{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0 and in_cev_map = 0 sorted by priority_score descending", "rows": [["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 83.69, 0, 0, null, null, null, 0, 0, null, 0, "inflammatory bowel disease", 0.09896486250497885], ["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "neuronal intranuclear inclusion disease", 0.4999829066911242], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 47.41, 0, 0, null, null, null, 0, 0, null, 0, "Dupuytren Contracture", 0.5880367459451578], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.779, 7, 82.0, 0, 0, null, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P01568", "IFNA21", "Interferon alpha-21", "Tier 1.5", 0.777, 0, 85.0, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3695798546847018], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["Q9BVX2", "TMEM106C", "Transmembrane protein 106C", "Tier 1.5", 0.77, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "prostate carcinoma", 0.21737104399686757], ["P29017", "CD1C", "T-cell surface glycoprotein CD1c", "Tier 1.5", 0.77, 10, 88.56, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.1106047389635713], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["A0A1B0GTW7", "CIROP", "Ciliated left-right organizer metallopeptidase", "Tier 1.5", 0.764, 0, 73.44, 0, 0, null, null, null, 0, 0, null, 0, "heterotaxy, visceral, 12, autosomal", 0.6929422132808513], ["Q9BZR8", "BCL2L14", "Apoptosis facilitator Bcl-2-like protein 14", "Tier 1.5", 0.76, 0, 62.38, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.33117514363294837], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.76, 1, 74.94, 0, 0, null, null, null, 0, 0, null, 0, "Seckel syndrome 9", 0.683878095944948], ["O15370", "SOX12", "Transcription factor SOX-12", "Tier 1.5", 0.76, 0, 63.0, 0, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.3277369133971199], ["A6NI61", "MYMK", "Protein myomaker", "Tier 1.5", 0.758, 0, 90.44, 0, 0, null, null, null, 0, 0, null, 0, "Carey-Fineman-Ziter  syndrome", 0.7790386256350393], ["Q16585", "SGCB", "Beta-sarcoglycan", "Tier 1.5", 0.75, 0, 76.44, 0, 0, null, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2E", 0.8154766151472349], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P56730", "PRSS12", "Neurotrypsin", "Tier 1.5", 0.746, 0, 77.31, 0, 0, null, null, null, 0, 0, null, 0, "intellectual disability, autosomal recessive 1", 0.6621935416695687], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["Q8N6D2", "RNF182", "E3 ubiquitin-protein ligase RNF182", "Tier 1.5", 0.74, 0, 70.25, 0, 0, null, null, null, 0, 0, null, 0, "periapical tissue disease", 0.304701328693288], ["Q14246", "ADGRE1", "Adhesion G protein-coupled receptor E1", "Tier 1.5", 0.74, 0, 76.69, 0, 0, null, null, null, 0, 0, null, 0, "diabetic ketoacidosis", 0.20424823130055986], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.74, 4, 51.91, 0, 0, null, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["Q00LT1", "PRCD", "Photoreceptor disk component PRCD", "Tier 1.5", 0.737, 0, 63.97, 0, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7650522818524582], ["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "Tier 1.5", 0.735, 7, 85.62, 0, 0, null, null, null, 0, 0, null, 0, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271], ["Q9ULX7", "CA14", "Carbonic anhydrase 14", "Tier 1.5", 0.734, 2, 90.69, 0, 0, null, null, null, 0, 0, null, 0, "epilepsy", 0.4397024990575866], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.733, 4, 62.66, 0, 0, null, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P53539", "FOSB", "Protein FosB", "Tier 1.5", 0.73, 12, 59.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.22246010664492422], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.728, 5, 64.62, 0, 0, null, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["Q6MZM0", "HEPHL1", "Ferroxidase HEPHL1", "Tier 1.5", 0.72, 0, 89.44, 0, 0, null, null, null, 0, 0, null, 0, "pili torti-developmental delay-neurological abnormalities syndrome", 0.40268634456935765], ["Q15399", "TLR1", "Toll-like receptor 1", "Tier 1.5", 0.72, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5956884825296496], ["Q9NWH7", "SPATA6", "Spermatogenesis-associated protein 6", "Tier 1.5", 0.72, 0, 65.19, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.4205896274474635], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["P25100", "ADRA1D", "Alpha-1D adrenergic receptor", "Tier 1.5", 0.716, 0, 64.81, 0, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.6613200073424285], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["O60882", null, null, "Tier 1.5", 0.713, 1, 83.31, 0, 0, null, null, null, 0, 0, null, 0, "Hypomaturation amelogenesis imperfecta", 0.7281006394540224], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["Q8N9I5", "FADS6", "Fatty acid desaturase 6", "Tier 1.5", 0.71, 0, 90.62, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.71, 1, 84.19, 0, 0, null, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 2982, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 2982, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 2528, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 2982, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 2982, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 647.8653540034429, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}