{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, in_cev_map = 0 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "Tier 1.5", 0.809, 1, "A_surface", 4, 80.94, 0, 0, null, null, 0, 0, null, 0, "Pseudoxanthoma elasticum", 0.864631668818611], ["P07333", "CSF1R", "Macrophage colony-stimulating factor 1 receptor", "Tier 1", 0.802, 1, "A_surface", 26, 77.81, 0, 0, null, null, 1, 1, "29277631", 0, "leukoencephalopathy, diffuse hereditary, with spheroids 1", 0.8391971566583056], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.8, 1, "A_surface", 16, 84.94, 0, 0, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 1, 84.19, 0, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["Q01974", "ROR2", "Tyrosine-protein kinase transmembrane receptor ROR2", "Tier 1", 0.794, 1, "A_surface", 6, 68.31, 0, 0, null, null, 1, 2, "41782379,18673242", 0, "autosomal recessive Robinow syndrome", 0.8145559265435566], ["Q9UM73", "ALK", "ALK tyrosine kinase receptor", "Tier 1", 0.791, 1, "A_surface", 79, 68.19, 0, 0, null, null, 1, 6, "40347134,38604287,32218299,29205808,24116381,21281497", 0, "neuroblastoma", 0.8016889264946979], ["Q12866", "MERTK", "Tyrosine-protein kinase Mer", "Tier 1", 0.79, 1, "A_surface", 42, 72.25, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7985580877708576], ["Q4KMG0", "CDON", "Cell adhesion molecule-related/down-regulated by oncogenes", "Tier 1", 0.79, 1, "A_surface", 3, 62.03, 0, 0, null, null, 1, 3, "36333824,24629635,18698484", 0, "holoprosencephaly", 0.800378039564866], ["P16871", "IL7R", "Interleukin-7 receptor subunit alpha", "Tier 1", 0.789, 1, "A_surface", 8, 67.44, 0, 0, null, null, 0, 0, null, 0, "immunodeficiency 104", 0.7983119488718231], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "Tier 1.5", 0.789, 1, "A_surface", 1, 56.72, 0, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.7961763561533409], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.789, 1, "A_surface", 7, 82.0, 0, 0, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P15509", "CSF2RA", "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "Tier 1", 0.788, 1, "A_surface", 2, 82.0, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7922592394513138], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979], ["P22223", "CDH3", "Cadherin-3", "Tier 1", 0.786, 1, "A_surface", 19, 76.75, 0, 0, null, null, 1, 1, "41304780", 0, "EEM syndrome", 0.7851776755128059], ["Q13698", "CACNA1S", "Voltage-dependent L-type calcium channel subunit alpha-1S", "Tier 1.5", 0.786, 1, "A_surface", 2, 71.81, 0, 0, null, null, 0, 0, null, 0, "hypokalemic periodic paralysis, type 1", 0.7869997029542154], ["Q96MS0", "ROBO3", "Roundabout homolog 3", "Tier 1.5", 0.784, 1, "A_surface", 3, 63.69, 0, 0, null, null, 1, 2, "32369590", 0, "horizontal gaze palsy with progressive scoliosis", 0.7813306356858872], ["Q9H251", "CDH23", "Cadherin-23", "Tier 1", 0.781, 1, "A_surface", 6, 76.75, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1", 0.7713456285400272], ["Q8TDI8", "TMC1", "Transmembrane channel-like protein 1", "Tier 1.5", 0.781, 1, "A_surface", 1, 76.88, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive nonsyndromic hearing loss 7", 0.7694318181814068], ["P21579", "SYT1", "Synaptotagmin-1", "Tier 1", 0.779, 1, "A_surface", 24, 81.81, 0, 0, null, null, 0, 0, null, 0, "infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome", 0.7640586502824556], ["Q9NUN7", "ACER3", "Alkaline ceramidase 3", "Tier 1.5", 0.777, 1, "A_surface", 2, 93.19, 0, 0, null, null, 0, 0, null, 0, "alkaline ceramidase 3 deficiency", 0.7575827142824458], ["P26678", "PLN", "Phospholamban", "Tier 1", 0.775, 1, "A_surface", 7, 81.88, 0, 0, null, null, 1, 9, "39536855,32382487,30777430,25240642,21848510,19158349", 0, "hypertrophic cardiomyopathy", 0.750557685745381], ["Q9HBE5", "IL21R", "Interleukin-21 receptor", "Tier 1", 0.775, 1, "A_surface", 6, 64.12, 0, 0, null, null, 1, 2, "30800133,29244152", 0, "Cryptosporidiosis - chronic cholangitis - liver disease", 0.7501392499286187], ["Q9Y6Q6", "TNFRSF11A", "Tumor necrosis factor receptor superfamily member 11A", "Tier 1", 0.775, 1, "A_surface", 1, 58.91, 0, 0, null, null, 1, 1, "15562003", 0, "Osteopetrosis - hypogammaglobulinemia", 0.7487328542164448], ["P40126", "DCT", "L-dopachrome tautomerase", "Tier 1.5", 0.774, 1, "A_surface", 1, 89.12, 0, 0, null, null, 1, 1, "27245069", 0, "oculocutaneous albinism type 8", 0.7468868816172217], ["Q9Y6J6", "KCNE2", "Potassium voltage-gated channel subfamily E member 2", "Tier 1.5", 0.772, 1, "A_surface", 1, 78.25, 0, 0, null, null, 0, 0, null, 0, "Romano-Ward syndrome", 0.739531738338193], ["Q9NR97", "TLR8", "Toll-like receptor 8", "Tier 1", 0.771, 1, "A_surface", 39, 86.12, 0, 0, null, null, 1, 4, "40085160,39956743", 0, "immunodeficiency 98 with autoinflammation, X-linked", 0.7360623201088097], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.77, 1, "A_surface", 5, 64.62, 0, 0, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["Q96E22", "NUS1", "Dehydrodolichyl diphosphate synthase complex subunit NUS1", "Tier 1", 0.769, 1, "A_surface", 9, 82.0, 0, 0, null, null, 0, 0, null, 0, "congenital disorder of glycosylation type I", 0.7309837554022756], ["P26842", "CD27", "CD27 antigen", "Tier 1", 0.763, 1, "A_surface", 5, 71.69, 0, 0, null, null, 1, 3, "39841045,30609550,26320067", 0, "lymphoproliferative syndrome 2", 0.7084378623696481], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.761, 1, "A_surface", 23, 47.41, 0, 0, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.76, 1, "A_surface", 3, 80.19, 0, 0, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.759, 1, "A_surface", 2, 79.19, 0, 0, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["O00305", "CACNB4", "Voltage-dependent L-type calcium channel subunit beta-4", "Tier 1.5", 0.757, 1, "A_surface", 1, 71.81, 0, 0, null, null, 0, 0, null, 0, "episodic ataxia type 5", 0.6883498385715039], ["Q13002", "GRIK2", "Glutamate receptor ionotropic, kainate 2", "Tier 1.5", 0.757, 1, "A_surface", 2, 83.56, 0, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal recessive 6", 0.6913183275248935], ["Q9UL01", "DSE", "Dermatan-sulfate epimerase", "Tier 1.5", 0.755, 1, "A_surface", 1, 86.56, 0, 0, null, null, 0, 0, null, 0, "Ehlers-Danlos syndrome, musculocontractural type", 0.6849286764746361], ["O43570", "CA12", "Carbonic anhydrase 12", "Tier 1", 0.754, 1, "A_surface", 40, 87.81, 0, 0, null, null, 0, 0, null, 0, "isolated hyperchlorhidrosis", 0.6794515382695604], ["Q02223", "TNFRSF17", "Tumor necrosis factor receptor superfamily member 17", "Tier 1", 0.753, 1, "A_surface", 11, 64.94, 0, 0, null, null, 0, 0, null, 0, "multiple myeloma", 0.6779550435975632], ["P32970", "CD70", "CD70 antigen", "Tier 1.5", 0.75, 1, "A_surface", 1, 83.19, 0, 0, null, null, 1, 1, "30609550", 0, "severe combined immunodeficiency due to CD70 deficiency", 0.6651491980619259], ["Q9NYG8", "KCNK4", "Potassium channel subfamily K member 4", "Tier 1", 0.749, 1, "A_surface", 12, 78.69, 0, 0, null, null, 0, 0, null, 0, "facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome", 0.6619991022563834], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.744, 1, "A_surface", 6, 67.38, 0, 0, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["Q13454", "TUSC3", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3", "Tier 1", 0.743, 1, "A_surface", 4, 84.75, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive non-syndromic intellectual disability", 0.6445043495923901], ["P48551", "IFNAR2", "Interferon alpha/beta receptor 2", "Tier 1", 0.743, 1, "A_surface", 9, 64.44, 0, 0, null, null, 1, 1, "35212764", 0, "COVID-19", 0.6417504201511338], ["Q15116", "PDCD1", "Programmed cell death protein 1", "Tier 1", 0.738, 1, "A_surface", 37, 74.12, 0, 0, null, null, 1, 27, "41479885,40811947,40758411,39562585,37424077,34156677,33904236,33896107,33319876,33155587,32574155,32429721,31727249,31434881,28912094,28288993,41907643,41125194,38158454,37944524,36484532,36015348,34861397,34386332", 0, "melanoma", 0.6260691959208758], ["Q9NR96", "TLR9", "Toll-like receptor 9", "Tier 1", 0.736, 1, "A_surface", 3, 86.75, 0, 0, null, null, 1, 30, "41617261,40657739,39841045,39830661,33896107,32143069,28594360,26003847,23046187,22174879,19325804,18495099,12828856,37161583,34730968,30526333,29450964,17665991", 0, "rheumatoid arthritis", 0.6213924969410908], ["P19235", "EPOR", "Erythropoietin receptor", "Tier 1", 0.735, 1, "A_surface", 21, 66.94, 0, 0, null, null, 1, 6, "31904170,31279934,20142506,41207063", 0, "anemia (phenotype)", 0.6151472861334055], ["Q8N126", "CADM3", "Cell adhesion molecule 3", "Tier 1.5", 0.735, 1, "A_surface", 1, 84.38, 0, 0, null, null, 1, 2, "39263947", 0, "Charcot-Marie-Tooth disease, axonal, type 2FF", 0.6157861516342734], ["P29274", "ADORA2A", "Adenosine receptor A2a", "Tier 1", 0.733, 1, "A_surface", 99, 80.38, 0, 0, null, null, 0, 0, null, 0, "migraine disorder", 0.6090172565654923], ["P40200", "CD96", "T-cell surface protein tactile", "Tier 1", 0.731, 1, "A_surface", 1, 64.94, 0, 0, null, null, 0, 0, null, 0, "C syndrome", 0.6042901819592128], ["O43613", "HCRTR1", "Orexin/Hypocretin receptor type 1", "Tier 1", 0.729, 1, "A_surface", 14, 78.81, 0, 0, null, null, 0, 0, null, 0, "insomnia", 0.5956659546129768]], "truncated": false, "filtered_table_rows_count": 432, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 198, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 305, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 127, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 432, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 84, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 432, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 432, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 432, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 593.9962449483573, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}