{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, surface_class = \"A_assoc\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "Tier 1.5", 0.854, 1, "A_assoc", 4, 48.47, 0, 0, null, null, 0, 0, null, 1, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.837, 1, "A_assoc", 3, 87.81, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P35625", "TIMP3", "Metalloproteinase inhibitor 3", "Tier 1.5", 0.831, 1, "A_assoc", 1, 87.0, 0, 0, null, null, 1, 3, "42105605,36768220", 1, "Sorsby fundus dystrophy", 0.7684253675298044], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.819, 1, "A_assoc", 4, 47.25, 0, 0, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["P36955", "SERPINF1", "Pigment epithelium-derived factor", "Tier 1.5", 0.811, 1, "A_assoc", 3, 90.12, 0, 0, null, null, 1, 17, "41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805", 1, "osteogenesis imperfecta", 0.701995723393119], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "Tier 1.5", 0.81, 1, "A_assoc", 10, 89.44, 0, 0, null, null, 1, 1, "40371468", 1, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865], ["Q9Y6C2", "EMILIN1", "EMILIN-1", "Tier 1.5", 0.786, 1, "A_assoc", 2, 62.91, 0, 0, null, null, 0, 0, null, 1, "arterial tortuosity-bone fragility syndrome", 0.6185329512431467], ["P49767", "VEGFC", "Vascular endothelial growth factor C", "Tier 1.5", 0.785, 1, "A_assoc", 4, 73.19, 0, 0, null, null, 0, 0, null, 1, "Milroy disease", 0.6170524106764851], ["Q16270", "IGFBP7", "Insulin-like growth factor-binding protein 7", "Tier 1.5", 0.785, 1, "A_assoc", 1, 84.44, 0, 0, null, null, 1, 4, "41192243,27679852,41280530", 1, "familial retinal arterial macroaneurysm", 0.6182241349863704], ["P10451", "SPP1", "Osteopontin", "Tier 1.5", 0.772, 1, "A_assoc", 3, 53.41, 0, 0, null, null, 1, 62, "41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031", 1, "osteoporosis", 0.5729473764531288], ["P10909", "CLU", "Clusterin", "Tier 1.5", 0.766, 1, "A_assoc", 2, 77.31, 0, 0, null, null, 1, 5, "42041411,37179603,36980195,35383192,26061649", 1, "Alzheimer disease", 0.5545645077431476], ["P13497", "BMP1", "Bone morphogenetic protein 1", "Tier 1.5", 0.766, 1, "A_assoc", 8, 81.44, 0, 0, null, null, 1, 1, "39939919", 1, "osteogenesis imperfecta", 0.5547577676549571], ["O00622", "CCN1", "CCN family member 1", "Tier 1.5", 0.765, 1, "A_assoc", 2, 73.12, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5505331194769112], ["Q68CZ2", "TNS3", "Tensin-3", "Tier 1.5", 0.762, 1, "A_assoc", 1, 56.81, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.539772721274482], ["P55145", "MANF", "Mesencephalic astrocyte-derived neurotrophic factor", "Tier 1.5", 0.761, 1, "A_assoc", 3, 81.69, 0, 0, null, null, 1, 1, "12698297", 1, "diabetes, deafness, developmental delay, and short stature syndrome", 0.5377386885662411], ["Q9Y3B8", "REXO2", "Oligoribonuclease, mitochondrial", "Tier 1.5", 0.754, 1, "A_assoc", 10, 88.19, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5134178677464454], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.753, 1, "A_assoc", 4, 90.62, 0, 0, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["Q13177", "PAK2", "Serine/threonine-protein kinase PAK 2", "Tier 1.5", 0.736, 1, "A_assoc", 5, 74.62, 0, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.45371318009439854], ["Q13625", "TP53BP2", "Apoptosis-stimulating of p53 protein 2", "Tier 1.5", 0.735, 1, "A_assoc", 6, 58.97, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4484066399496438], ["Q9UKU9", "ANGPTL2", "Angiopoietin-related protein 2", "Tier 1.5", 0.727, 1, "A_assoc", 1, 78.19, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.4235882639081519], ["Q96SL4", "GPX7", "Glutathione peroxidase 7", "Tier 1.5", 0.721, 1, "A_assoc", 1, 92.69, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.40349356855524837], ["Q16627", "CCL14", "C-C motif chemokine 14", "Tier 1.5", 0.711, 1, "A_assoc", 2, 85.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.37013422446672883], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.706, 1, "A_assoc", 4, 77.25, 0, 0, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["P12273", "PIP", "Prolactin-inducible protein", "Tier 1.5", 0.701, 1, "A_assoc", 1, 89.69, 0, 0, null, null, 1, 7, "41440247,36179084,35726753,35336001,28107930,26297462,21559755", 1, "neurodegenerative disease", 0.3382059336442212], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.693, 1, "A_assoc", 5, 81.12, 0, 0, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["Q8WUP2", "FBLIM1", "Filamin-binding LIM protein 1", "Tier 1.5", 0.687, 1, "A_assoc", 3, 66.44, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.28975781420803737], ["Q13253", "NOG", "Noggin", "Tier 