{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0 and surface_class = \"A_assoc\" sorted by evidence_priority descending", "rows": [["P00740", "F9", "Coagulation factor IX", "Tier 1", 0.866, 1, "A_assoc", 56, 80.31, 0, 0, null, null, 1, 8, "41890362,40266188,12027891,41217381,35036063,34248840,24922332", 1, "hemophilia B", 0.8880186703890781], ["Q8NBP7", "PCSK9", "Proprotein convertase subtilisin/kexin type 9", "Tier 1", 0.858, 1, "A_assoc", 62, 85.19, 0, 0, null, null, 1, 23, "41924874,41707385,41683454,38796450,36579647,35817627,35388838,33177004,32884147,32415571,28544018,28265062,27679852,27397798,23770039", 1, "familial hypercholesterolemia", 0.8604029080346239], ["P02461", "COL3A1", "Collagen alpha-1(III) chain", "Tier 1", 0.858, 1, "A_assoc", 11, 53.25, 0, 0, null, null, 1, 1, "28453726", 1, "Ehlers-Danlos syndrome, vascular type", 0.8608667500207768], ["P17405", "SMPD1", "Sphingomyelin phosphodiesterase", "Tier 1", 0.857, 1, "A_assoc", 4, 88.0, 0, 0, null, null, 1, 1, "25027855", 1, "Niemann-Pick disease type A", 0.8567797114449874], ["P08709", "F7", "Coagulation factor VII", "Tier 1", 0.856, 1, "A_assoc", 100, 82.12, 0, 0, null, null, 1, 4, "41980687,32224381,28496951,11127866", 1, "factor VII deficiency", 0.8542078994169972], ["P01008", "SERPINC1", "Antithrombin-III", "Tier 1", 0.855, 1, "A_assoc", 27, 84.69, 0, 0, null, null, 1, 11, "32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984", 1, "hereditary antithrombin deficiency", 0.8494671886642873], ["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "Tier 1.5", 0.854, 1, "A_assoc", 4, 48.47, 0, 0, null, null, 0, 0, null, 1, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.853, 1, "A_assoc", 100, 86.88, 0, 0, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P02458", "COL2A1", "Collagen alpha-1(II) chain", "Tier 1", 0.85, 1, "A_assoc", 11, 52.12, 0, 0, null, null, 1, 1, "33109602", 1, "spondyloepiphyseal dysplasia congenita", 0.8334698564095305], ["P08246", "ELANE", "Neutrophil elastase", "Tier 1", 0.849, 1, "A_assoc", 38, 88.19, 0, 0, null, null, 1, 21, "33334063,41654945,40410820,39256809,38883770,37286041,31961667,30431231,29568464,29018540,28963578,28218835,23598134,22098163,20006085,10573123,9526554,9382799,9384527,9062133,8604313", 1, "cyclic hematopoiesis", 0.8291093803980005], ["P00450", "CP", "Ceruloplasmin", "Tier 1", 0.848, 1, "A_assoc", 4, 93.69, 0, 0, null, null, 1, 130, 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"Tier 1", 0.841, 1, "A_assoc", 60, 89.12, 0, 0, null, null, 1, 6, "41924874,39263947,31862877,28794177", 1, "Finnish type amyloidosis", 0.8048371651382773], ["P02679", "FGG", "Fibrinogen gamma chain", "Tier 1", 0.84, 1, "A_assoc", 48, 85.5, 0, 0, null, null, 1, 8, "41962371,40850274,30091854,27530235,36859809,33674695,28549218,12871549", 1, "familial dysfibrinogenemia", 0.8002311001712851], ["Q9BWP8", "COLEC11", "Collectin-11", "Tier 1", 0.839, 1, "A_assoc", 3, 78.31, 0, 0, null, null, 0, 0, null, 1, "3MC syndrome 2", 0.7977893521540559], ["P20908", "COL5A1", "Collagen alpha-1(V) chain", "Tier 1", 0.839, 1, "A_assoc", 1, 51.25, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome, classic type, 1", 0.7979601586599098], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.838, 1, "A_assoc", 40, 60.34, 0, 0, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P02675", "FGB", "Fibrinogen beta chain", "Tier 1", 0.837, 1, "A_assoc", 42, 84.06, 0, 0, null, null, 1, 1, "40850274", 1, "congenital afibrinogenemia", 0.7892438060719716], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.837, 1, "A_assoc", 3, 87.81, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P03950", "ANG", "Angiogenin", "Tier 1", 0.836, 1, "A_assoc", 56, 89.81, 0, 0, null, null, 1, 99, "41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572", 1, "amyotrophic lateral sclerosis", 0.7865457274017922], ["P08253", "MMP2", "72 kDa type IV collagenase", "Tier 1", 0.836, 1, "A_assoc", 14, 89.75, 