{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 1 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["Q96IY4", "CPB2", "Carboxypeptidase B2", "Tier 1", 0.709, 10, 94.12, 0, 0, null, null, null, 1, 4, "37329944,36805075,35861072,30297859", 1, "type 2 diabetes mellitus", 0.19338213943947646], ["P25311", "AZGP1", "Zinc-alpha-2-glycoprotein", "Tier 1", 0.701, 9, 92.88, 0, 0, null, null, null, 1, 1, "41325160", 1, "neoplasm", 0.10887540652591159], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.695, 40, 91.0, 0, 0, null, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["P22303", "ACHE", "Acetylcholinesterase", "Tier 1", 0.685, 78, 92.94, 0, 0, null, null, null, 1, 135, "41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840", 1, "Alzheimer disease", 0.628678841772617], ["P03950", "ANG", "Angiogenin", "Tier 1", 0.685, 56, 89.81, 0, 0, null, null, null, 1, 99, "41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572", 1, "amyotrophic lateral sclerosis", 0.7865457274017922], ["P01008", "SERPINC1", "Antithrombin-III", "Tier 1", 0.685, 27, 84.69, 0, 0, null, null, null, 1, 11, "32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984", 1, "hereditary antithrombin deficiency", 0.8494671886642873], ["Q15485", "FCN2", "Ficolin-2", "Tier 1", 0.682, 13, 85.12, 0, 0, null, null, null, 1, 2, "27490795", 1, "hypopituitarism", 0.2753784074131916], ["Q07954", "LRP1", "Prolow-density lipoprotein receptor-related protein 1", "Tier 1", 0.682, 7, 79.19, 0, 0, null, null, null, 1, 3, "41599761,38996211,25855589", 1, "developmental dysplasia of the hip", 0.6197148309275711], ["P00918", "CA2", "Carbonic anhydrase 2", "Tier 1", 0.68, 100, 97.38, 0, 0, null, null, null, 1, 109, "41955789,41543229,41513346,40854266,40783389,40744710,40660917,40411663,40380946,40321028,39978259,39928524,39716707,39536855,39515698,38946763,38693181,38462338,38409486,37997814,37726778,37148800,37103734,36792529,36410157,36140102,36107718,35490167,35344667,35211356,35194086,35022247,35006986,34619285,34607961,34440571,34399193,34362425,34166652,33832411,33479839,33410656,33230701,33080851,32991252,35516485,32700526,32493583,32331372,32304233", 1, "Osteopetrosis with renal tubular acidosis", 0.7929568656592082], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.68, 86, 86.94, 0, 0, null, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266], ["P09958", "FURIN", "Furin", "Tier 1", 0.68, 48, 84.75, 0, 0, null, null, null, 1, 4, "36291832,24808863", 1, "coronary artery disease", 0.5783535503692275], ["Q86Z14", "KLB", "Beta-klotho", "Tier 1", 0.676, 5, 89.38, 0, 0, null, null, null, 1, 1, "40514411", 0, "congenital hypogonadotropic hypogonadism", 0.462898767992589], ["P09382", "LGALS1", "Galectin-1", "Tier 1", 0.675, 41, 96.5, 0, 0, null, null, null, 1, 6, "37141264,33006019,31778957", 1, "glaucoma", 0.2854257184852107], ["P62576", "nanA", "Sialidase A", "Tier 1", 0.67, 5, 81.19, 0, 0, null, null, null, 1, 4, "37350189,34976356,34341854,32034503", 0, null, null], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.67, 14, 81.19, 0, 0, null, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["Q9GZX9", "TWSG1", "Twisted gastrulation protein homolog 1", "Tier 1", 0.67, 6, 80.38, 0, 0, null, null, null, 1, 1, "39299474", 0, "Abruptio Placentae", 0.29495361755469174], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.669, 100, 79.25, 0, 0, null, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P56817", "BACE1", "Beta-secretase 1", "Tier 1", 0.668, 100, 87.5, 0, 0, null, null, null, 1, 9, "39241336,36149663,35402070,31513457,30959405,29327496,26473367,23832586,16888322", 1, "metabolic disease", 0.42482013576989197], ["P08311", "CTSG", "Cathepsin G", "Tier 1", 0.667, 16, 91.38, 0, 0, null, null, null, 1, 6, "41316897,40501769,9062133,23598134,19325843", 1, "tuberculosis", 0.37188972877648113], ["O15169", "AXIN1", "Axin-1", "Tier 1", 0.664, 22, 61.09, 0, 0, null, null, null, 1, 2, "28129128", 0, "hepatocellular carcinoma", 0.7864172882686208], ["Q9Y251", "HPSE", "Heparanase", "Tier 1", 0.66, 58, 94.69, 0, 0, null, null, null, 1, 7, "41363219,31252265,30086306,28150826,25295847,23968994,22719856", 1, "Vitiligo", 0.3120033501413742], ["Q13093", "PLA2G7", "Platelet-activating factor acetylhydrolase", "Tier 1", 0.66, 33, 87.81, 0, 0, null, null, null, 1, 1, "35187107", 1, "Platelet-activating factor acetylhydrolase deficiency", 0.6405981442654826], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.66, 23, 47.41, 0, 0, null, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["Q92876", "KLK6", "Kallikrein-6", "Tier 1", 0.659, 21, 91.75, 0, 0, null, null, null, 1, 2, "30114962,22505517", 0, "neuroinflammatory disorder", 0.1901077464611955], ["P02461", "COL3A1", "Collagen alpha-1(III) chain", "Tier 1", 0.656, 11, 53.25, 0, 0, null, null, null, 1, 1, "28453726", 1, "Ehlers-Danlos syndrome, vascular type", 0.8608667500207768], ["P22894", "MMP8", "Neutrophil collagenase", "Tier 1", 0.655, 25, 90.38, 0, 0, null, null, null, 1, 4, "35821507,34183667,33534888,30197987", 0, "acne", 0.603247809982021], ["P15907", "ST6GAL1", "Beta-galactoside alpha-2,6-sialyltransferase 1", "Tier 1", 0.655, 4, 88.12, 0, 0, null, null, null, 1, 1, "41889102", 1, "COVID-19", 0.5471103766359176], ["P08709", "F7", "Coagulation factor VII", "Tier 1", 0.655, 100, 82.12, 0, 0, null, null, null, 1, 4, "41980687,32224381,28496951,11127866", 1, "factor VII deficiency", 0.8542078994169972], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.653, 11, 82.62, 0, 0, null, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["P62937", "PPIA", "Peptidyl-prolyl cis-trans isomerase A", "Tier 1", 0.652, 100, 98.06, 0, 0, null, null, null, 1, 1, "30121422", 1, "HIV infection", 0.6219943433906236], ["P45452", "MMP13", "Collagenase 3", "Tier 1", 0.65, 49, 88.62, 0, 0, null, null, null, 1, 4, "41754778,40893365,38471488,38750696", 0, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149]], "truncated": false, "filtered_table_rows_count": 647, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 641, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 6, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 404, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 344.1882820043247, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}