{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P01112", "HRAS", "GTPase HRas", "Tier 1", 0.765, 1, "B_cargo", 100, 91.94, 0, 1, "5P21", "4Q21", 0, 0, null, 1, "Costello syndrome", 0.8839339324666988], ["P15289", "ARSA", "Arylsulfatase A", "Tier 1", 0.763, 1, "B_cargo", 10, 96.12, 0, 0, null, null, 0, 0, null, 1, "metachromatic leukodystrophy", 0.8781786404283894], ["O15305", "PMM2", "Phosphomannomutase 2", "Tier 1", 0.761, 1, "B_cargo", 7, 96.44, 0, 0, null, null, 0, 0, null, 1, "PMM2-congenital disorder of glycosylation", 0.8687293837006977], ["P15848", "ARSB", "Arylsulfatase B", "Tier 1.5", 0.761, 1, "B_cargo", 1, 93.12, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 6", 0.8708405439406184], ["P54802", "NAGLU", "Alpha-N-acetylglucosaminidase", "Tier 1.5", 0.761, 1, "B_cargo", 1, 96.75, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 3B", 0.8688752515463204], ["P49748", "ACADVL", "Very long-chain acyl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.76, 1, "B_cargo", 3, 90.25, 0, 0, null, null, 0, 0, null, 1, "very long chain acyl-CoA dehydrogenase deficiency", 0.8655785842544526], ["Q01968", "OCRL", "Inositol polyphosphate 5-phosphatase OCRL", "Tier 1.5", 0.759, 1, "B_cargo", 5, 82.56, 0, 0, null, null, 0, 0, null, 1, "oculocerebrorenal syndrome", 0.8639646099557533], ["P08559", "PDHA1", "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "Tier 1", 0.758, 1, "B_cargo", 9, 94.5, 0, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E1-alpha deficiency", 0.8590861671403908], ["P36507", "MAP2K2", "Dual specificity mitogen-activated protein kinase kinase 2", "Tier 1", 0.757, 1, "B_cargo", 3, 81.62, 0, 0, null, null, 0, 0, null, 1, "cardiofaciocutaneous syndrome", 0.8571797350022399], ["Q04656", "ATP7A", "Copper-transporting ATPase 1", "Tier 1", 0.757, 1, "B_cargo", 22, 73.38, 0, 0, null, null, 0, 0, null, 1, "Menkes disease", 0.8556218833987248], ["P00966", "ASS1", "Argininosuccinate synthase", "Tier 1", 0.756, 1, "B_cargo", 1, 95.5, 0, 0, null, null, 0, 0, null, 1, "citrullinemia type I", 0.8547319473775126], ["P30613", "PKLR", "Pyruvate kinase PKLR", "Tier 1", 0.756, 1, "B_cargo", 58, 90.69, 0, 0, null, null, 0, 0, null, 1, "pyruvate kinase deficiency of red cells", 0.8545857147634045], ["P30566", "ADSL", "Adenylosuccinate lyase", "Tier 1.5", 0.756, 1, "B_cargo", 4, 96.56, 0, 0, null, null, 0, 0, null, 1, "adenylosuccinate lyase deficiency", 0.8537075354730899], ["P46100", "ATRX", "Transcriptional regulator ATRX", "Tier 1", 0.755, 1, "B_cargo", 12, 51.81, 0, 0, null, null, 0, 0, null, 1, "alpha thalassemia-X-linked intellectual disability syndrome", 0.8486940552679562], ["P35914", "HMGCL", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 4, 92.0, 0, 0, null, null, 0, 0, null, 1, "3-hydroxy-3-methylglutaric aciduria", 0.84972741897364], ["P51648", "ALDH3A2", "Aldehyde dehydrogenase family 3 member A2", "Tier 1.5", 0.755, 1, "B_cargo", 1, 96.62, 0, 0, null, null, 0, 0, null, 1, "Sj\u00f6gren-Larsson syndrome", 0.8498976178886021], ["P50336", "PPOX", "Protoporphyrinogen oxidase", "Tier 1.5", 0.755, 1, "B_cargo", 3, 95.31, 0, 0, null, null, 0, 0, null, 1, "variegate porphyria", 0.8511493920751063], ["P11217", "PYGM", "Glycogen phosphorylase, muscle form", "Tier 1", 0.754, 1, "B_cargo", 1, 94.31, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease V", 0.8482737151867437], ["P51570", "GALK1", "Galactokinase", "Tier 