0, 0, null, null, 1, 20, "38866788,38608631,37379799,36606583,35474272,34779093,33813091,33627152,33545845,33124760,32447200,32192327,30681205,30540162,30276134,30086306,24589243,23623988,22693611,18985031", 1, "Torg-Winchester syndrome", 0.7862502046091417], ["P35609", "ACTN2", "Alpha-actinin-2", "Tier 1", 0.836, 1, "A_assoc", 16, 84.81, 0, 0, null, null, 1, 1, "38497478", 1, "dilated cardiomyopathy 1AA", 0.7856813926513253], ["Q14623", "IHH", "Indian hedgehog protein", "Tier 1", 0.836, 1, "A_assoc", 8, 84.31, 0, 0, null, null, 1, 1, "18698484", 1, "brachydactyly type A1", 0.7871957785711762], ["P13645", "KRT10", "Keratin, type I cytoskeletal 10", "Tier 1", 0.836, 1, "A_assoc", 6, 64.31, 0, 0, null, null, 0, 0, null, 1, "epidermolytic hyperkeratosis 2A, autosomal dominant", 0.7860749239386174], ["Q12904", "AIMP1", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Tier 1", 0.834, 1, "A_assoc", 6, 81.12, 0, 0, null, null, 0, 0, null, 1, "hypomyelinating leukodystrophy 3", 0.7806847123659254], ["O43707", "ACTN4", "Alpha-actinin-4", "Tier 1", 0.833, 1, "A_assoc", 5, 84.12, 0, 0, null, null, 0, 0, null, 1, "focal segmental glomerulosclerosis 1", 0.7778533437264424], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.832, 1, "A_assoc", 40, 91.0, 0, 0, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["P35625", "TIMP3", "Metalloproteinase inhibitor 3", "Tier 1.5", 0.831, 1, "A_assoc", 1, 87.0, 0, 0, null, null, 1, 3, "42105605,36768220", 1, "Sorsby fundus dystrophy", 0.7684253675298044], ["P07988", "SFTPB", "Pulmonary surfactant-associated protein B", "Tier 1", 0.83, 1, "A_assoc", 9, 73.06, 0, 0, null, null, 1, 1, "35438610", 1, "Neonatal acute respiratory distress with surfactant metabolism deficiency", 0.767375558073721], ["P01009", "SERPINA1", "Alpha-1-antitrypsin", "Tier 1", 0.829, 1, "A_assoc", 46, 88.62, 0, 0, null, null, 1, 12, "33534888,26070325,41021277,36980195,35581077,31747245,29065688,24121966,16242704,11584020,11017916", 1, "Alpha-1-antitrypsin deficiency", 0.764279219769394], ["P08603", "CFH", "Complement factor H", "Tier 1", 0.825, 1, "A_assoc", 51, 78.31, 0, 0, null, null, 1, 4, "40001558,37566081,36630488,36004048", 1, "complement factor H deficiency", 0.7508822531277052], ["P05121", "SERPINE1", "Plasminogen activator inhibitor 1", "Tier 1", 0.82, 1, "A_assoc", 29, 88.88, 0, 0, null, null, 1, 25, "41699153,32784904,24922319,24012635,41371773,38963794,36882463,36859809,36203210,33674695,32199927,28051346,27813404,27755560,26163061,25582325,24138169,22103403,21147843,20962041,20387790,19284310", 1, "congenital plasminogen activator inhibitor type 1 deficiency", 0.7325368931195121], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.819, 1, "A_assoc", 4, 47.25, 0, 0, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["P11597", "CETP", "Cholesteryl ester transfer protein", "Tier 1", 0.817, 1, "A_assoc", 3, 91.12, 0, 0, null, null, 1, 1, "31461490", 1, "cholesterol-ester transfer protein deficiency", 0.724152309221595], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.816, 1, "A_assoc", 9, 79.62, 0, 0, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P36955", "SERPINF1", "Pigment epithelium-derived factor", "Tier 1.5", 0.811, 1, "A_assoc", 3, 90.12, 0, 0, null, null, 1, 17, "41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805", 1, "osteogenesis imperfecta", 0.701995723393119], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "Tier 1.5", 0.81, 1, "A_assoc", 10, 89.44, 0, 0, null, null, 1, 1, "40371468", 1, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865], ["P14174", "MIF", "Macrophage migration inhibitory factor", "Tier 1", 0.809, 1, "A_assoc", 100, 98.56, 0, 0, null, null, 1, 2, "38152968,32784904", 1, "rheumatoid arthritis", 0.6976629981150114], ["P02753", "RBP4", "Retinol-binding protein 4", "Tier 1", 0.806, 1, "A_assoc", 23, 90.25, 0, 0, null, null, 1, 16, "40904334,38392020,36551028,35695183,34814699,31953481,28279618,27511589,18324839", 