{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, has_known_aptamer = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.71, 0, 87.69, 0, 0, null, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P19021", "PAM", "Peptidyl-glycine alpha-amidating monooxygenase", "Tier 1.5", 0.695, 0, 71.69, 0, 0, null, null, null, 1, 25, "41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210", 1, "type 2 diabetes mellitus", 0.5754371880839976], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["P10586", "PTPRF", "Receptor-type tyrosine-protein phosphatase F", "Tier 1.5", 0.69, 13, 82.0, 0, 0, null, null, null, 1, 4, "42101929,39087949,36594741", 1, "smoking initiation", 0.4641111755355386], ["O00501", "CLDN5", "Claudin-5", "Tier 1.5", 0.685, 0, 83.75, 0, 0, null, null, null, 1, 1, "18951306", 1, "genetic disorder", 0.40861362787778505], ["P14384", "CPM", "Carboxypeptidase M", "Tier 1.5", 0.68, 1, 90.31, 0, 0, null, null, null, 1, 3, "38876068,38060303,36768220", 1, "hydronephrosis", 0.3163273148871551], ["P26718", "KLRK1", "NKG2-D type II integral membrane protein", "Tier 1.5", 0.679, 22, 79.19, 0, 0, null, null, null, 1, 1, "24629635", 0, "Behcet's syndrome", 0.18614538678991077], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.673, 7, 82.69, 0, 0, null, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.671, 5, 81.12, 0, 0, null, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.668, 4, 79.81, 0, 0, null, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["O00744", "WNT10B", "Protein Wnt-10b", "Tier 1.5", 0.668, 0, 80.06, 0, 0, null, null, null, 1, 2, "32810272,18673242", 0, "Split hand-split foot malformation", 0.7755225395358214], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.665, 6, 67.38, 0, 0, null, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["Q6PCB0", "VWA1", "von Willebrand factor A domain-containing protein 1", "Tier 1.5", 0.664, 0, 78.38, 0, 0, null, null, null, 1, 4, "41906877,41693575,38904251,38299345", 0, "neuronopathy, distal hereditary motor, autosomal recessive 7", 0.7420531156755253], ["A2RU14", "TMEM218", "Transmembrane protein 218", "Tier 1.5", 0.663, 0, 87.62, 0, 0, null, null, null, 1, 6, "41360349,34861273,31349094,29277631,26580576,26248137", 0, "Joubert syndrome 39", 0.7308441626389979], ["P16870", "CPE", "Carboxypeptidase E", "Tier 1.5", 0.66, 0, 90.38, 0, 0, null, null, null, 1, 16, "39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227", 1, "BDV syndrome", 0.7029731914682913], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.66, 5, 87.06, 0, 0, null, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["Q86YL7", "PDPN", "Podoplanin", "Tier 1.5", 0.66, 6, 57.97, 0, 0, null, null, null, 1, 4, "41304780,41292412,39451677", 0, "Microscopic hematuria", 0.41183796492083136], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.66, 4, 77.25, 0, 0, null, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["Q13433", "SLC39A6", "Zinc transporter ZIP6", "Tier 1.5", 0.66, 0, 60.44, 0, 0, null, null, null, 1, 1, "40132409", 1, "breast cancer", 0.11188167100061543], ["O15389", "SIGLEC5", "Sialic acid-binding Ig-like lectin 5", "Tier 1.5", 0.656, 3, 77.75, 0, 0, null, null, null, 1, 3, "33584010,27678199,24405684", 0, "dentures", 0.15815607474115415], ["Q9Y625", "GPC6", "Glypican-6", "Tier 1.5", 0.655, 0, 82.0, 0, 0, null, null, null, 1, 1, "40093223", 1, "autosomal recessive omodysplasia", 0.7503216726357611], ["P02766", "TTR", "Transthyretin", "Tier 1.5", 0.655, 0, 88.0, 0, 0, null, null, null, 1, 11, "39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452", 1, "amyloidosis, hereditary systemic 1", 0.846421986844374], ["Q9H0R3", "TMEM222", "Transmembrane protein 222", "Tier 1.5", 0.654, 0, 84.81, 0, 0, null, null, null, 1, 3, "41643149,36174865,25998051", 1, "neurodevelopmental disorder with motor and speech