{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, in_cev_map = 0 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 83.69, 0, 0, null, null, null, 0, 0, null, 0, "inflammatory bowel disease", 0.09896486250497885], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "neuronal intranuclear inclusion disease", 0.4999829066911242], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 47.41, 0, 0, null, null, null, 0, 0, null, 0, "Dupuytren Contracture", 0.5880367459451578], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.779, 7, 82.0, 0, 0, null, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P01568", "IFNA21", "Interferon alpha-21", "Tier 1.5", 0.777, 0, 85.0, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3695798546847018], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["Q9BVX2", "TMEM106C", "Transmembrane protein 106C", "Tier 1.5", 0.77, 0, 80.81, 0, 0, null, null, null, 0, 0, null, 0, "prostate carcinoma", 0.21737104399686757], ["P29017", "CD1C", "T-cell surface glycoprotein CD1c", "Tier 1.5", 0.77, 10, 88.56, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.1106047389635713], ["A0A1B0GTW7", "CIROP", "Ciliated left-right organizer metallopeptidase", "Tier 1.5", 0.764, 0, 73.44, 0, 0, null, null, null, 0, 0, null, 0, "heterotaxy, visceral, 12, autosomal", 0.6929422132808513], ["Q9BZR8", "BCL2L14", "Apoptosis facilitator Bcl-2-like protein 14", "Tier 1.5", 0.76, 0, 62.38, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.33117514363294837], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.76, 1, 74.94, 0, 0, null, null, null, 0, 0, null, 0, "Seckel syndrome 9", 0.683878095944948], ["O15370", "SOX12", "Transcription factor SOX-12", "Tier 1.5", 0.76, 0, 63.0, 0, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.3277369133971199], ["A6NI61", "MYMK", "Protein myomaker", "Tier 1.5", 0.758, 0, 90.44, 0, 0, null, null, null, 0, 0, null, 0, "Carey-Fineman-Ziter  syndrome", 0.7790386256350393], ["Q16585", "SGCB", "Beta-sarcoglycan", "Tier 1.5", 0.75, 0, 76.44, 0, 0, null, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2E", 0.8154766151472349], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P56730", "PRSS12", "Neurotrypsin", "Tier 1.5", 0.746, 0, 77.31, 0, 0, null, null, null, 0, 0, null, 0, "intellectual disability, autosomal recessive 1", 0.6621935416695687], ["Q8N6D2", "RNF182", "E3 ubiquitin-protein ligase RNF182", "Tier 1.5", 0.74, 0, 70.25, 0, 0, null, null, null, 0, 0, null, 0, "periapical tissue disease", 0.304701328693288], ["Q14246", "ADGRE1", "Adhesion G protein-coupled receptor E1", "Tier 1.5", 0.74, 0, 76.69, 0, 0, null, null, null, 0, 0, null, 0, "diabetic ketoacidosis", 0.20424823130055986], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.74, 4, 51.91, 0, 0, null, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["Q00LT1", "PRCD", "Photoreceptor disk component PRCD", "Tier 1.5", 0.737, 0, 63.97, 0, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7650522818524582], ["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "Tier 1.5", 0.735, 7, 85.62, 0, 0, null, null, null, 0, 0, null, 0, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271], ["Q9ULX7", "CA14", "Carbonic anhydrase 14", "Tier 1.5", 0.734, 2, 90.69, 0, 0, null, null, null, 0, 0, null, 0, "epilepsy", 0.4397024990575866], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.733, 4, 62.66, 0, 0, null, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P53539", "FOSB", "Protein FosB", "Tier 1.5", 0.73, 12, 59.