1", 0.753, 1, "B_cargo", 20, 97.19, 0, 0, null, null, 0, 0, null, 1, "galactokinase deficiency", 0.8442002323363244], ["Q9Y223", "GNE", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Tier 1", 0.753, 1, "B_cargo", 5, 93.12, 0, 0, null, null, 0, 0, null, 1, "GNE myopathy", 0.8438241196803116], ["P51649", "ALDH5A1", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 5, 91.88, 0, 0, null, null, 0, 0, null, 1, "succinic semialdehyde dehydrogenase deficiency", 0.8435061416819137], ["P12694", "BCKDHA", "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 24, 91.56, 0, 0, null, null, 0, 0, null, 1, "maple syrup urine disease type 1A", 0.8431584865455812], ["P36871", "PGM1", "Phosphoglucomutase-1", "Tier 1.5", 0.753, 1, "B_cargo", 16, 97.12, 0, 0, null, null, 0, 0, null, 1, "PGM1-congenital disorder of glycosylation", 0.843931261346685], ["O95571", "ETHE1", "Persulfide dioxygenase ETHE1, mitochondrial", "Tier 1.5", 0.752, 1, "B_cargo", 1, 92.88, 0, 0, null, null, 0, 0, null, 1, "ethylmalonic encephalopathy", 0.8389957647020829], ["P07686", "HEXB", "Beta-hexosaminidase subunit beta", "Tier 1", 0.751, 1, "B_cargo", 8, 92.81, 0, 0, null, null, 0, 0, null, 1, "Sandhoff disease", 0.8358490853539441], ["Q9BX63", "BRIP1", "Fanconi anemia group J protein", "Tier 1", 0.751, 1, "B_cargo", 3, 63.88, 0, 0, null, null, 0, 0, null, 1, "Fanconi anemia complementation group J", 0.8380329286110476], ["Q8TB36", "GDAP1", "Ganglioside-induced differentiation-associated protein 1", "Tier 1", 0.75, 1, "B_cargo", 8, 87.31, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive Charcot-Marie-Tooth disease with hoarseness", 0.8335233921018209], ["P54886", "ALDH18A1", "Delta-1-pyrroline-5-carboxylate synthase", "Tier 1.5", 0.75, 1, "B_cargo", 1, 84.19, 0, 0, null, null, 0, 0, null, 1, "ALDH18A1-related de Barsy syndrome", 0.8337004817329543], ["P06132", "UROD", "Uroporphyrinogen decarboxylase", "Tier 1", 0.749, 1, "B_cargo", 19, 96.75, 0, 0, null, null, 0, 0, null, 1, "Familial porphyria cutanea tarda", 0.8298171209078576], ["P51659", "HSD17B4", "Peroxisomal multifunctional enzyme type 2", "Tier 1", 0.749, 1, "B_cargo", 7, 89.0, 0, 0, null, null, 0, 0, null, 1, "d-bifunctional protein deficiency", 0.830341815259975], ["Q9UBK8", "MTRR", "Methionine synthase reductase", "Tier 1", 0.749, 1, "B_cargo", 2, 85.31, 0, 0, null, null, 0, 0, null, 1, "methylcobalamin deficiency type cblE", 0.8288259674381309], ["O14936", "CASK", "Peripheral plasma membrane protein CASK", "Tier 1", 0.749, 1, "B_cargo", 22, 78.94, 0, 0, null, null, 0, 0, null, 1, "X-linked intellectual disability, Najm type", 0.8302355593197244], ["Q9H0F7", "ARL6", "ADP-ribosylation factor-like protein 6", "Tier 1.5", 0.749, 1, "B_cargo", 1, 94.69, 0, 0, null, null, 0, 0, null, 1, "Bardet-Biedl syndrome", 0.831055560105815], ["P04075", "ALDOA", "Fructose-bisphosphate aldolase A", "Tier 1", 0.748, 1, "B_cargo", 8, 96.44, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to aldolase A deficiency", 0.826807229393595], ["P32322", "PYCR1", "Pyrroline-5-carboxylate reductase 1, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 47, 89.81, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive cutis laxa type 2B", 0.826514119676127], ["P02538", "KRT6A", "Keratin, type II cytoskeletal 6A", "Tier 1.5", 0.748, 1, "B_cargo", 1, 66.31, 0, 0, null, null, 0, 0, null, 1, "pachyonychia congenita", 