{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.68, 86, 86.94, 0, 0, null, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266], ["P26718", "KLRK1", "NKG2-D type II integral membrane protein", "Tier 1.5", 0.679, 22, 79.19, 0, 0, null, null, null, 1, 1, "24629635", 0, "Behcet's syndrome", 0.18614538678991077], ["Q86Z14", "KLB", "Beta-klotho", "Tier 1", 0.676, 5, 89.38, 0, 0, null, null, null, 1, 1, "40514411", 0, "congenital hypogonadotropic hypogonadism", 0.462898767992589], ["P62576", "nanA", "Sialidase A", "Tier 1", 0.67, 5, 81.19, 0, 0, null, null, null, 1, 4, "37350189,34976356,34341854,32034503", 0, null, null], ["Q9GZX9", "TWSG1", "Twisted gastrulation protein homolog 1", "Tier 1", 0.67, 6, 80.38, 0, 0, null, null, null, 1, 1, "39299474", 0, "Abruptio Placentae", 0.29495361755469174], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.668, 4, 79.81, 0, 0, null, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["O00744", "WNT10B", "Protein Wnt-10b", "Tier 1.5", 0.668, 0, 80.06, 0, 0, null, null, null, 1, 2, "32810272,18673242", 0, "Split hand-split foot malformation", 0.7755225395358214], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.665, 6, 67.38, 0, 0, null, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["O15169", "AXIN1", "Axin-1", "Tier 1", 0.664, 22, 61.09, 0, 0, null, null, null, 1, 2, "28129128", 0, "hepatocellular carcinoma", 0.7864172882686208], ["Q6PCB0", "VWA1", "von Willebrand factor A domain-containing protein 1", "Tier 1.5", 0.664, 0, 78.38, 0, 0, null, null, null, 1, 4, "41906877,41693575,38904251,38299345", 0, "neuronopathy, distal hereditary motor, autosomal recessive 7", 0.7420531156755253], ["A2RU14", "TMEM218", "Transmembrane protein 218", "Tier 1.5", 0.663, 0, 87.62, 0, 0, null, null, null, 1, 6, "41360349,34861273,31349094,29277631,26580576,26248137", 0, "Joubert syndrome 39", 0.7308441626389979], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.66, 23, 47.41, 0, 0, null, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.66, 5, 87.06, 0, 0, null, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["Q86YL7", "PDPN", "Podoplanin", "Tier 1.5", 0.66, 6, 57.97, 0, 0, null, null, null, 1, 4, "41304780,41292412,39451677", 0, "Microscopic hematuria", 0.41183796492083136], ["Q92876", "KLK6", "Kallikrein-6", "Tier 1", 0.659, 21, 91.75, 0, 0, null, null, null, 1, 2, "30114962,22505517", 0, "neuroinflammatory disorder", 0.1901077464611955], ["O15389", "SIGLEC5", "Sialic acid-binding Ig-like lectin 5", "Tier 1.5", 0.656, 3, 77.75, 0, 0, null, null, null, 1, 3, "33584010,27678199,24405684", 0, "dentures", 0.15815607474115415], ["P22894", "MMP8", "Neutrophil collagenase", "Tier 1", 0.655, 25, 90.38, 0, 0, null, null, null, 1, 4, "35821507,34183667,33534888,30197987", 0, "acne", 0.603247809982021], ["P45452", "MMP13", "Collagenase 3", "Tier 1", 0.65, 49, 88.62, 0, 0, null, null, null, 1, 4, "41754778,40893365,38471488,38750696", 0, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149], ["O15263", "DEFB4A", "Defensin beta 4A", "Tier 1.5", 0.65, 6, 78.0, 0, 0, null, null, null, 1, 2, "40362575,32067984", 0, "ulcerative colitis", 0.09865892368546408], ["P84996", "GNAS", "Protein ALEX", "Tier 1.5", 0.65, 0, 43.59, 0, 0, null, null, null, 1, 9, "39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560", 0, null, null], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.648, 8, 73.25, 0, 0, null, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["Q2I0M5", "RSPO4", "R-spondin-4", "Tier 1.5", 0.646, 0, 78.56, 0, 0, null, null, null, 1, 3, "38238732,37425696", 0, "nonsyndromic congenital nail disorder 4", 0.7604902779349189], ["Q9BQ51", "PDCD1LG2", "Programmed cell death 1 ligand 2", "Tier 1.5", 0.645, 2, 86.38, 0, 0, null, null, null, 1, 1, "38928037", 0, "melanoma", 0.42716921377769757], ["Q9UKP5", "ADAMTS6", "A disintegrin and metalloproteinase with thrombospondin motifs 6", "Tier 1.5", 0.644, 0, 77.5, 0, 0, null, null, null, 1, 1, "35700850", 0, "Abnormality of the skeletal system", 0.5444162515485208], ["P10747", "CD28", "T-cell-specific surface glycoprotein CD28", "Tier 1", 0.641, 10, 81.31, 0, 0, null, null, null, 1, 12, "40702285,40479828,36979667,36126113,32584540,32280743,32024070,26999456,26992239,26320067,23756353,10435754", 0, "HIV infection", 0.5105949023227331], ["Q04609", "FOLH1", "Glutamate carboxypeptidase 2", "Tier 1", 0.64, 88, 93.81, 0, 0, null, null, null, 1, 47, "41855944,41683470,41548790,41478044,41126016,40684732,39388218,39187748,38769597,34341883,33794195,33061374,33025277,32721116,32611993,32525981,32208602,29313393,28794625,28746182,27574424,27456457,27228412,27077564,26985893,26472453,26438155,25938427,25620467,25620167,25473281,24954476,24337602,24321253,23590171,21980237,21641946,21555850,21147500,20550178,20407731,19701187,19514954,19488725,18776550,15520166,12124337", 0, "prostate cancer", 0.5500818985644047], ["P07202", "TPO", "Thyroid peroxidase", "Tier 1.5", 0.64, 0, 83.44, 0, 0, null, null, null, 1, 1, "29881374", 0, "familial thyroid dyshormonogenesis", 0.6710562308468054], ["P31994", "FCGR2B", "Low affinity immunoglobulin gamma Fc region receptor II-b", "Tier 1.5", 0.636, 5, 78.44, 0, 0, null, null, null, 1, 1, "38928037", 0, "systemic lupus erythematosus", 0.460465747544726], ["Q16674", "MIA", "Melanoma-derived growth regulatory protein", "Tier 1.5", 0.636, 4, 86.38, 0, 0, null, null, null, 1, 15, "41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019", 0, "neurodegenerative disease", 0.36367051545295126], ["Q92563", "SPOCK2", "Testican-2", "Tier 1.5", 0.627, 0, 66.94, 0, 0, null, null, null, 1, 8, "39695715,35474272,32958645,28794177,38656806,36288905", 0, "Back pain", 0.3687304175767662], ["P34810", "CD68", "Macrosialin", "Tier 1.5", 0.627, 0, 73.19, 0, 0, null, null, null, 1, 4, "37422510,33321636,28315675,27940247", 0, "neurodegenerative disease", 0.3710186480081222], ["Q96NZ8", "WFIKKN1", "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "Tier 1.5", 0.621, 2, 78.06, 0, 0, null, null, null, 1, 1, "33591955", 0, "neurodegenerative disease", 0.3060887002952384]], "truncated": false, "filtered_table_rows_count": 454, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 211, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 1, "label": 1, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 298.03060199628817, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}