], ["P01563", null, null, "Tier 1", 0.468, 1, "unknown", 13, 85.06, 0, 0, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["Q9NVH2", null, null, "Tier 1", 0.465, 1, "unknown", 8, 88.06, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.38183943401611947], ["Q86X95", "CIRSR", "Corepressor of RBPJ and splicing regulator", "Tier 1", 0.463, 1, "unknown", 2, 59.72, 1, 0, null, null, 0, 0, null, 0, "major depressive disorder", 0.3767349972483621], ["Q14416", null, null, "Tier 1", 0.461, 1, "unknown", 31, 85.69, 1, 0, null, null, 0, 0, null, 0, "schizophrenia", 0.36850365898315596], ["P42679", null, null, "Tier 1", 0.459, 1, "unknown", 3, 83.75, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.36332514256792015], ["Q1MX18", null, null, "Tier 1", 0.455, 1, "unknown", 1, 83.12, 0, 0, null, null, 0, 0, null, 0, "diverticular disease", 0.34835781104015423], ["P49765", "VEGFB", "Vascular endothelial growth factor B", "Tier 1", 0.451, 1, "unknown", 4, 73.5, 0, 0, null, null, 1, 2, "27189805", 0, "diabetic macular edema", 0.3361465485773345]], "truncated": false, "filtered_table_rows_count": 560, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "unknown"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 442, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 118, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 443, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 117, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 560, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=unknown", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 553, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": "unknown", "label": "unknown", "count": 560, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 560, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 513, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&surface_class=unknown&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1310.7557869516313, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}