0.8265917804295808], ["P55809", "OXCT1", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Tier 1.5", 0.748, 1, "B_cargo", 1, 91.94, 0, 0, null, null, 0, 0, null, 1, "succinyl-CoA:3-ketoacid CoA transferase deficiency", 0.8271377770408165], ["Q8IWV7", "UBR1", "E3 ubiquitin-protein ligase UBR1", "Tier 1.5", 0.748, 1, "B_cargo", 5, 84.69, 0, 0, null, null, 0, 0, null, 1, "Johanson-Blizzard syndrome", 0.8277473176517505], ["P00558", "PGK1", "Phosphoglycerate kinase 1", "Tier 1", 0.747, 1, "B_cargo", 30, 96.38, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to phosphoglycerate kinase 1 deficiency", 0.8228898260165487], ["P12955", "PEPD", "Xaa-Pro dipeptidase", "Tier 1.5", 0.747, 1, "B_cargo", 21, 97.44, 0, 0, null, null, 0, 0, null, 1, "prolidase deficiency", 0.8227965856258603], ["Q15833", "STXBP2", "Syntaxin-binding protein 2", "Tier 1.5", 0.747, 1, "B_cargo", 1, 90.0, 0, 0, null, null, 0, 0, null, 1, "Familial hemophagocytic lymphohistiocytosis", 0.8239664182555839], ["O43819", "SCO2", "Cytochrome c oxidase assembly factor SCO2", "Tier 1", 0.746, 1, "B_cargo", 1, 83.75, 0, 0, null, null, 0, 0, null, 1, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.8204831517684852], ["Q14739", "LBR", "Delta(14)-sterol reductase LBR", "Tier 1.5", 0.746, 1, "B_cargo", 1, 76.62, 0, 0, null, null, 0, 0, null, 1, "Greenberg dysplasia", 0.8198252534620432], ["P08237", "PFKM", "ATP-dependent 6-phosphofructokinase, muscle type", "Tier 1.5", 0.746, 1, "B_cargo", 1, 91.69, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease VII", 0.8199812991737021], ["P09467", "FBP1", "Fructose-1,6-bisphosphatase 1", "Tier 1", 0.745, 1, "B_cargo", 51, 94.31, 0, 0, null, null, 0, 0, null, 1, "fructose-1,6-bisphosphatase deficiency", 0.8178590536523854], ["P38571", "LIPA", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Tier 1.5", 0.745, 1, "B_cargo", 1, 91.56, 0, 0, null, null, 0, 0, null, 1, "cholesteryl ester storage disease", 0.8176913717992665], ["Q14938", "NFIX", "Nuclear factor 1 X-type", "Tier 1.5", 0.745, 1, "B_cargo", 3, 61.62, 0, 0, null, null, 0, 0, null, 1, "Malan overgrowth syndrome", 0.8156080181042044], ["P02549", "SPTA1", "Spectrin alpha chain, erythrocytic 1", "Tier 1.5", 0.745, 1, "B_cargo", 3, 76.38, 0, 0, null, null, 0, 0, null, 1, "elliptocytosis 2", 0.8153311905916062], ["P50440", "GATM", "Glycine amidinotransferase, mitochondrial", "Tier 1", 0.744, 1, "B_cargo", 11, 89.62, 0, 0, null, null, 0, 0, null, 1, "AGAT deficiency", 0.8130880750586561], ["P17900", "GM2A", "Ganglioside GM2 activator", "Tier 1", 0.744, 1, "B_cargo", 8, 88.94, 0, 0, null, null, 0, 0, null, 1, "GM2-gangliosidosis, AB variant", 0.8134379375819221]], "truncated": false, "filtered_table_rows_count": 2628, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1351, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 1277, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1593, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 1035, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 2627, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 2628, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 2628, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1406, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 1222, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 2628, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1835.8693360351026, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}