{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.708, 100, 88.06, 0, 0, null, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613], ["P14555", "PLA2G2A", "Phospholipase A2, membrane associated", "Tier 1", 0.7, 17, 91.0, 0, 0, null, null, null, 0, 0, null, 0, "familial colorectal cancer", 0.3326218692162316], ["Q5Y7D3", "HLA-DQB1", null, "Tier 1", 0.7, 6, 85.31, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P08473", "MME", "Neprilysin", "Tier 1", 0.699, 16, 96.19, 0, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["O43570", "CA12", "Carbonic anhydrase 12", "Tier 1", 0.695, 40, 87.81, 0, 0, null, null, null, 0, 0, null, 0, "isolated hyperchlorhidrosis", 0.6794515382695604], ["Q96QV1", "HHIP", "Hedgehog-interacting protein", "Tier 1", 0.692, 11, 79.75, 0, 0, null, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.5195282784554633], ["P04435", "TRBV7-9", "T cell receptor beta variable 7-9", "Tier 1", 0.691, 2, 90.06, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.11454334012562349], ["Q02083", "NAAA", "N-acylethanolamine-hydrolyzing acid amidase", "Tier 1", 0.69, 2, 92.25, 0, 0, null, null, null, 0, 0, null, 0, "abscess", 0.2726858643799341], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.69, 3, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.69, 100, 46.72, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["A0A9P1NJI6", null, null, "Tier 1", 0.69, 6, null, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.687, 3, 92.44, 0, 0, null, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125], ["O95399", "UTS2", "Urotensin-2", "Tier 1", 0.685, 2, 58.44, 0, 0, null, null, null, 0, 0, null, 1, "hair color", 0.35316475479030335], ["A0A0C4DH28", "TRGV4", "T cell receptor gamma variable 4", "Tier 1", 0.681, 4, 84.06, 0, 0, null, null, null, 0, 0, null, 0, "Townes-Brocks syndrome", 0.006652437384324632], ["Q99584", "S100A13", "Protein S100-A13", "Tier 1", 0.681, 12, 80.81, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41302685279153983], ["U5YJJ6", "HLA-A", null, "Tier 1", 0.68, 3, 89.0, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q16651", "PRSS8", "Prostasin", "Tier 1", 0.68, 9, 83.75, 0, 0, null, null, null, 0, 0, null, 0, "Alzheimer disease", 0.4223067864061274], ["Q9HBI1", "PARVB", "Beta-parvin", "Tier 1", 0.68, 3, 81.75, 0, 0, null, null, null, 0, 0, null, 1, "thyroiditis", 0.28021156500366357], ["O00602", "FCN1", "Ficolin-1", "Tier 1", 0.675, 7, 84.94, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.351581018821974], ["Q9UK55", "SERPINA10", "Protein Z-dependent protease inhibitor", "Tier 1", 0.672, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "macular degeneration", 0.3247169581531489], ["P02749", "APOH", "Beta-2-glycoprotein 1", "Tier 1", 0.67, 14, 93.12, 0, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.5456247991985232], ["P06703", "S100A6", "Protein S100-A6", "Tier 1", 0.67, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.10449825238323361], ["P78552", "IL13RA1", "Interleukin-13 receptor subunit alpha-1", "Tier 1", 0.67, 4, 81.56, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48627783096767857], ["P14867", "GABRA1", "Gamma-aminobutyric acid receptor subunit alpha-1", "Tier 1", 0.667, 0, 81.69, 0, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 19", 0.7734302780200346], ["P54762", "EPHB1", "Ephrin type-B receptor 1", "Tier 1", 0.665, 8, 83.62, 0, 0, null, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5204553830376101], ["Q9UHV8", "LGALS13", "Galactoside-binding soluble lectin 13", "Tier 1", 0.66, 11, 97.5, 0, 0, null, null, null, 0, 0, null, 0, "preeclampsia", 0.11027592759014439], ["Q6IQ20", "NAPEPLD", "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "Tier 1", 0.66, 4, 87.25, 0, 0, null, null, null, 0, 0, null, 0, "reticular dystrophy of the retinal pigment epithelium", 0.3695798546847018], ["A0A0U5Q247", null, null, "Tier 1", 0.66, 3, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q7L2H7", "EIF3M", "Eukaryotic translation initiation factor 3 subunit M", "Tier 1", 0.66, 0, 55.28, 0, 0, null, null, null, 0, 0, null, 1, "Hernia", 0.2963310523049043], ["Q8IYV9", "IZUMO1", "Izumo sperm-egg fusion protein 1", "Tier 1", 0.659, 7, 81.06, 0, 0, null, null, null, 0, 0, null, 0, "cholelithiasis", 0.18873738346588434], ["P48552", "NRIP1", "Nuclear receptor-interacting protein 1", "Tier 1", 0.657, 17, 45.91, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5654759320154787], ["P05543", "SERPINA7", "Thyroxine-binding globulin", "Tier 1", 0.655, 9, 87.06, 0, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.09631257418600654], ["P20701", "ITGAL", "Integrin alpha-L", "Tier 1", 0.655, 41, 82.62, 0, 0, null, null, null, 0, 0, null, 1, "psoriasis", 0.5899795223699872], ["A8MUM7", "LGALS16", "Galectin-16", "Tier 1", 0.654, 3, 94.62, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.536067027639694]], "truncated": false, "filtered_table_rows_count": 1493, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 1493, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1492, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1493, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 830, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 663, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1493, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 676.0832569998456, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}