{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, in_cev_map = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 83.56, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.4908023126074436], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 90.5, 0, 0, null, null, null, 0, 0, null, 1, "catecholaminergic polymorphic ventricular tachycardia", 0.7718998507471558], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 92.69, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.08093942543094014], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.745, 8, 79.94, 0, 0, null, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P98196", "ATP11A", "Phospholipid-transporting ATPase IH", "Tier 1.5", 0.735, 0, 82.94, 0, 0, null, null, null, 0, 0, null, 1, "hearing loss, autosomal dominant 84", 0.5506821963658654], ["P16389", "KCNA2", "Potassium voltage-gated channel subfamily A member 2", "Tier 1.5", 0.735, 0, 77.38, 0, 0, null, null, null, 0, 0, null, 1, "genetic developmental and epileptic encephalopathy", 0.7513374591580034], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.732, 9, 88.0, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["P09603", null, null, "Tier 1.5", 0.729, 8, 57.41, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["Q9P2B2", "PTGFRN", "Prostaglandin F2 receptor negative regulator", "Tier 1.5", 0.728, 0, 84.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48052208463481294], ["P22732", "SLC2A5", "Solute carrier family 2, facilitated glucose transporter member 5", "Tier 1.5", 0.728, 0, 90.56, 0, 0, null, null, null, 0, 0, null, 1, "Prolonged QT interval", 0.3326218692162316], ["Q92636", "NSMAF", "Protein FAN", "Tier 1.5", 0.725, 0, 88.31, 0, 0, null, null, null, 0, 0, null, 1, "placental retention", 0.36802220150078147], ["P79483", "HLA-DRB3", "HLA class II histocompatibility antigen, DR beta 3 chain", "Tier 1.5", 0.71, 2, 88.38, 0, 0, null, null, null, 0, 0, null, 1, null, null], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.71, 0, 87.69, 0, 0, null, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["O95562", "SFT2D2", "Vesicle transport protein SFT2B", "Tier 1.5", 0.71, 0, 78.5, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.38598268164814226], ["P03905", "MT-ND4", "NADH-ubiquinone oxidoreductase chain 4", "Tier 1.5", 0.705, 0, 93.94, 0, 0, null, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.7517935125709835], ["P19021", "PAM", "Peptidyl-glycine alpha-amidating monooxygenase", "Tier 1.5", 0.695, 0, 71.69, 0, 0, null, null, null, 1, 25, "41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210", 1, "type 2 diabetes mellitus", 0.5754371880839976], ["P01615", "IGKV2D-28", "Immunoglobulin kappa variable 2D-28", "Tier 1.5", 0.695, 0, 91.0, 0, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q30154", "HLA-DRB5", "HLA class II histocompatibility antigen, DR beta 5 chain", "Tier 1.5", 0.694, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "seasonal allergic rhinitis", 0.19424611770933498], ["Q9Y678", "COPG1", "Coatomer subunit gamma-1", "Tier 1.5", 0.692, 1, 87.88, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4905625531390244], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.691, 4, 90.62, 0, 0, null, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["P10586", "PTPRF", "Receptor-type tyrosine-protein phosphatase F", "Tier 1.5", 0.69, 13, 82.0, 0, 0, null, null, null, 1, 4, "42101929,39087949,36594741", 1, "smoking initiation", 0.4641111755355386], ["Q8IUH8", "SPPL2C", "Signal peptide peptidase-like 2C", "Tier 1.5", 0.69, 0, 67.06, 0, 0, null, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.35379836590273994], ["Q14520", "HABP2", "Factor VII-activating protease", "Tier 1.5", 0.686, 0, 77.62, 0, 0, null, null, null, 0, 0, null, 1, "follicular thyroid carcinoma", 0.46213907606907034], ["O00501", "CLDN5", "Claudin-5", "Tier 1.5", 0.685, 0, 83.75, 0, 0, null, null, null, 1, 1, "18951306", 1, "genetic disorder", 0.40861362787778505], ["Q96MP8", "KCTD7", "BTB/POZ domain-containing protein KCTD7", "Tier 1.5", 0.685, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "progressive myoclonic epilepsy type 3", 0.8021556079083692], ["P14384", "CPM", "Carboxypeptidase M", "Tier 1.5", 0.68, 1, 90.31, 0, 0, null, null, null, 1, 3, "38876068,38060303,36768220", 1, "hydronephrosis", 0.3163273148871551], ["O94842", "TOX4", "TOX high mobility group box family member 4", "Tier 1.5", 0.68, 1, 54.72, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.43085410155338943], ["Q96DA2", "RAB39B", "Ras-related protein Rab-39B", "Tier 1.5", 0.678, 1, 88.38, 0, 0, null, null, null, 0, 0, null, 1, "early-onset parkinsonism-intellectual disability syndrome", 0.7782306319395635], ["Q9UI42", "CPA4", "Carboxypeptidase A4", "Tier 1.5", 0.674, 5, 93.69, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.19026118958920038], ["P78357", "CNTNAP1", "Contactin-associated protein 1", "Tier 1.5", 0.673, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "Hypomyelination neuropathy - arthrogryposis", 0.8286745612673082], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.673, 7, 82.69, 0, 0, null, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.673, 4, 47.25, 0, 0, null, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.671, 5, 81.12, 0, 0, null, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["Q4L180", "FILIP1L", "Filamin A-interacting protein 1-like", "Tier 1.5", 0.67, 0, 67.56, 0, 0, null, null, null, 0, 0, null, 1, "Umbilical hernia", 0.375022308318664], ["Q9NVH1", "DNAJC11", "DnaJ homolog subfamily C member 11", "Tier 1.5", 0.67, 0, 84.75, 0, 0, null, null, null, 0, 0, null, 1, "smoking initiation", 0.2238015008808092], ["Q9BXX0", "EMILIN2", "EMILIN-2", "Tier 1.5", 0.67, 0, 65.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.3471636502626859], ["Q92997", "DVL3", "Segment polarity protein dishevelled homolog DVL-3", "Tier 1.5", 0.67, 9, 58.91, 0, 0, null, null, null, 0, 0, null, 1, "autosomal dominant Robinow syndrome", 0.7284158836126389], ["Q14C86", "GAPVD1", "GTPase-activating protein and VPS9 domain-containing protein 1", "Tier 1.5", 0.67, 0, 62.19, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.46694942126454214], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.669, 3, 87.81, 0, 0, null, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P09693", "CD3G", "T-cell surface glycoprotein CD3 gamma chain", "Tier 1.5", 0.667, 0, 75.25, 0, 0, null, null, null, 0, 0, null, 1, "combined immunodeficiency due to CD3gamma deficiency", 0.7703413570266988], ["Q15907", "RAB11B", "Ras-related protein Rab-11B", "Tier 1.5", 0.666, 3, 85.56, 0, 0, null, null, null, 0, 0, null, 1, "neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter", 0.7587294723766482], ["Q13049", "TRIM32", "E3 ubiquitin-protein ligase TRIM32", "Tier 1.5", 0.665, 2, 77.88, 0, 0, null, null, null, 0, 0, null, 1, "autosomal recessive limb-girdle muscular dystrophy type 2H", 0.7844213789694698], ["P48509", null, null, "Tier 1.5", 0.662, 0, 88.25, 0, 0, null, null, null, 0, 0, null, 1, "epidermolysis bullosa simplex 7, with nephropathy and deafness", 0.7253740723597262], ["O94985", "CLSTN1", "Calsyntenin-1", "Tier 1.5", 0.662, 0, 77.25, 0, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.3229417277368247], ["Q13433", "SLC39A6", "Zinc transporter ZIP6", "Tier 1.5", 0.66, 0, 60.44, 0, 0, null, null, null, 1, 1, "40132409", 1, "breast cancer", 0.11188167100061543]], "truncated": false, "filtered_table_rows_count": 1298, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1298, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1297, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 186, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 1298, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1298, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&in_cev_map=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 602.860476996284, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}