{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, in_cev_map = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P00439", "PAH", "Phenylalanine-4-hydroxylase", "Tier 1", 0.618, 1, "B_cargo", 20, 88.69, 0, 0, null, null, 1, 11, "39435559,35394406,35081018,34973551,33386219,32587339,31349094,26043089,24749544,23583275,16914451", 0, "phenylketonuria", 0.892702971437507], ["P40337", "VHL", "von Hippel-Lindau disease tumor suppressor", "Tier 1", 0.616, 1, "B_cargo", 100, 84.44, 0, 0, null, null, 1, 5, "39437434,36250201,34549489,23142634,17290195", 0, "von Hippel-Lindau disease", 0.8883247767048489], ["P22304", "IDS", "Iduronate 2-sulfatase", "Tier 1.5", 0.613, 1, "B_cargo", 2, 93.06, 0, 0, null, null, 1, 9, "41791433,41521476,41396069,40394224,37948569,31273548,30529550,28420169,20842131", 0, "mucopolysaccharidosis type 2", 0.8781523206667287], ["O00255", "MEN1", "Menin", "Tier 1", 0.61, 1, "B_cargo", 61, 84.44, 0, 0, null, null, 0, 0, null, 0, "multiple endocrine neoplasia type 1", 0.8653255032429027], ["P35557", "GCK", "Hexokinase-4", "Tier 1", 0.609, 1, "B_cargo", 35, 93.69, 0, 0, null, null, 0, 0, null, 0, "MODY", 0.8633086470947097], ["P21549", "AGXT", "Alanine--glyoxylate aminotransferase", "Tier 1", 0.607, 1, "B_cargo", 17, 98.31, 0, 0, null, null, 0, 0, null, 0, "primary hyperoxaluria type 1", 0.8572717660798254], ["P04629", "NTRK1", "High affinity nerve growth factor receptor", "Tier 1", 0.607, 1, "B_cargo", 65, 78.25, 0, 0, null, null, 1, 1, "38604287", 0, "hereditary sensory and autonomic neuropathy type 4", 0.8579248191890114], ["Q9BZS1", "FOXP3", "Forkhead box protein P3", "Tier 1", 0.606, 1, "B_cargo", 2, 56.72, 0, 0, null, null, 1, 8, "40448637,34457999,32892748,26999456,24460675,22323540,18698484,18319343", 0, "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome", 0.8516802661294931], ["P19544", "WT1", "Wilms tumor protein", "Tier 1", 0.606, 1, "B_cargo", 28, 50.78, 0, 0, null, null, 1, 3, "27417971,19123921,11329270", 0, "Denys-Drash syndrome", 0.8525486743466777], ["P37231", "PPARG", "Peroxisome proliferator-activated receptor gamma", "Tier 1", 0.605, 1, "B_cargo", 100, 76.12, 0, 0, null, null, 1, 3, "37203464,33671292,28206680", 0, "type 2 diabetes mellitus", 0.8486094742593474], ["P23760", "PAX3", "Paired box protein Pax-3", "Tier 1", 0.605, 1, "B_cargo", 1, 63.94, 0, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 1", 0.8500072027894306], ["P54132", "BLM", "RecQ-like DNA helicase BLM", "Tier 1", 0.605, 1, "B_cargo", 15, 60.53, 0, 0, null, null, 1, 9, "40700985,38959435,34973563,33571410,33050386,31563064,30343567,27332117,19146404", 0, "Bloom syndrome", 0.8491084997646711], ["O76039", "CDKL5", "Cyclin-dependent kinase-like 5", "Tier 1.5", 0.605, 1, "B_cargo", 3, 53.12, 0, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 2", 0.8510325653635987], ["Q9UIF7", "MUTYH", "Adenine DNA glycosylase", "Tier 1.5", 0.605, 1, "B_cargo", 3, 78.94, 0, 0, null, null, 0, 0, null, 0, "familial adenomatous polyposis 2", 0.8483469680730393], ["P40692", "MLH1", "DNA mismatch repair protein Mlh1", "Tier 1", 0.604, 1, "B_cargo", 7, 77.31, 0, 0, null, null, 0, 0, null, 0, "Lynch syndrome", 0.8472183133029993], ["Q92793", "CREBBP", "CREB-binding protein", "Tier 1", 0.603, 1, "B_cargo", 100, 52.53, 0, 0, null, null, 1, 1, "39429683", 0, "Rubinstein-Taybi syndrome due to CREBBP mutations", 0.8442311239876018], ["P58012", "FOXL2", "Forkhead box protein L2", "Tier 1.5", 0.603, 1, "B_cargo", 2, 60.12, 0, 0, null, null, 1, 1, "37933840", 0, "blepharophimosis, ptosis, and epicanthus