{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, in_cev_map = 1 and surface_class = \"unknown\" sorted by evidence_priority descending", "rows": [["P10721", null, null, "Tier 1", 0.768, 1, "unknown", 52, 78.19, 0, 0, null, null, 0, 0, null, 1, "gastrointestinal stromal tumor", 0.8922566232622926], ["Q07889", null, null, "Tier 1", 0.761, 1, "unknown", 91, 76.38, 0, 0, null, null, 0, 0, null, 1, "Noonan syndrome", 0.8708318719184144], ["P06865", null, null, "Tier 1.5", 0.759, 1, "unknown", 2, 93.44, 0, 0, null, null, 0, 0, null, 1, "Tay-Sachs disease", 0.8629597356732491], ["Q05086", null, null, "Tier 1", 0.753, 1, "unknown", 27, 80.75, 1, 0, null, null, 0, 0, null, 1, "Angelman syndrome", 0.8429347259838658], ["P06400", null, null, "Tier 1", 0.752, 1, "unknown", 19, 76.06, 0, 0, null, null, 0, 0, null, 1, "retinoblastoma", 0.8408754966665243], ["P04275", null, null, "Tier 1.5", 0.749, 1, "unknown", 48, 75.5, 1, 0, null, null, 0, 0, null, 1, "Von Willebrand disease", 0.8296081124598669], ["P56589", null, null, "Tier 1.5", 0.749, 1, "unknown", 2, 88.88, 0, 0, null, null, 0, 0, null, 1, "Zellweger syndrome", 0.8285793075049609], ["P52732", null, null, "Tier 1", 0.747, 1, "unknown", 62, 74.38, 0, 0, null, null, 0, 0, null, 1, "microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability", 0.8220137873148912], ["Q15858", null, null, "Tier 1", 0.747, 1, "unknown", 43, 69.06, 1, 0, null, null, 0, 0, null, 1, "primary erythermalgia", 0.8237835765987434], ["Q04771", null, null, "Tier 1", 0.745, 1, "unknown", 85, 83.12, 0, 0, null, null, 0, 0, null, 1, "fibrodysplasia ossificans progressiva", 0.8164474171712364], ["Q9NP72", null, null, "Tier 1", 0.745, 1, "unknown", 1, 85.56, 0, 0, null, null, 0, 0, null, 1, "Micro syndrome", 0.816071079017092], ["P35222", null, null, "Tier 1", 0.743, 1, "unknown", 50, 81.06, 0, 0, null, null, 0, 0, null, 1, "severe intellectual disability-progressive spastic diplegia syndrome", 0.8101632011131414], ["P02751", null, null, "Tier 1", 0.74, 1, "unknown", 69, 69.62, 0, 0, null, null, 0, 0, null, 1, "spondylometaphyseal dysplasia, 'corner fracture' type", 0.8013288836166759], ["Q92608", null, null, "Tier 1", 0.734, 1, "unknown", 6, 79.81, 1, 0, null, null, 0, 0, null, 1, "DOCK2 deficiency", 0.7814025939223274], ["O43318", null, null, "Tier 1", 0.73, 1, "unknown", 25, 69.0, 0, 0, null, null, 0, 0, null, 1, "frontometaphyseal dysplasia 2", 0.767839253516465], ["P84243", null, null, "Tier 1", 0.719, 1, "unknown", 100, 85.94, 0, 0, null, null, 0, 0, null, 1, "Bryant-Li-Bhoj neurodevelopmental syndrome 2", 0.7290694534626342], ["Q8TD19", null, null, "Tier 1", 0.714, 1, "unknown", 2, 73.94, 0, 0, null, null, 0, 0, null, 1, "NEK9-related lethal skeletal dysplasia", 0.7132294892240114], ["Q9H6S3", null, null, "Tier 1", 0.705, 1, "unknown", 2, 73.06, 0, 0, null, null, 0, 0, null, 1, "hearing loss, autosomal recessive", 0.6818863306678549], ["Q5T5Y3", null, null, "Tier 1", 0.694, 1, "unknown", 4, 54.34, 1, 0, null, null, 0, 0, null, 1, "cortical dysplasia, complex, with other brain malformations 12", 0.6471266259726068], ["P17948", null, null, "Tier 1", 0.685, 1, "unknown", 12, 72.62, 0, 0, null, null, 0, 0, null, 1, "neoplasm", 0.6169964471592176], ["P55210", null, null, "Tier 1", 0.684, 1, "unknown", 47, 81.69, 0, 0, null, null, 0, 0, null, 1, "cataract", 0.6121422420887519], ["P01861", null, null, "Tier 1", 0.676, 1, "unknown", 15, 86.75, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q08945", "SSRP1", "FACT complex subunit SSRP1", "Tier 1", 0.675, 1, "unknown", 11, 74.19, 1, 0, null, null, 1, 1, "39653795", 1, "HIV infection", 0.5844684701481319], ["P27694", null, null, "Tier 1", 0.672, 1, "unknown", 48, 83.81, 0, 0, null, null, 0, 0, null, 1, "pulmonary fibrosis and/or bone marrow failure, telomere-related, 6", 0.5720870296163543], ["Q96PU8", null, null, "Tier 1", 0.668, 1, "unknown", 1, 68.69, 0, 0, null, null, 0, 0, null, 1, "cancer", 0.5616375835401949], ["P45985", null, null, "Tier 1", 0.665, 1, "unknown", 4, 77.0, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5507437937196141], ["P17676", null, null, "Tier 1", 0.661, 1, "unknown", 16, 59.69, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5352429213193124], ["O14618", null, null, "Tier 1", 0.658, 1, "unknown", 7, 87.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5272415940824882], ["P54764", null, null, "Tier 1", 0.656, 1, "unknown", 17, 83.5, 0, 0, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5195314334008982], ["P30419", null, null, "Tier 1", 0.655, 1, "unknown", 52, 83.25, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5174483590720084], ["Q8N1W1", null, null, "Tier 1", 0.654, 1, "unknown", 2, 61.56, 0, 0, null, null, 0, 0, null, 1, "hearing loss", 0.5135177841424435], ["P43487", null, null, "Tier 1", 0.651, 1, "unknown", 4, 83.38, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5030392466541774], ["Q16611", null, null, "Tier 1", 0.639, 1, "unknown", 55, 81.31, 0, 0, null, null, 0, 0, null, 1, "chronic lymphocytic leukemia", 0.46377569349166126], ["Q13432", null, null, "Tier 1", 0.634, 1, "unknown", 9, 77.88, 0, 0, null, null, 0, 0, null, 1, "idiopathic CD4 lymphocytopenia", 0.4456292509980772], ["Q9BXB4", null, null, "Tier 1", 0.633, 1, "unknown", 1, 74.06, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4435303946057042], ["Q14213", null, null, "Tier 1", 0.628, 1, "unknown", 4, 87.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.42776938116451996], ["F8WCM5", null, null, "Tier 1", 0.624, 1, "unknown", 4, 48.81, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4145162522265602], ["P57735", null, null, "Tier 1", 0.621, 1, "unknown", 2, 86.62, 0, 0, null, null, 0, 0, null, 1, "atrial fibrillation", 0.40258191116027553], ["P09603", null, null, "Tier 1.5", 0.618, 1, "unknown", 8, 57.41, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["Q13131", null, null, "Tier 1", 0.614, 1, "unknown", 12, 79.56, 1, 0, null, null, 0, 0, null, 1, "cardiovascular disease", 0.37913864498012223], ["O75365", null, null, "Tier 1.5", 0.612, 1, "unknown", 4, 86.88, 0, 0, null, null, 0, 0, null, 1, "hypertension", 0.3732487322932303], ["P07360", null, null, "Tier 1", 0.611, 1, "unknown", 15, 89.75, 1, 0, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P20339", null, null, "Tier 1", 0.611, 1, "unknown", 14, 84.88, 1, 0, null, null, 0, 0, null, 1, "tuberculosis", 0.3708733841760982], ["Q96HW7", null, null, "Tier 1", 0.599, 1, "unknown", 11, 83.19, 1, 0, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.3316421846062003], ["Q8IYB1", null, null, "Tier 1", 0.598, 1, "unknown", 1, 83.56, 0, 0, null, null, 0, 0, null, 1, "Hashimoto's thyroiditis", 0.32654837821466426], ["Q8NBJ9", null, null, "Tier 1", 0.598, 1, "unknown", 7, 80.25, 1, 0, null, null, 0, 0, null, 1, "hypothyroidism", 0.32686531914177924], ["Q15061", null, null, "Tier 1", 0.593, 1, "unknown", 3, 69.62, 1, 0, null, null, 0, 0, null, 1, "triple-negative breast cancer", 0.31136131887350776], ["Q96Q15", null, null, "Tier 1", 0.593, 1, "unknown", 10, 76.88, 1, 0, null, null, 0, 0, null, 1, "contracture", 0.30952829622581673], ["Q9UMX3", null, null, "Tier 1", 0.592, 1, "unknown", 1, 83.5, 0, 0, null, null, 0, 0, null, 1, "osteoarthritis, knee", 0.3060308474018532], ["Q9Y4K1", null, null, "Tier 1", 0.592, 1, "unknown", 3, 48.94, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.3053444558877832]], "truncated": false, "filtered_table_rows_count": 292, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "unknown"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 233, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 59, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 58, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 292, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=unknown", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": "unknown", "label": "unknown", "count": 292, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": 1, "label": 1, "count": 292, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 274, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&in_cev_map=1&surface_class=unknown&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 893.892880063504, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}