{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, in_cev_map = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["Q5Y7D3", "HLA-DQB1", null, "Tier 1", 0.7, 6, 85.31, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P14555", "PLA2G2A", "Phospholipase A2, membrane associated", "Tier 1", 0.7, 17, 91.0, 0, 0, null, null, null, 0, 0, null, 0, "familial colorectal cancer", 0.3326218692162316], ["O43570", "CA12", "Carbonic anhydrase 12", "Tier 1", 0.695, 40, 87.81, 0, 0, null, null, null, 0, 0, null, 0, "isolated hyperchlorhidrosis", 0.6794515382695604], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q96QV1", "HHIP", "Hedgehog-interacting protein", "Tier 1", 0.692, 11, 79.75, 0, 0, null, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.5195282784554633], ["P04435", "TRBV7-9", "T cell receptor beta variable 7-9", "Tier 1", 0.691, 2, 90.06, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.11454334012562349], ["A0A9P1NJI6", null, null, "Tier 1", 0.69, 6, null, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.69, 100, 46.72, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["Q02083", "NAAA", "N-acylethanolamine-hydrolyzing acid amidase", "Tier 1", 0.69, 2, 92.25, 0, 0, null, null, null, 0, 0, null, 0, "abscess", 0.2726858643799341], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.687, 3, 92.44, 0, 0, null, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125], ["A0A0C4DH28", "TRGV4", "T cell receptor gamma variable 4", "Tier 1", 0.681, 4, 84.06, 0, 0, null, null, null, 0, 0, null, 0, "Townes-Brocks syndrome", 0.006652437384324632], ["Q16651", "PRSS8", "Prostasin", "Tier 1", 0.68, 9, 83.75, 0, 0, null, null, null, 0, 0, null, 0, "Alzheimer disease", 0.4223067864061274], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.68, 86, 86.94, 0, 0, null, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266], ["U5YJJ6", "HLA-A", null, "Tier 1", 0.68, 3, 89.0, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q86Z14", "KLB", "Beta-klotho", "Tier 1", 0.676, 5, 89.38, 0, 0, null, null, null, 1, 1, "40514411", 0, "congenital hypogonadotropic hypogonadism", 0.462898767992589], ["Q9GZX9", "TWSG1", "Twisted gastrulation protein homolog 1", "Tier 1", 0.67, 6, 80.38, 0, 0, null, null, null, 1, 1, "39299474", 0, "Abruptio Placentae", 0.29495361755469174], ["P62576", "nanA", "Sialidase A", "Tier 1", 0.67, 5, 81.19, 0, 0, null, null, null, 1, 4, "37350189,34976356,34341854,32034503", 0, null, null], ["P14867", "GABRA1", "Gamma-aminobutyric acid receptor subunit alpha-1", "Tier 1", 0.667, 0, 81.69, 0, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 19", 0.7734302780200346], ["O15169", "AXIN1", "Axin-1", "Tier 1", 0.664, 22, 61.09, 0, 0, null, null, null, 1, 2, "28129128", 0, "hepatocellular carcinoma", 0.7864172882686208], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.66, 23, 47.41, 0, 0, null, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["A0A0U5Q247", null, null, "Tier 1", 0.66, 3, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q6IQ20", "NAPEPLD", "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "Tier 1", 0.66, 4, 87.25, 0, 0, null, null, null, 0, 0, null, 0, "reticular dystrophy of the retinal pigment epithelium", 0.3695798546847018], ["Q9UHV8", "LGALS13", "Galactoside-binding soluble lectin 13", "Tier 1", 0.66, 11, 97.5, 0, 0, null, null, null, 0, 0, null, 0, "preeclampsia", 0.11027592759014439], ["Q8IYV9", "IZUMO1", "Izumo sperm-egg fusion protein 1", "Tier 1", 0.659, 7, 81.06, 0, 0, null, null, null, 0, 0, null, 0, "cholelithiasis", 0.18873738346588434], ["Q92876", "KLK6", "Kallikrein-6", "Tier 1", 0.659, 21, 91.75, 0, 0, null, null, null, 1, 2, "30114962,22505517", 0, "neuroinflammatory disorder", 0.1901077464611955], ["P48552", "NRIP1", "Nuclear receptor-interacting protein 1", "Tier 1", 0.657, 17, 45.91, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5654759320154787], ["P22894", "MMP8", "Neutrophil collagenase", "Tier 1", 0.655, 25, 90.38, 0, 0, null, null, null, 1, 4, "35821507,34183667,33534888,30197987", 0, "acne", 0.603247809982021], ["A8MUM7", "LGALS16", "Galectin-16", "Tier 1", 0.654, 3, 94.62, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.536067027639694], ["Q9NZK5", "ADA2", "Adenosine deaminase 2", "Tier 1", 0.653, 2, 95.81, 0, 0, null, null, null, 0, 0, null, 0, "deficiency of adenosine deaminase 2", 0.8291292532404531], ["A0A592", "TCRBV6S1A1N1", null, "Tier 1", 0.65, 1, 88.31, 0, 0, null, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 906, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 663, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 906, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 606.3776719965972, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}