inversus syndrome", 0.841709236718747], ["P20823", "HNF1A", "Hepatocyte nuclear factor 1-alpha", "Tier 1.5", 0.602, 1, "B_cargo", 6, 56.97, 0, 0, null, null, 1, 4, "15781225,15629461", 0, "MODY", 0.8405262466243777], ["P38935", "IGHMBP2", "DNA-binding protein SMUBP-2", "Tier 1.5", 0.602, 1, "B_cargo", 4, 77.38, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive distal spinal muscular atrophy 1", 0.8396147647161344], ["O43435", "TBX1", "T-box transcription factor TBX1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 68.19, 0, 0, null, null, 1, 1, "24797903", 0, "22q11.2 deletion syndrome", 0.8406035626999856], ["P82279", "CRB1", "Protein crumbs homolog 1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 75.06, 0, 0, null, null, 0, 0, null, 0, "Leber congenital amaurosis 8", 0.8398871782775204], ["P20807", "CAPN3", "Calpain-3", "Tier 1", 0.601, 1, "B_cargo", 5, 78.25, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2A", 0.8360959201056175], ["O60260", "PRKN", "E3 ubiquitin-protein ligase parkin", "Tier 1", 0.601, 1, "B_cargo", 21, 78.06, 0, 0, null, null, 0, 0, null, 0, "Young adult-onset Parkinsonism", 0.8361755700457273], ["Q8N159", "NAGS", "N-acetylglutamate synthase, mitochondrial", "Tier 1.5", 0.601, 1, "B_cargo", 1, 79.75, 0, 0, null, null, 0, 0, null, 0, "hyperammonemia due to N-acetylglutamate synthase deficiency", 0.8382373711482316], ["Q02127", "DHODH", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Tier 1", 0.6, 1, "B_cargo", 100, 96.12, 0, 0, null, null, 1, 1, "29626096", 0, "postaxial acrofacial dysostosis", 0.8330628404263816], ["Q7Z2E3", "APTX", "Aprataxin", "Tier 1", 0.6, 1, "B_cargo", 11, 80.75, 0, 0, null, null, 0, 0, null, 0, "ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia", 0.832110422501825], ["Q13402", "MYO7A", "Unconventional myosin-VIIa", "Tier 1", 0.6, 1, "B_cargo", 1, 77.25, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1B", 0.8326791560829035], ["P49715", "CEBPA", "CCAAT/enhancer-binding protein alpha", "Tier 1", 0.6, 1, "B_cargo", 2, 61.69, 0, 0, null, null, 1, 7, "38965606,30909853,31546149,30795863,28639199,26983359", 0, "acute myeloid leukemia", 0.8336701187896877], ["Q2TBA0", "KLHL40", "Kelch-like protein 40", "Tier 1.5", 0.6, 1, "B_cargo", 1, 89.44, 0, 0, null, null, 0, 0, null, 0, "nemaline myopathy 8", 0.8348979900805442], ["Q9BY41", "HDAC8", "Histone deacetylase 8", "Tier 1", 0.599, 1, "B_cargo", 53, 95.31, 0, 0, null, null, 0, 0, null, 0, "Cornelia de Lange syndrome", 0.8312421317616957], ["O14832", "PHYH", "Phytanoyl-CoA dioxygenase, peroxisomal", "Tier 1", 0.598, 1, "B_cargo", 1, 85.44, 0, 0, null, null, 0, 0, null, 0, "Refsum disease", 0.8265474775217052], ["P22557", "ALAS2", "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "Tier 1", 0.598, 1, "B_cargo", 27, 82.19, 0, 0, null, null, 0, 0, null, 0, "X-linked sideroblastic anemia 1", 0.8266521651625864], ["P41235", "HNF4A", "Hepatocyte nuclear factor 4-alpha", "Tier 1", 0.598, 1, "B_cargo", 8, 73.88, 0, 0, null, null, 1, 1, "37016361", 0, "MODY", 0.8258786338560885], ["Q14191", "WRN", "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "Tier 1", 0.598, 1, "B_cargo", 42, 68.62, 0, 0, null, null, 1, 1, "27332117", 0, "Werner syndrome", 0.8278730962406992], ["O94761", "RECQL4", "ATP-dependent DNA helicase Q4", "Tier 1", 0.598, 1, "B_cargo", 2, 67.38, 0, 0, null, null, 1, 1, "31495919", 0, "Rothmund-Thomson syndrome type 2", 0.8261878622968941], ["Q9H3D4", "TP63", "Tumor protein 63", "Tier 1", 0.598, 1, "B_cargo", 26, 63.19, 0, 0, null, null, 1, 1, "17563751", 