{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_activation_state_pdb_pair = 1, has_cryoEM = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P00519", "ABL1", "Tyrosine-protein kinase ABL1", "Tier 1", 0.0, 85, 63.38, 0, 1, "2GQG", "1OPL", null, 1, 5, "31295447,23836560,22411871,21810089,21653319", 1, "chronic myelogenous leukemia", 0.8219762968845584], ["P01112", "HRAS", "GTPase HRas", "Tier 1", 0.0, 100, 91.94, 0, 1, "5P21", "4Q21", null, 0, 0, null, 1, "Costello syndrome", 0.8839339324666988], ["P01116", "KRAS", "GTPase KRas", "Tier 1", 0.0, 100, 91.5, 0, 1, "6GOD", "6MNX", null, 1, 21, "41132421,40824107,40766128,40148451,39215101,38784467,38784452,38604287,37637206,36229679,35473857,34097885,32871244,32370304,32010971,31583159,28639199,28514850,27936442,20565241,17461759", 1, "Noonan syndrome 3", 0.8263697027313498], ["P12931", "SRC", "Proto-oncogene tyrosine-protein kinase Src", "Tier 1", 0.0, 78, 83.44, 0, 1, "1Y57", "2SRC", null, 1, 19, "40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895", 1, "cancer", 0.6343904000453656], ["P24941", "CDK2", "Cyclin-dependent kinase 2", "Tier 1", 0.0, 100, 88.44, 0, 1, "1QMZ", "1HCK", null, 1, 24, "33981223,26972431,21616931,21059336,20394401,19320493,18495468,18186614,11071782,11106396,9826690,9826689,8606778,11566434", 1, "neurodegenerative disease", 0.37316884263655814], ["P31749", "AKT1", "RAC-alpha serine/threonine-protein kinase", "Tier 1", 0.0, 43, 83.06, 0, 1, "4EJN", "3O96", null, 1, 5, "40487120,33535960,27907160,27663888,24242861", 1, "Proteus syndrome", 0.7595350815691262], ["O14965", "AURKA", "Aurora kinase A", "Tier 1", null, 100, 75.06, 0, 1, "1OL5", "1MUO", null, 1, 2, "39776073", 1, "neurodegenerative disease", 0.520933205943212]], "truncated": false, "filtered_table_rows_count": 7, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_activation_state_pdb_pair\" = :p0 and \"has_cryoEM\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 6, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&has_known_aptamer=1", "selected": false}, {"value": 0, "label": 0, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&has_known_aptamer=0", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_activation_state_pdb_pair=1&has_cryoEM=0&tier=Tier+1&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 12.101999003789388, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}