{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 0, surface_class = \"unknown\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P06865", null, null, "Tier 1.5", 0.759, 1, "unknown", 2, 93.44, 0, 0, null, null, 0, 0, null, 1, "Tay-Sachs disease", 0.8629597356732491], ["P04275", null, null, "Tier 1.5", 0.749, 1, "unknown", 48, 75.5, 1, 0, null, null, 0, 0, null, 1, "Von Willebrand disease", 0.8296081124598669], ["P56589", null, null, "Tier 1.5", 0.749, 1, "unknown", 2, 88.88, 0, 0, null, null, 0, 0, null, 1, "Zellweger syndrome", 0.8285793075049609], ["P09603", null, null, "Tier 1.5", 0.618, 1, "unknown", 8, 57.41, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["O75365", null, null, "Tier 1.5", 0.612, 1, "unknown", 4, 86.88, 0, 0, null, null, 0, 0, null, 1, "hypertension", 0.3732487322932303], ["Q5IJ48", null, null, "Tier 1.5", 0.593, 1, "unknown", 1, 76.44, 0, 0, null, null, 0, 0, null, 0, "ventriculomegaly-cystic kidney disease", 0.8112741813611002], ["P01185", null, null, "Tier 1.5", 0.585, 1, "unknown", 5, 79.44, 1, 0, null, null, 0, 0, null, 0, "neurohypophyseal diabetes insipidus", 0.7825664629740794], ["O15297", null, null, "Tier 1.5", 0.583, 1, "unknown", 1, 67.88, 0, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with gastrointestinal difficulties and high pain threshold", 0.7779617805712467], ["O60930", null, null, "Tier 1.5", 0.574, 1, "unknown", 7, 79.56, 0, 0, null, null, 0, 0, null, 0, "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2", 0.74733857283595], ["O60882", null, null, "Tier 1.5", 0.568, 1, "unknown", 1, 83.31, 0, 0, null, null, 0, 0, null, 0, "Hypomaturation amelogenesis imperfecta", 0.7281006394540224], ["O75838", null, null, "Tier 1.5", 0.564, 1, "unknown", 1, 88.62, 0, 0, null, null, 0, 0, null, 0, "hearing loss, autosomal recessive", 0.7117048435819099], ["P07305", null, null, "Tier 1.5", 0.562, 1, "unknown", 16, 68.75, 1, 0, null, null, 0, 0, null, 1, "open-angle glaucoma", 0.2081722206162343], ["Q5SWA1", null, null, "Tier 1.5", 0.54, 1, "unknown", 5, 49.03, 1, 0, null, null, 0, 0, null, 0, "microcephaly, short stature, and impaired glucose metabolism 2", 0.6334721902580683], ["O43543", null, null, "Tier 1.5", 0.529, 1, "unknown", 16, 87.12, 1, 0, null, null, 0, 0, null, 0, "spermatogenic failure 50", 0.5955217891975265], ["G2XKQ0", "SUMO1P1", "Small ubiquitin-related modifier 5", "Tier 1.5", 0.5, 1, "unknown", 1, 79.81, 0, 0, null, null, 0, 0, null, 1, null, null], ["P79483", "HLA-DRB3", "HLA class II histocompatibility antigen, DR beta 3 chain", "Tier 1.5", 0.5, 1, "unknown", 2, 88.38, 0, 0, null, null, 0, 0, null, 1, null, null], ["P01579", null, null, "Tier 1.5", 0.498, 1, "unknown", 8, 85.31, 0, 0, null, null, 0, 0, null, 0, "Primary hemophagocytic lymphohistiocytosis", 0.49197933519665166], ["Q6NW34", "RMP64", "Ribonuclease MRP subunit P64", "Tier 1.5", 0.485, 1, "unknown", 3, 64.0, 1, 0, null, null, 0, 0, null, 0, "anauxetic dysplasia 3", 0.44914218451265836], ["O95352", null, null, "Tier 1.5", 0.484, 0, "unknown", 0, 87.62, 0, 0, null, null, 0, 0, null, 1, "spinocerebellar ataxia, autosomal recessive 31", 0.7618016657355056], ["Q5TAT6", null, null, "Tier 1.5", 0.481, 0, "unknown", 0, 55.59, 0, 0, null, null, 0, 0, null, 1, "Congenital myasthenic syndromes", 0.7544056165993482], ["P48509", null, null, "Tier 1.5", 0.473, 0, "unknown", 0, 88.25, 0, 0, null, null, 0, 0, null, 1, "epidermolysis bullosa simplex 7, with nephropathy and deafness", 0.7253740723597262], ["Q32NC0", "RMP24", "Ribonuclease MRP protein subunit p24", "Tier 1.5", 0.43, 1, "unknown", 3, 74.06, 1, 0, null, null, 0, 0, null, 0, "connective tissue disease", 0.2652381012117321], ["Q9NY61", null, null, "Tier 1.5", 0.424, 1, "unknown", 3, 64.81, 1, 0, null, null, 0, 0, null, 0, "skin neoplasm", 0.24706398094697377], ["P34910", null, null, "Tier 1.5", 0.38, 0, "unknown", 0, 50.94, 0, 0, null, null, 0, 0, null, 1, "neurofibromatosis type 1", 0.4178305579352045], ["O60941", null, null, "Tier 1.5", 0.377, 0, "unknown", 0, 75.38, 0, 0, null, null, 0, 0, null, 1, "cutaneous melanoma", 0.4068656041128879], ["Q5I7T1", null, null, "Tier 1.5", 0.375, 0, "unknown", 0, 93.0, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.4010039380812394], ["Q5SR56", "SLC71A2", "Solute carrier family 71 member 2", "Tier 1.5", 0.372, 0, "unknown", 0, 76.75, 0, 0, null, null, 0, 0, null, 1, "atrial fibrillation", 0.3910715051744718], ["P49842", "WHR1", "Winged