delay and behavioral abnormalities", 0.6449281600938256], ["O15263", "DEFB4A", "Defensin beta 4A", "Tier 1.5", 0.65, 6, 78.0, 0, 0, null, null, null, 1, 2, "40362575,32067984", 0, "ulcerative colitis", 0.09865892368546408], ["P84996", "GNAS", "Protein ALEX", "Tier 1.5", 0.65, 0, 43.59, 0, 0, null, null, null, 1, 9, "39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560", 0, null, null], ["P32942", "ICAM3", "Intercellular adhesion molecule 3", "Tier 1.5", 0.648, 1, 87.12, 0, 0, null, null, null, 1, 3, "40650261,34730968,17660953", 1, "lymphatic system disease", 0.28331776251399693], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.648, 8, 73.25, 0, 0, null, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["Q2I0M5", "RSPO4", "R-spondin-4", "Tier 1.5", 0.646, 0, 78.56, 0, 0, null, null, null, 1, 3, "38238732,37425696", 0, "nonsyndromic congenital nail disorder 4", 0.7604902779349189], ["Q9BQ51", "PDCD1LG2", "Programmed cell death 1 ligand 2", "Tier 1.5", 0.645, 2, 86.38, 0, 0, null, null, null, 1, 1, "38928037", 0, "melanoma", 0.42716921377769757], ["Q9UKP5", "ADAMTS6", "A disintegrin and metalloproteinase with thrombospondin motifs 6", "Tier 1.5", 0.644, 0, 77.5, 0, 0, null, null, null, 1, 1, "35700850", 0, "Abnormality of the skeletal system", 0.5444162515485208], ["Q14242", "SELPLG", "P-selectin glycoprotein ligand 1", "Tier 1.5", 0.64, 1, 50.38, 0, 0, null, null, null, 1, 1, "25979951", 1, "glaucoma", 0.40058604767334977], ["P07202", "TPO", "Thyroid peroxidase", "Tier 1.5", 0.64, 0, 83.44, 0, 0, null, null, null, 1, 1, "29881374", 0, "familial thyroid dyshormonogenesis", 0.6710562308468054], ["P31994", "FCGR2B", "Low affinity immunoglobulin gamma Fc region receptor II-b", "Tier 1.5", 0.636, 5, 78.44, 0, 0, null, null, null, 1, 1, "38928037", 0, "systemic lupus erythematosus", 0.460465747544726], ["Q16674", "MIA", "Melanoma-derived growth regulatory protein", "Tier 1.5", 0.636, 4, 86.38, 0, 0, null, null, null, 1, 15, "41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019", 0, "neurodegenerative disease", 0.36367051545295126], ["P01732", "CD8A", "T-cell surface glycoprotein CD8 alpha chain", "Tier 1.5", 0.635, 8, 78.19, 0, 0, null, null, null, 1, 2, "38487531,36979667", 1, "progressive supranuclear palsy", 0.2036023725502463], ["Q92563", "SPOCK2", "Testican-2", "Tier 1.5", 0.627, 0, 66.94, 0, 0, null, null, null, 1, 8, "39695715,35474272,32958645,28794177,38656806,36288905", 0, "Back pain", 0.3687304175767662], ["P34810", "CD68", "Macrosialin", "Tier 1.5", 0.627, 0, 73.19, 0, 0, null, null, null, 1, 4, "37422510,33321636,28315675,27940247", 0, "neurodegenerative disease", 0.3710186480081222], ["P51884", "LUM", "Lumican", "Tier 1.5", 0.625, 0, 90.38, 0, 0, null, null, null, 1, 7, "41744190,36785906,28453726,26230699,24180352,23890607", 1, "lumbar disc herniation", 0.3492311458288365], ["P49862", "KLK7", "Kallikrein-7", "Tier 1.5", 0.624, 12, 91.56, 0, 0, null, null, null, 1, 1, "30114962", 1, "neurodegenerative disease", 0.2420324965785189], ["P21926", "CD9", "CD9 antigen", "Tier 1.5", 0.623, 5, 88.56, 0, 0, null, null, null, 1, 17, "41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386", 1, "diphtheria", 0.5261379875719714], ["Q96NZ8", "WFIKKN1", "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "Tier 1.5", 0.621, 2, 78.06, 0, 0, null, null, null, 1, 1, "33591955", 0, "neurodegenerative disease", 0.3060887002952384]], "truncated": false, "filtered_table_rows_count": 397, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 396, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 211, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 186, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&has_known_aptamer=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 335.2634710026905, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}