{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 0 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "Tier 1.5", 0.955, 1, "A_surface", 2, 80.62, 0, 0, null, null, 0, 0, null, 1, "Dent disease type 1", 0.850724240157394], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "Tier 1", 0.951, 1, "A_surface", 17, 72.19, 0, 0, null, null, 0, 0, null, 1, "X-linked non-syndromic intellectual disability", 0.8362533125067105], ["P25189", "MPZ", "Myelin protein P0", "Tier 1.5", 0.951, 1, "A_surface", 2, 81.69, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "Tier 1", 0.95, 1, "A_surface", 23, 82.0, 0, 0, null, null, 0, 0, null, 1, "Capillary malformation - arteriovenous malformation", 0.8317426466005666], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "Tier 1", 0.948, 1, "A_surface", 10, 89.88, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448], ["P13473", "LAMP2", "Lysosome-associated membrane glycoprotein 2", "Tier 1.5", 0.948, 1, "A_surface", 2, 83.19, 0, 0, null, null, 0, 0, null, 1, "Glycogen Storage Disease Type 2b", 0.8273010649608126], ["O94766", "B3GAT3", "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "Tier 1", 0.94, 1, "A_surface", 3, 92.56, 0, 0, null, null, 0, 0, null, 1, "Larsen-like syndrome, B3GAT3 type", 0.7995331164339264], ["Q14118", "DAG1", "Dystroglycan 1", "Tier 1", 0.938, 1, "A_surface", 8, 68.19, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive limb-girdle muscular dystrophy type 2P", 0.7935290060634741], ["Q9UPN3", "MACF1", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5", "Tier 1", 0.938, 1, "A_surface", 3, null, 0, 0, null, null, 0, 0, null, 1, "lissencephaly 9 with complex brainstem malformation", 0.7945569032416216], ["P08473", "MME", "Neprilysin", "Tier 1", 0.937, 1, "A_surface", 16, 96.19, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["P35916", "FLT4", "Vascular endothelial growth factor receptor 3", "Tier 1", 0.937, 1, "A_surface", 2, 72.44, 0, 0, null, null, 0, 0, null, 1, "lymphatic malformation 1", 0.7904355931811005], ["O75880", "SCO1", "Cytochrome c oxidase assembly factor SCO1", "Tier 1", 0.935, 1, "A_surface", 10, 77.75, 0, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 4", 0.7827872588103603], ["O94856", "NFASC", "Neurofascin", "Tier 1.5", 0.933, 1, "A_surface", 2, 76.31, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with central and peripheral motor dysfunction", 0.7782432580663833], ["Q15746", "MYLK", "Myosin light chain kinase, smooth muscle", "Tier 1.5", 0.93, 1, "A_surface", 7, 65.88, 0, 0, null, null, 0, 0, null, 1, "aortic aneurysm, familial thoracic 7", 0.7659842793171938], ["O95714", "HERC2", "E3 ubiquitin-protein ligase HERC2", "Tier 1", 0.925, 1, "A_surface", 15, null, 0, 0, null, null, 0, 0, null, 1, "developmental delay with autism spectrum disorder and gait instability", 0.74952129063985], ["Q02413", "DSG1", "Desmoglein-1", "Tier 1.5", 0.92, 1, "A_surface", 1, 62.06, 0, 0, null, null, 0, 0, null, 1, "severe dermatitis-multiple allergies-metabolic wasting syndrome", 0.7335328506238418], ["Q9Y6N7", "ROBO1", "Roundabout homolog 1", "Tier 1", 0.897, 1, "A_surface", 12, 60.0, 0, 0, null, null, 0, 0, null, 1, "neurooculorenal syndrome", 0.6567040910170603], ["Q13555", "CAMK2G", "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "Tier 1.5", 0.891, 1, "A_surface", 2, 78.38, 0, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder 59", 0.6354497016986491], ["P31431", "SDC4", "Syndecan-4", "Tier 1", 0.885, 1, "A_surface", 5, 63.28, 0, 0, null, null, 0, 0, null, 1, "non-small cell lung carcinoma", 0.6168120240815278], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.879, 1, "A_surface", 8, 79.94, 0, 0, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P20701", "ITGAL", "Integrin alpha-L", "Tier 1", 0.877, 1, "A_surface", 41, 82.62, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.5899795223699872], ["P0DOY3", "IGLC3", "Immunoglobulin lambda constant 3", "Tier 1", 0.876, 1, "A_surface", 4, 96.06, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01859", "IGHG2", "Immunoglobulin heavy constant gamma 2", "Tier 1", 0.876, 1, "A_surface", 5, 87.38, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01857", "IGHG1", "Immunoglobulin heavy constant gamma 1", "Tier 1", 0.876, 1, "A_surface", 100, 86.69, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01597", "IGKV1-39", "Immunoglobulin kappa variable 1-39", "Tier 1.5", 0.876, 1, "A_surface", 2, 90.5, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01764", "IGHV3-23", "Immunoglobulin heavy variable 3-23", "Tier 1.5", 0.876, 1, "A_surface", 