1.5", 0.685, 1, "A_assoc", 2, 86.06, 0, 0, null, null, 1, 2, "38397086", 0, "proximal symphalangism 1A", 0.7844136456463046], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.684, 1, "A_assoc", 8, 73.25, 0, 0, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.682, 1, "A_assoc", 5, 87.06, 0, 0, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["P29120", "PCSK1", "Neuroendocrine convertase 1", "Tier 1.5", 0.682, 1, "A_assoc", 3, 82.5, 0, 0, null, null, 0, 0, null, 0, "obesity due to prohormone convertase I deficiency", 0.773875795833803], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.677, 1, "A_assoc", 4, 51.91, 0, 0, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["P55789", "GFER", "FAD-linked sulfhydryl oxidase ALR", "Tier 1.5", 0.677, 1, "A_assoc", 7, 76.88, 0, 0, null, null, 0, 0, null, 0, "congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome", 0.7556346526616893], ["Q12794", "HYAL1", "Hyaluronidase-1", "Tier 1.5", 0.672, 1, "A_assoc", 1, 94.0, 0, 0, null, null, 0, 0, null, 0, "Hyaluronidase deficiency", 0.7412407206736383], ["Q92752", "TNR", "Tenascin-R", "Tier 1.5", 0.672, 1, "A_assoc", 2, 78.5, 0, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus", 0.7403484347367364], ["O15520", "FGF10", "Fibroblast growth factor 10", "Tier 1.5", 0.67, 1, "A_assoc", 2, 80.0, 0, 0, null, null, 1, 1, "35415885", 0, "Lacrimoauriculodentodigital syndrome", 0.7344198619465704], ["O00300", "TNFRSF11B", "Tumor necrosis factor receptor superfamily member 11B", "Tier 1.5", 0.666, 1, "A_assoc", 1, 86.5, 0, 0, null, null, 1, 1, "15562003", 0, "juvenile Paget disease", 0.7184894548525037], ["P11686", "SFTPC", "Surfactant protein C", "Tier 1.5", 0.663, 1, "A_assoc", 3, 70.06, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7110128683619542], ["O43897", "TLL1", null, "Tier 1.5", 0.662, 1, "A_assoc", 1, 80.31, 0, 0, null, null, 0, 0, null, 0, "atrial heart septal defect", 0.7050140477090344], ["P19835", "CEL", "Bile salt-activated lipase", "Tier 1.5", 0.658, 1, "A_assoc", 7, 82.56, 0, 0, null, null, 1, 2, "39653009,34940276", 0, "MODY", 0.6940743944678538], ["P27352", "CBLIF", "Cobalamin binding intrinsic factor", "Tier 1.5", 0.655, 1, "A_assoc", 2, 90.5, 0, 0, null, null, 0, 0, null, 0, "hereditary intrinsic factor deficiency", 0.683930100359911], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.652, 1, "A_assoc", 1, 79.62, 0, 0, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["O75594", "PGLYRP1", "Peptidoglycan recognition protein 1", "Tier 1.5", 0.649, 1, "A_assoc", 1, 91.0, 0, 0, null, null, 1, 2, "35821507,33534888", 1, "dementia", 0.16478389504231422], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.635, 1, "A_assoc", 10, 75.06, 0, 0, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["O76093", "FGF18", "Fibroblast growth factor 18", "Tier 1.5", 0.631, 1, "A_assoc", 1, 87.56, 0, 0, null, null, 1, 1, "35415885", 0, "cancer", 0.6028027301556572], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.631, 1, "A_assoc", 1, 81.5, 0, 0, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["O95445", "APOM", "Apolipoprotein M", "Tier 1.5", 0.631, 1, "A_assoc", 3, 89.44, 0, 0, null, null, 1, 10, "38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696", 1, "type 2 diabetes mellitus", 0.10169659060091507], ["Q15818", "NPTX1", "Neuronal pentraxin-1", "Tier 1.5", 0.628, 1, "A_assoc", 1, 75.75, 0, 0, null, null, 0, 0, null, 0, "spinocerebellar ataxia 50", 0.5937598292127286], ["P07098", "LIPF", "Gastric triacylglycerol lipase", "Tier 1.5", 0.626, 1, "A_assoc", 1, 89.75, 0, 0, null, null, 0, 0, null, 0, "obesity", 0.5864662753480862], ["Q9GZX6", "IL22", "Interleukin-22", "Tier 1.5", 0.619, 1, "A_assoc", 6, 88.12, 0, 0, null, null, 1, 7, "34208021,33869115,28942363,26792955,37041650", 0, "atopic eczema", 0.5627493881195745], ["O00175", "CCL24", "C-C motif chemokine 24", "Tier 1.5", 0.613, 1, "A_assoc", 2, 82.12, 0, 0, null, null, 0, 0, null, 0, "Iron deficiency anemia", 0.5428194908352497]], "truncated": false, "filtered_table_rows_count": 234, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_assoc", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 139, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 95, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 159, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 75, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 164, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 70, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 234, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_assoc&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1567.7699707448483, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}