{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 0 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 83.69, 0, 0, null, null, null, 0, 0, null, 0, "inflammatory bowel disease", 0.09896486250497885], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 81.25, 1, 0, null, null, null, 0, 0, null, 0, "acromegaly", 0.6094707180356006], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 83.25, 1, 0, null, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "neuronal intranuclear inclusion disease", 0.4999829066911242], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 80.69, 1, 0, null, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 88.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6060142180667235], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 78.44, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 83.31, 1, 0, null, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 47.41, 0, 0, null, null, null, 0, 0, null, 0, "Dupuytren Contracture", 0.5880367459451578], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 88.62, 1, 0, null, null, null, 0, 0, null, 0, "device complication", 0.27547205131467467], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.782, 6, 73.88, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.779, 7, 82.0, 0, 0, null, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P01568", "IFNA21", "Interferon alpha-21", "Tier 1.5", 0.777, 0, 85.0, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3695798546847018], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.777, 4, 84.38, 1, 0, null, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.777, 5, 92.44, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.7232344154541454], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P29017", "CD1C", "T-cell surface glycoprotein CD1c", "Tier 1.5", 0.77, 10, 88.56, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.1106047389635713], ["Q9BVX2", "TMEM106C", "Transmembrane protein 106C", "Tier 1.5", 0.77, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "prostate carcinoma", 0.21737104399686757], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.768, 7, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["A0A1B0GTW7", "CIROP", "Ciliated left-right organizer metallopeptidase", "Tier 1.5", 0.764, 0, 73.44, 0, 0, null, null, null, 0, 0, null, 0, "heterotaxy, visceral, 12, autosomal", 0.6929422132808513], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.764, 6, 89.44, 1, 0, null, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.761, 8, 67.31, 1, 0, null, null, null, 0, 0, null, 0, "atrial fibrillation", 0.7126293968222049], ["O15370", "SOX12", "Transcription factor SOX-12", "Tier 1.5", 0.76, 0, 63.0, 0, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.3277369133971199], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.76, 1, 74.94, 0, 0, null, null, null, 0, 0, null, 0, "Seckel syndrome 9", 0.683878095944948], ["Q9BZR8", "BCL2L14", "Apoptosis facilitator Bcl-2-like protein 14", "Tier 1.5", 0.76, 0, 62.38, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.33117514363294837], ["O15552", "FFAR2", "Free fatty acid receptor 2", "Tier 1.5", 0.759, 11, 88.06, 1, 0, null, null, null, 0, 0, null, 0, "type 1 diabetes mellitus", 0.09182737097469269], ["A6NI61", "MYMK", "Protein myomaker", "Tier 1.5", 0.758, 0, 90.44, 0, 0, null, null, null, 0, 0, null, 0, "Carey-Fineman-Ziter  syndrome", 0.7790386256350393], ["P35462", "DRD3", "D(3) dopamine receptor", "Tier 1.5", 0.757, 6, 75.38, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6687268941647396], ["O00591", "GABRP", "Gamma-aminobutyric acid receptor subunit pi", "Tier 1.5", 0.752, 2, 79.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6191855696357259], ["P0DMS8", "ADORA3", "Adenosine receptor A3", "Tier 1.5", 0.751, 5, 91.31, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6052134617149065], ["Q16585", "SGCB", "Beta-sarcoglycan", "Tier 1.5", 0.75, 0, 76.44, 0, 0, null, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2E", 0.8154766151472349], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P46089", "GPR3", "G-protein coupled receptor 3", "Tier 1.5", 0.748, 8, 81.81, 1, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.18488148594282316], ["P56730", "PRSS12", "Neurotrypsin", "Tier 1.5", 0.746, 0, 77.31, 0, 0, null, null, null, 0, 0, null, 0, "intellectual disability, autosomal recessive 1", 0.6621935416695687], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.74, 4, 51.91, 0, 0, null, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["Q14246", "ADGRE1", "Adhesion G protein-coupled receptor E1", "Tier 1.5", 0.74, 0, 76.69, 0, 0, null, null, null, 0, 0, null, 0, "diabetic ketoacidosis", 0.20424823130055986], ["Q8N6D2", "RNF182", "E3 ubiquitin-protein ligase RNF182", "Tier 1.5", 0.74, 0, 70.25, 0, 0, null, null, null, 0, 0, null, 0, "periapical tissue disease", 0.304701328693288], ["Q86YT5", "SLC13A5", "Na(+)/citrate cotransporter", "Tier 1.5", 0.739, 4, 86.06, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6853612674939716], ["Q00LT1", "PRCD", "Photoreceptor disk component PRCD", "Tier 1.5", 0.737, 0, 63.97, 0, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7650522818524582], ["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "Tier 1.5", 0.735, 7, 85.62, 0, 0, null, null, null, 0, 0, null, 0, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271], ["Q9ULX7", "CA14", "Carbonic anhydrase 14", "Tier 1.5", 0.734, 2, 90.69, 0, 0, null, null, null, 0, 0, null, 0, "epilepsy", 0.4397024990575866], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.733, 4, 62.66, 0, 0, null, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P53539", "FOSB", "Protein FosB", "Tier 1.5", 0.73, 12, 59.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.22246010664492422], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.728, 5, 64.62, 0, 0, null, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132]], "truncated": false, "filtered_table_rows_count": 2348, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 2348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2087, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=0&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 728.6966199972085, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}