helix repair factor 1", "Tier 1.5", 0.361, 1, "unknown", 5, 87.44, 1, 0, null, null, 0, 0, null, 0, "melanoma", 0.036990092138582946], ["Q9H8H3", "TMT1A", "Thiol S-methyltransferase TMT1A", "Tier 1.5", 0.358, 0, "unknown", 0, 96.12, 0, 0, null, null, 0, 0, null, 1, "heart failure", 0.3434183182553741], ["O15232", null, null, "Tier 1.5", 0.354, 0, "unknown", 0, 79.38, 0, 0, null, null, 0, 0, null, 0, "multiple epiphyseal dysplasia type 5", 0.8302929519450023], ["O95343", null, null, "Tier 1.5", 0.35, 0, "unknown", 0, 67.88, 0, 0, null, null, 0, 0, null, 0, "holoprosencephaly", 0.8181248878625513], ["P49326", null, null, "Tier 1.5", 0.349, 0, "unknown", 0, 94.94, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.3139213554354413], ["O95741", null, null, "Tier 1.5", 0.267, 0, "unknown", 0, 86.38, 0, 0, null, null, 0, 0, null, 1, "glioblastoma multiforme", 0.03986072724380628], ["A3KN83", null, null, "Tier 1.5", 0.255, 0, "unknown", 0, 67.31, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.49840530754835893], ["A6NMY6", "ANXA2P2", "Putative annexin A2-like protein", "Tier 1.5", 0.255, 0, "unknown", 0, 94.25, 0, 0, null, null, 0, 0, null, 1, null, null], ["Q9BYX7", "POTEKP", "Putative beta-actin-like protein 3", "Tier 1.5", 0.255, 0, "unknown", 0, 94.81, 0, 0, null, null, 0, 0, null, 1, null, null], ["Q3KR37", null, null, "Tier 1.5", 0.248, 0, "unknown", 0, 67.5, 0, 0, null, null, 0, 0, null, 0, "chronic lymphocytic leukemia", 0.47654335621881755], ["O43439", null, null, "Tier 1.5", 0.242, 0, "unknown", 0, 63.69, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.45637506575193026], ["Q14147", null, null, "Tier 1.5", 0.24, 0, "unknown", 0, 80.5, 0, 0, null, null, 0, 0, null, 0, "Neurodevelopmental disorder", 0.4499737391856989], ["Q96LM5", "SPMIP2", "Protein SPMIP2", "Tier 1.5", 0.232, 0, "unknown", 0, 62.75, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.4220350712092463], ["O94964", "MTCL2", "Microtubule cross-linking factor 2", "Tier 1.5", 0.221, 0, "unknown", 0, 54.25, 0, 0, null, null, 0, 0, null, 0, "skin cancer", 0.38790668759818864], ["Q53TS8", "CATSPERT", "Cation channel sperm-associated targeting subunit tau", "Tier 1.5", 0.22, 0, "unknown", 0, 39.66, 0, 0, null, null, 0, 0, null, 0, "male infertility due to globozoospermia", 0.3830436487908655], ["Q6P4F1", "POFUT3", "GDP-fucose protein O-fucosyltransferase 3", "Tier 1.5", 0.218, 0, "unknown", 0, 87.94, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.377894214690425], ["Q6UWJ1", "SLC9D1", "Solute carrier family 9 member D1", "Tier 1.5", 0.209, 0, "unknown", 0, 75.94, 0, 0, null, null, 0, 0, null, 0, "Anxiety", 0.3453798727200914], ["Q14802", null, null, "Tier 1.5", 0.206, 0, "unknown", 0, 68.25, 0, 0, null, null, 0, 0, null, 0, "Hypomyelination neuropathy - arthrogryposis", 0.3360486957577248], ["Q2TAC6", null, null, "Tier 1.5", 0.205, 0, "unknown", 0, 64.62, 0, 0, null, null, 0, 0, null, 0, "Non-immune hydrops fetalis", 0.3326218692162316], ["Q13491", null, null, "Tier 1.5", 0.199, 0, "unknown", 0, 82.31, 0, 0, null, null, 0, 0, null, 0, "open-angle glaucoma", 0.31489783643542385], ["Q9HAT0", null, null, "Tier 1.5", 0.191, 0, "unknown", 0, 85.25, 0, 0, null, null, 0, 0, null, 0, "Vitiligo", 0.28500489474800955], ["O95447", null, null, "Tier 1.5", 0.187, 0, "unknown", 0, 62.31, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.27241083934376026], ["Q9BSJ5", "MTNAP1", "Mitochondrial nucleoid-associated protein 1", "Tier 1.5", 0.186, 0, "unknown", 0, 44.44, 0, 0, null, null, 0, 0, null, 0, "exostosis", 0.270767386991046]], "truncated": false, "filtered_table_rows_count": 677, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "unknown", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 656, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 21, "toggle_url": 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{"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 676, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5", "results": [{"value": "unknown", "label": "unknown", "count": 677, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 443, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 668, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 9, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=0&surface_class=unknown&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 715.5051599256694, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}