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.22246010664492422], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.728, 5, 64.62, 0, 0, null, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["Q6MZM0", "HEPHL1", "Ferroxidase HEPHL1", "Tier 1.5", 0.72, 0, 89.44, 0, 0, null, null, null, 0, 0, null, 0, "pili torti-developmental delay-neurological abnormalities syndrome", 0.40268634456935765], ["Q15399", "TLR1", "Toll-like receptor 1", "Tier 1.5", 0.72, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5956884825296496], ["Q9NWH7", "SPATA6", "Spermatogenesis-associated protein 6", "Tier 1.5", 0.72, 0, 65.19, 0, 0, null, null, null, 0, 0, null, 0, "hypothyroidism", 0.4205896274474635], ["P25100", "ADRA1D", "Alpha-1D adrenergic receptor", "Tier 1.5", 0.716, 0, 64.81, 0, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.6613200073424285], ["O60882", null, null, "Tier 1.5", 0.713, 1, 83.31, 0, 0, null, null, null, 0, 0, null, 0, "Hypomaturation amelogenesis imperfecta", 0.7281006394540224], ["Q8N9I5", "FADS6", "Fatty acid desaturase 6", "Tier 1.5", 0.71, 0, 90.62, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.71, 1, 84.19, 0, 0, null, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["Q9H2B4", "SLC26A1", "Sulfate anion transporter 1", "Tier 1.5", 0.707, 0, 82.62, 0, 0, null, null, null, 0, 0, null, 0, "nephrolithiasis susceptibility caused by SLC26A1", 0.6690419713525324], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["O95886", "DLGAP3", "Disks large-associated protein 3", "Tier 1.5", 0.7, 0, 50.16, 0, 0, null, null, null, 0, 0, null, 0, "benign neoplasm of adrenal gland", 0.3188339358953556], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["Q96LB9", "PGLYRP3", "Peptidoglycan recognition protein 3", "Tier 1.5", 0.699, 4, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "Romano-Ward syndrome", 0.08833005834552343], ["Q01814", "ATP2B2", "Plasma membrane calcium-transporting ATPase 2", "Tier 1.5", 0.696, 0, 73.38, 0, 0, null, null, null, 0, 0, null, 0, "autosomal dominant nonsyndromic hearing loss", 0.6637167639130592], ["Q16676", "FOXD1", "Forkhead box protein D1", "Tier 1.5", 0.695, 0, 56.75, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.45840779990331637], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["P49895", "DIO1", "Type I iodothyronine deiodinase", "Tier 1.5", 0.695, 0, 92.12, 0, 0, null, null, null, 0, 0, null, 0, "thyroid hormone metabolism, abnormal, 2", 0.6505024812924749], ["P28039", "AOAH", "Acyloxyacyl hydrolase", "Tier 1.5", 0.695, 2, 90.38, 0, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.4486206035972812], ["O00337", "SLC28A1", "Sodium/nucleoside cotransporter 1", "Tier 1.5", 0.695, 0, 82.25, 0, 0, null, null, null, 0, 0, null, 0, "uridine-cytidineuria", 0.5835072752618243], ["Q9UPX6", "MINAR1", "Major intrinsically disordered Notch2-binding receptor 1", "Tier 1.5", 0.69, 0, 49.62, 0, 0, null, null, null, 0, 0, null, 0, "Hypercholesterolemia", 0.32960705987096356], ["P35712", "SOX6", "Transcription factor SOX-6", "Tier 1.5", 0.69, 0, 55.25, 0, 0, null, null, null, 0, 0, null, 0, "Tolchin-Le Caignec syndrome", 0.7327592361597494], ["P10243", "MYBL1", "Myb-related protein A", "Tier 1.5", 0.687, 0, 57.31, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5225910891181897], ["P01570", "IFNA14", "Interferon alpha-14", "Tier 1.5", 0.687, 0, 84.62, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3695798546847018], ["O00624", "SLC17A2", "Sodium-dependent phosphate transport protein 3", "Tier 1.5", 0.687, 0, 83.12, 0, 0, null, null, null, 0, 0, null, 0, "Fuchs endothelial corneal dystrophy", 0.07320524268733301]], "truncated": false, "filtered_table_rows_count": 2076, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1865, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 211, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 2076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=0&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 673.4633640007814, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}