{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 0 and in_cev_map = 1 sorted by priority_score descending", "rows": [["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 83.56, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.4908023126074436], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 90.5, 0, 0, null, null, null, 0, 0, null, 1, "catecholaminergic polymorphic ventricular tachycardia", 0.7718998507471558], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 92.69, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.08093942543094014], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.745, 8, 79.94, 0, 0, null, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P16389", "KCNA2", "Potassium voltage-gated channel subfamily A member 2", "Tier 1.5", 0.735, 0, 77.38, 0, 0, null, null, null, 0, 0, null, 1, "genetic developmental and epileptic encephalopathy", 0.7513374591580034], ["P98196", "ATP11A", "Phospholipid-transporting ATPase IH", "Tier 1.5", 0.735, 0, 82.94, 0, 0, null, null, null, 0, 0, null, 1, "hearing loss, autosomal dominant 84", 0.5506821963658654], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.732, 9, 88.0, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["P09603", null, null, "Tier 1.5", 0.729, 8, 57.41, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["P22732", "SLC2A5", "Solute carrier family 2, facilitated glucose transporter member 5", "Tier 1.5", 0.728, 0, 90.56, 0, 0, null, null, null, 0, 0, null, 1, "Prolonged QT interval", 0.3326218692162316], ["Q9P2B2", "PTGFRN", "Prostaglandin F2 receptor negative regulator", "Tier 1.5", 0.728, 0, 84.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48052208463481294], ["Q92636", "NSMAF", "Protein FAN", "Tier 1.5", 0.725, 0, 88.31, 0, 0, null, null, null, 0, 0, null, 1, "placental retention", 0.36802220150078147], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["O95562", "SFT2D2", "Vesicle transport protein SFT2B", "Tier 1.5", 0.71, 0, 78.5, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.38598268164814226], ["P79483", "HLA-DRB3", "HLA class II histocompatibility antigen, DR beta 3 chain", "Tier 1.5", 0.71, 2, 88.38, 0, 0, null, null, null, 0, 0, null, 1, null, null], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.708, 100, 88.06, 0, 0, null, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613], ["P03905", "MT-ND4", "NADH-ubiquinone oxidoreductase chain 4", "Tier 1.5", 0.705, 0, 93.94, 0, 0, null, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.7517935125709835], ["P08473", "MME", "Neprilysin", "Tier 1", 0.699, 16, 96.19, 0, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["P01615", "IGKV2D-28", "Immunoglobulin kappa variable 2D-28", "Tier 1.5", 0.695, 0, 91.0, 0, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q30154", "HLA-DRB5", "HLA class II histocompatibility antigen, DR beta 5 chain", "Tier 1.5", 0.694, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "seasonal allergic rhinitis", 0.19424611770933498], ["Q9Y678", "COPG1", "Coatomer subunit gamma-1", "Tier 1.5", 0.692, 1, 87.88, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4905625531390244], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.691, 4, 90.62, 0, 0, null, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.69, 3, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q8IUH8", "SPPL2C", "Signal peptide peptidase-like 2C", "Tier 1.5", 0.69, 0, 67.06, 0, 0, null, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.35379836590273994], ["Q14520", "HABP2", "Factor VII-activating protease", "Tier 1.5", 0.686, 0, 77.62, 0, 0, null, null, null, 0, 0, null, 1, "follicular thyroid carcinoma", 0.46213907606907034], ["O95399", "UTS2", "Urotensin-2", "Tier 1", 0.685, 2, 58.44, 0, 0, null, null, null, 0, 0, null, 1, "hair color", 0.35316475479030335], ["Q96MP8", "KCTD7", "BTB/POZ domain-containing protein KCTD7", "Tier 1.5", 0.685, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "progressive myoclonic epilepsy type 3", 0.8021556079083692], ["Q99584", "S100A13", "Protein S100-A13", "Tier 1", 0.681, 12, 80.81, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41302685279153983], ["Q9HBI1", "PARVB", "Beta-parvin", "Tier 1", 0.68, 3, 81.75, 0, 0, null, null, null, 0, 0, null, 1, "thyroiditis", 0.28021156500366357], ["O94842", "TOX4", "TOX high mobility group box family member 4", "Tier 1.5", 0.68, 1, 54.72, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.43085410155338943], ["Q96DA2", "RAB39B", "Ras-related protein Rab-39B", "Tier 1.5", 0.678, 1, 88.38, 0, 0, null, null, null, 0, 0, null, 1, "early-onset parkinsonism-intellectual disability syndrome", 0.7782306319395635], ["O00602", "FCN1", "Ficolin-1", "Tier 1", 0.675, 7, 84.94, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.351581018821974], ["Q9UI42", "CPA4", "Carboxypeptidase A4", "Tier 1.5", 0.674, 5, 93.69, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.19026118958920038], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.673, 4, 47.25, 0, 0, null, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["P78357", "CNTNAP1", "Contactin-associated protein 1", "Tier 1.5", 0.673, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "Hypomyelination neuropathy - arthrogryposis", 0.8286745612673082], ["Q9UK55", "SERPINA10", "Protein Z-dependent protease inhibitor", "Tier 1", 0.672, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "macular degeneration", 0.3247169581531489], ["P02749", "APOH", "Beta-2-glycoprotein 1", "Tier 1", 0.67, 14, 93.12, 0, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.5456247991985232], ["P06703", "S100A6", "Protein S100-A6", "Tier 1", 0.67, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.10449825238323361], ["P78552", "IL13RA1", "Interleukin-13 receptor subunit alpha-1", "Tier 1", 0.67, 4, 81.56, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48627783096767857], ["Q14C86", "GAPVD1", "GTPase-activating protein and VPS9 domain-containing protein 1", "Tier 1.5", 0.67, 0, 62.19, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.46694942126454214], ["Q92997", "DVL3", "Segment polarity protein dishevelled homolog DVL-3", "Tier 1.5", 0.67, 9, 58.91, 0, 0, null, null, null, 0, 0, null, 1, "autosomal dominant Robinow syndrome", 0.7284158836126389], ["Q9BXX0", "EMILIN2", "EMILIN-2", "Tier 1.5", 0.67, 0, 65.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.3471636502626859], ["Q9NVH1", "DNAJC11", "DnaJ homolog subfamily C member 11", "Tier 1.5", 0.67, 0, 84.75, 0, 0, null, null, null, 0, 0, null, 1, "smoking initiation", 0.2238015008808092], ["Q4L180", "FILIP1L", "Filamin A-interacting protein 1-like", "Tier 1.5", 0.67, 0, 67.56, 0, 0, null, null, null, 0, 0, null, 1, "Umbilical hernia", 0.375022308318664]], "truncated": false, "filtered_table_rows_count": 1942, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 830, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 1941, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 1942, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 1942, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1", "results": [{"value": 0, "label": 0, "count": 1942, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&in_cev_map=1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 717.1592480008258, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}