6, 91.0, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P23083", "IGHV1-2", "Immunoglobulin heavy variable 1-2", "Tier 1.5", 0.876, 1, "A_surface", 1, 91.75, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01593", "IGKV1D-33", "Immunoglobulin kappa variable 1D-33", "Tier 1.5", 0.876, 1, "A_surface", 6, 90.88, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P06312", "IGKV4-1", "Immunoglobulin kappa variable 4-1", "Tier 1.5", 0.876, 1, "A_surface", 10, 90.62, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q10588", "BST1", "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2", "Tier 1", 0.869, 1, "A_surface", 6, 89.62, 0, 0, null, null, 0, 0, null, 1, "Parkinson disease", 0.5634966060310903], ["Q16513", "PKN2", "Serine/threonine-protein kinase N2", "Tier 1", 0.868, 1, "A_surface", 4, 71.44, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5587297348479079], ["P12318", "FCGR2A", "Low affinity immunoglobulin gamma Fc region receptor II-a", "Tier 1", 0.866, 1, "A_surface", 9, 76.94, 0, 0, null, null, 0, 0, null, 1, "ulcerative colitis", 0.5526669305497712], ["Q96D96", "HVCN1", "Voltage-gated hydrogen channel 1", "Tier 1.5", 0.865, 1, "A_surface", 2, 69.75, 0, 0, null, null, 0, 0, null, 1, "Joubert syndrome", 0.5504227269701596], ["Q12913", "PTPRJ", "Receptor-type tyrosine-protein phosphatase eta", "Tier 1", 0.864, 1, "A_surface", 5, 77.75, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.54699134609967], ["Q9P1W8", "SIRPG", "Signal-regulatory protein gamma", "Tier 1.5", 0.864, 1, "A_surface", 2, 85.5, 0, 0, null, null, 0, 0, null, 1, "type 1 diabetes mellitus", 0.5457344827318543], ["O15155", "BET1", "BET1 homolog", "Tier 1.5", 0.864, 1, "A_surface", 1, 83.06, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5468418315282804], ["P04439", "HLA-A", "HLA class I histocompatibility antigen, A alpha chain", "Tier 1", 0.863, 1, "A_surface", 100, 87.12, 0, 0, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5431777522591615], ["P35052", "GPC1", "Glypican-1", "Tier 1", 0.863, 1, "A_surface", 4, 82.5, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.5430103345490354], ["P29320", "EPHA3", "Ephrin type-A receptor 3", "Tier 1", 0.863, 1, "A_surface", 28, 80.75, 0, 0, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5426301743186921], ["P34741", "SDC2", "Syndecan-2", "Tier 1.5", 0.863, 1, "A_surface", 1, 60.84, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.5422254875204983], ["Q15811", "ITSN1", "Intersectin-1", "Tier 1", 0.859, 1, "A_surface", 11, 72.31, 0, 0, null, null, 0, 0, null, 1, "genetic disorder", 0.5312614627352166], ["O00161", "SNAP23", "Synaptosomal-associated protein 23", "Tier 1.5", 0.859, 1, "A_surface", 2, 82.12, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5288361677964304], ["P54756", "EPHA5", "Ephrin type-A receptor 5", "Tier 1.5", 0.858, 1, "A_surface", 2, 79.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5261379875719714], ["P54762", "EPHB1", "Ephrin type-B receptor 1", "Tier 1", 0.856, 1, "A_surface", 8, 83.62, 0, 0, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5204553830376101], ["Q9HCM2", "PLXNA4", "Plexin-A4", "Tier 1.5", 0.856, 1, "A_surface", 1, 83.06, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.518371001420808], ["P15814", "IGLL1", "Immunoglobulin lambda-like polypeptide 1", "Tier 1.5", 0.85, 1, "A_surface", 3, 75.06, 0, 0, null, null, 0, 0, null, 1, "isolated agammaglobulinemia", 0.4996673834185043], ["P78552", "IL13RA1", "Interleukin-13 receptor subunit alpha-1", "Tier 1", 0.846, 1, "A_surface", 4, 81.56, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48627783096767857], ["P18084", "ITGB5", "Integrin beta-5", "Tier 1.5", 0.846, 1, "A_surface", 3, 82.19, 0, 0, null, null, 0, 0, null, 1, "migraine disorder", 0.48652455084344876], ["P19440", "GGT1", "Glutathione hydrolase 1 proenzyme", "Tier 1", 0.845, 1, "A_surface", 12, 94.81, 0, 0, null, null, 0, 0, null, 1, "alcoholic liver disease", 0.48228227774828414], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.845, 1, "A_surface", 100, 88.06, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613]], "truncated": false, "filtered_table_rows_count": 528, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 306, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 222, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 385, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 143, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 180, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1404.3371379375458, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}