0, "ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3", 0.8281511708882607], ["Q9UMN6", "KMT2B", "Histone-lysine N-methyltransferase 2B", "Tier 1", 0.598, 1, "B_cargo", 4, null, 0, 0, null, null, 0, 0, null, 0, "dystonia 28, childhood-onset", 0.8253090908207902], ["P31271", "HOXA13", "Homeobox protein Hox-A13", "Tier 1.5", 0.598, 1, "B_cargo", 1, 54.28, 0, 0, null, null, 0, 0, null, 0, "hand-foot-genital syndrome", 0.8270145658663097], ["Q13485", "SMAD4", "SMAD family member 4", "Tier 1.5", 0.598, 1, "B_cargo", 12, 73.38, 0, 0, null, null, 1, 10, "39602246,35356877,33124760,32456365,31876518,29632714,27843907,21266541,17132729,16775010", 0, "juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome", 0.8277625447220475], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.598, 1, "B_cargo", 4, 62.66, 0, 0, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P11473", "VDR", "Vitamin D3 receptor", "Tier 1", 0.597, 1, "B_cargo", 52, 83.56, 0, 0, null, null, 0, 0, null, 0, "Hypocalcemic vitamin D-resistant rickets", 0.8226576498848421], ["Q8IWS0", "PHF6", "PHD finger protein 6", "Tier 1", 0.597, 1, "B_cargo", 2, 73.44, 0, 0, null, null, 0, 0, null, 0, "Borjeson-Forssman-Lehmann syndrome", 0.8219833984621376], ["P13686", "ACP5", "Tartrate-resistant acid phosphatase type 5", "Tier 1.5", 0.597, 1, "B_cargo", 2, 94.62, 0, 0, null, null, 1, 2, "30537181", 0, "Spondyloenchondrodysplasia with immune dysregulation", 0.8234579245679164], ["Q96GM8", "TOE1", "Target of EGR1 protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 1, 77.75, 0, 0, null, null, 0, 0, null, 0, "pontocerebellar hypoplasia type 7", 0.824632140055663], ["Q9UH77", "KLHL3", "Kelch-like protein 3", "Tier 1.5", 0.597, 1, "B_cargo", 3, 90.5, 0, 0, null, null, 0, 0, null, 0, "pseudohypoaldosteronism type 2D", 0.8246213773832068], ["P28069", "POU1F1", "Pituitary-specific positive transcription factor 1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 67.75, 0, 0, null, null, 0, 0, null, 0, "pituitary hormone deficiency, combined, 1", 0.8206947239178665], ["Q99453", "PHOX2B", "Paired mesoderm homeobox protein 2B", "Tier 1.5", 0.596, 1, "B_cargo", 5, 59.78, 0, 0, null, null, 0, 0, null, 0, "central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease", 0.8208322275185037], ["Q9H334", "FOXP1", "Forkhead box protein P1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 57.94, 0, 0, null, null, 0, 0, null, 0, "intellectual disability-severe speech delay-mild dysmorphism syndrome", 0.8203183311387787], ["Q7Z4S6", "KIF21A", "Kinesin-like protein KIF21A", "Tier 1", 0.595, 1, "B_cargo", 5, 70.56, 0, 0, null, null, 0, 0, null, 0, "congenital fibrosis of the extraocular muscles", 0.8179974657616618], ["P23769", "GATA2", "Endothelial transcription factor GATA-2", "Tier 1", 0.595, 1, "B_cargo", 2, 56.38, 0, 0, null, null, 0, 0, null, 0, "monocytopenia with susceptibility to infections", 0.8174326010603342]], "truncated": false, "filtered_table_rows_count": 1649, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 840, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 809, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": 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{"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1406, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1649, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1649, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1649, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1041.5736297145486, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}