1, "progressive retinal dystrophy due to retinol transport defect", 0.6881202726053139], ["P08519", "LPA", "Apolipoprotein(a)", "Tier 1", 0.801, 1, "A_assoc", 16, 60.06, 0, 0, null, null, 1, 8, "36579647,32065590,18702051,41925578,36756582,34111486,30834248,24008390", 1, "cardiovascular disease", 0.6699718665639547], ["P14780", "MMP9", "Matrix metalloproteinase-9", "Tier 1", 0.798, 1, "A_assoc", 29, 82.06, 0, 0, null, null, 1, 69, "42007960,41819327,41654945,41325860,41123219,40621756,40586733,40452137,40415371,40280078,39427007,39408993,39400726,39063106,38608631,38471488,38386014,38240894,37379799,36579647,34703762,34607961,34216852,34183667,34117903,33742062,33716989,35019523,33124760,32935949,32539349,32192327,31418072,30540162,30417194,30339905,30276134,30086306,30041514,30005287,29617556,27819142,26901393,26514999,24561613,23043415,34974872,32784904", 1, "metaphyseal anadysplasia", 0.6602426382399271], ["P00749", "PLAU", "Urokinase-type plasminogen activator", "Tier 1", 0.797, 1, "A_assoc", 100, 82.12, 0, 0, null, null, 1, 15, "41335958,36358641,36156780,35563278,35197258,33918821,27755560,26926041,25793507,25620243,24922319,23038812,20962041,20387790,15560078", 1, "Quebec platelet disorder", 0.6566580092553626], ["Q13093", "PLA2G7", "Platelet-activating factor acetylhydrolase", "Tier 1", 0.792, 1, "A_assoc", 33, 87.81, 0, 0, null, null, 1, 1, "35187107", 1, "Platelet-activating factor acetylhydrolase deficiency", 0.6405981442654826], ["P09038", "FGF2", "Fibroblast growth factor 2", "Tier 1", 0.788, 1, "A_assoc", 25, 70.25, 0, 0, null, null, 1, 53, "41873087,41800529,40626724,40514411,39249203,38569854,38036609,37704353,35415885,34228298,34203430,33952673,33536494,31454678,30965238,30005872,29050945,27506449,24832383,24611155,21546514,15947805,15037076,12871718,10989176,9916931,9873529,8743324,7547864,7504300", 1, "cancer", 0.6250165466551852], ["P62937", "PPIA", "Peptidyl-prolyl cis-trans isomerase A", "Tier 1", 0.787, 1, "A_assoc", 100, 98.06, 0, 0, null, null, 1, 1, "30121422", 1, "HIV infection", 0.6219943433906236], ["Q13009", "TIAM1", "Rho guanine nucleotide exchange factor TIAM1", "Tier 1", 0.787, 1, "A_assoc", 10, 58.94, 0, 0, null, null, 1, 1, "23757206", 1, "neurodevelopmental disorder with language delay and seizures", 0.6239819350488075], ["P61626", "LYZ", "Lysozyme C", "Tier 1", 0.786, 1, "A_assoc", 100, 94.06, 0, 0, null, null, 1, 10, "40414677,38754187,37975892,34731261,34384745,27750421,32261784,24980600,23486781,32974084", 1, "Familial renal amyloidosis", 0.6187831136072062], ["P24821", "TNC", "Tenascin", "Tier 1", 0.786, 1, "A_assoc", 21, 74.88, 0, 0, null, null, 1, 49, "40903908,39861681,38642843,38081519,32593416,28084479,25423301,23280617,22595970,21902632,21071077,19707307,11590140,41775779,38377941,37222166,31728288,31301870,29876225,27604884,26316749,25924917,25871725,25698784,24432373,24275961,23764997,22938903,22241292,19377996,20641927,21825780,17172400,16820689,16595502,16595486,15509871,14676325", 1, "autosomal dominant nonsyndromic hearing loss", 0.6185860577919765], ["Q9Y6C2", "EMILIN1", "EMILIN-1", "Tier 1.5", 0.786, 1, "A_assoc", 2, 62.91, 0, 0, null, null, 0, 0, null, 1, "arterial tortuosity-bone fragility syndrome", 0.6185329512431467]], "truncated": false, "filtered_table_rows_count": 415, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_assoc"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 143, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 181, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 415, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 225, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 190, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 415, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 177, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 415, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 472.1013568341732, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}